A6

I study the analysis of high-throughput transcriptom and genome data.

For transcritom data (RNA-Seq, microarrays), I perform preprocessing and statistics to identify differentially expressed genes, as well as their functional analysis. My main focus is the analysis of transcriptom data from human fungal pathogens in infection related conditions (f.e. nutrient limitation) as well as during the interaction with the host (dual RNA-seq). Experimental data is used to set up mathematical models for ...

Name Prof. Dr. Thomas Dandekar Position Professor and Chairman Affiliation Dept. of bioinformatics, Biocenter University of Würzburg Am Hubland 97074 Würzburg Phone 0931-318-4551 dandekar@biozentrum.uni-wuerzburg.de Born 23.07.1960

Career 1979-1986 Studies in medicine at the Ludwig Maximilians University of Munich 1982-1986 MD, Max Planck Inst. of Psychiatry, Dept. Neuropharmacology, Martinsried 1987-1988 Post-Doc, Institute Pasteur, Paris 1988- now Scientist at the European Molecular Biology ...

The following bullet points characterise my scientific interests and research:

• Metabolic physiology of fungi during host infection
• Biochemical characterisation of metabolic pathways (enzyme purification and characterisation)
• Development of infection models
• Generation of fungal reporter strains
• In vivo imaging of the infection process
• Secondary metabolites from Aspergillus terreus (gene regulation, product formation, biological activity)