Automated analysis of microscopic image data of host-pathogen interaction
Principal investigator in B1.
Full professor in bioinformatics at FSU Jena
Projects: A1, A2, A3, A4 (E), A5, A6, B1, B2, B4, B5, C2, C1, C3, C4 (E), C5, C6 (E), FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, FungiNet total, INF, Z1, Z2, B3 (E), A7https://orcid.org/0000-0003-3862-6546
Spatiotemporal Modeling and Simulation of Fungal Infection Processes
Head of the subgroup Stress and Immunoproteomics of the Department of Molecular and Applied Microbiology Department at the HKI
Projects: FungiNet total, INF, A1, A2, A3, A4 (E), A5, A6, B1, B2, B3 (E), B4, B5, C1, C2, C3, C4 (E), C5, C6 (E), FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, Z1, Z2
Projects: FungiNet total, INF, A1, A2, A3, A4 (E), A5, A6, B1, B3 (E), B4, B5, C1, C2, C3, C4 (E), C5, C6 (E), Z1, Z2, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, B2https://orcid.org/0000-0001-6106-724X
I am responisble for the spatial proteomics part in Z2. We provide a proteomic platform to study spatial changes of the proteome during host-fungal pathogen interaction using MALDI-MS Imaging and Lasermicrodissection. As type of biological sample we can work with cryo and formalin fixed tissue, as well as cell cultures and lysed sample solutions.
Please get into contact with me if you are interested in MALDI-MS Imaging for your research project.
Project leader C2
Institutions: Friedrich-Schiller-University, Friedrich Schiller University Jena, Jena School for Microbial Communication, Friedrich Schiller University Jena, Institute of Microbiology, Dept. of Microbiology and Molecular Biology, Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)
Management SFB FungiNet
Rolle von CD56 in der Interaktion von Natürlichen Killerzellen mit Aspergillus fumigatus
Interaktionsanalysen von humanen Dendritischen Zellen und natürlichen Killerzellen bei der Konfrontation mit Aspergillus fumigatus
Institutions: Friedrich Schiller University Jena, Institute of Microbiology, Dept. of Microbiology and Molecular Biology, Friedrich Schiller University Jena, Jena School for Microbial Communication, Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)
Within the de.NBI project my functions in the de.NBI-SysBio node comprise content curation, requirements elicitation, and community engagement for the users of biochemical reaction kinetics database SABIO-RK as well as of the data management platform SEEK.
Bioprocess data analysis (data mining)
Transcriptomics and proteomics data analysis and modelling
Gene Regulatory Network inference (Reverse engineering)
Decision making support systems in diagnostics, therapy and biotechnology
I study the analysis of high-throughput transcriptom and genome data.
For transcritom data (RNA-Seq, microarrays), I perform preprocessing and statistics to identify differentially expressed genes, as well as their functional analysis. My main focus is the analysis of transcriptom data
from human fungal pathogens in infection related conditions (f.e. nutrient limitation) as well as during the interaction with the host (dual RNA-seq).
Experimental data is used to set up mathematical models for
Projects: Not specified
Institutions: Not specified
The following bullet points characterise my scientific interests and research:
- Metabolic physiology of fungi during host infection
- Biochemical characterisation of metabolic pathways (enzyme purification and characterisation)
- Development of infection models
- Generation of fungal reporter strains
- In vivo imaging of the infection process
- Secondary metabolites from Aspergillus terreus (gene regulation, product formation, biological activity)
Prof. Dr. Thomas Dandekar
Position Professor and Chairman
Dept. of bioinformatics,
University of Würzburg
Career 1979-1986 Studies in medicine at the Ludwig Maximilians University of Munich
1982-1986 MD, Max Planck Inst. of Psychiatry, Dept. Neuropharmacology, Martinsried
1987-1988 Post-Doc, Institute Pasteur, Paris
1988- now Scientist at the European Molecular Biology