Maja Rey

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About Maja Rey:

Within the de.NBI project my functions in the de.NBI-SysBio node comprise content curation, requirements elicitation, and community engagement for the users of biochemical reaction kinetics database SABIO-RK as well as of the data management platform SEEK.

SEEK ID: https://funginet.hki-jena.de/people/141

Location: Germany

ORCID: Not specified

Joined: 21st Jul 2017

Expertise: Data Management, Data Curation, Biochemistry, Molecular Biology, Microbiology, Phytopathology

Tools: SABIO-RK, Seek

Their tags

Aspergillus fumigatus Aspergillus fumigatus Tor kinase biological replicate Candida albicans Candida glabrata Candida parapsilosis Candida tropicalis Caspofungin CEA CF cell death compound treatment design Cph2 cph_two_deletion cytokinesis doxycyclin ex vivo design genetic modification design growth condition design Histone deacetylation Homo sapiens hours human blood vs minimal media human_neutrophils IFNg in vitro design in vivo design INF gamma iron regulation low oxygen media Methylprednisolone Microarrays minutes mitotic exit mouse kidney or YPD Mus musculus mutation nutrient sensing organism part pathogenicity design Perforin pH phagocytosis pheromone treatment Pseudomonas aeruginosa Rca1 replicate design RNA-seq sampling time point set three deficient sexual mating Siamycin signal transduction Sorbitol vs Glu vs GlucNAc strain or line stress reponse supernatant technical replicate TEM1 time series design Transcription kinetics weak organic acid white-opaque switching YPD DMEM YPD vs YPS

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Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on ...

Projects: FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, A1, A2, A3, A4 (E), A5, B1, B2, B3 (E), B4, C1, C2, C3, C4 (E), C5, C6 (E), Z2, Z1, B5, A6, A7, A8, C7

Web page: http://www.funginet.de/home.html

Showing 5 out of a possible 18 Projects Advanced Projects list for this Person with search and filtering

INF

Integrated database for experimental data

Within the Collaborative Research Center / Transregio 124 “Pathogenic fungi and their human host: Networks of Interaction – FungiNet”, the INF project is responsible to analyse and share OMICS data. Databases help to foster the collaboration within FungiNet as an important point of the Collaborative Research Center. Therefore, we set-up two databases:

a) SEEK is a web-based platform to find, share and exchange unstructured data and knowledge, such as ...

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/project-inf.html

Organisms: Aspergillus fumigatus, Candida albicans

FungiNet total

No description specified

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/home.html

Organisms: Aspergillus fumigatus, Candida albicans

Surface proteins of Lichtheimia corymbifera as virulence determinants

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: https://www.funginet.de/project-a6.html

Organisms: Lichtheimia corymbifera

C4 (E)

Mechanisms of adhesion and modulation of human immune cells by Candida albicans

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/project-c4.html

Organisms: Candida albicans

C6 (E)

Role of secreted Candida albicans proteins in immune evasion and pathogenicity

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/project-c6.html

Organisms: Candida albicans

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HITS Heidelberger Institut für Theoretische Studien gGmbH

Country: Germany

City: Heidelberg

Web page: https://www.h-its.org

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Sample File "FungiNet_template_RNA-seq_V1.9_Ex_ID_005"

FungiNet total, A1

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Cultivation of A. fumigatus in an O2-controlled fermenter and analysed its minute-scale responses to O2 limitation. Transcriptome sequencing revealed a group of genes underlying a rapid and highly dynamic regulation.

Creators: Jörg Linde, Falk Hillmann, Olaf Kniemeyer

Submitter: Maja Rey

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Created: 5th Sep 2017 at 09:21, Last updated: 4th Jun 2018 at 12:41

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Showing 5 out of a possible 12 Publications Advanced Publications list for this Person with search and filtering

N-Acetylglucosamine-Induced Cell Death in Candida albicans and Its Implications for Adaptive Mechanisms of Nutrient Sensing in Yeasts.

FungiNet total, FungiNet C - Candida projects

Abstract (Expand)

UNLABELLED: Single-celled organisms have different strategies to sense and utilize nutrients in their ever-changing environments. The opportunistic fungal pathogen Candida albicans is a common member … of the human microbiota, especially that of the gastrointestinal (GI) tract. An important question concerns how C. albicans gained a competitive advantage over other microbes to become a successful commensal and opportunistic pathogen. Here, we report that C. albicans uses N-acetylglucosamine (GlcNAc), an abundant carbon source present in the GI tract, as a signal for nutrient availability. When placed in water, C. albicans cells normally enter the G0 phase and remain viable for weeks. However, they quickly lose viability when cultured in water containing only GlcNAc. We term this phenomenon GlcNAc-induced cell death (GICD). GlcNAc triggers the upregulation of ribosomal biogenesis genes, alterations of mitochondrial metabolism, and the accumulation of reactive oxygen species (ROS), followed by rapid cell death via both apoptotic and necrotic mechanisms. Multiple pathways, including the conserved cyclic AMP (cAMP) signaling and GlcNAc catabolic pathways, are involved in GICD. GlcNAc acts as a signaling molecule to regulate multiple cellular programs in a coordinated manner and therefore maximizes the efficiency of nutrient use. This adaptive behavior allows C. albicans' more efficient colonization of the gut. IMPORTANCE: The ability to rapidly and appropriately respond to nutrients in the environment is crucial to free-living microorganisms. To maximize the use of available nutrients, microorganisms often use a limiting nutritional component as a signal to coordinate multiple biological processes. The human fungal pathogen Candida albicans uses N-acetylglucosamine (GlcNAc) as a signal for the availability of external nutrient resources. GlcNAc induces rapid cell death in C. albicans due to the constitutive activation of oxidative metabolism and accumulation of reactive oxygen species (ROS), and multiple pathways are involved in its regulation. This study sheds light on the mechanisms of niche specialization of pathogenic fungi and raises the possibility that this cell death pathway could be an unexplored therapeutic target.

Authors: H. Du, G. Guan, X. Li, M. Gulati, L. Tao, C. Cao, A. D. Johnson, C. J. Nobile, G. Huang

Date Published: 10th Sep 2015

Publication Type: Not specified

PubMed ID: 26350972

Citation: MBio. 2015 Sep 8;6(5):e01376-15. doi: 10.1128/mBio.01376-15.

Created: 25th Sep 2017 at 10:53, Last updated: 17th Jan 2024 at 10:24

pH Regulates White-Opaque Switching and Sexual Mating in Candida albicans.

FungiNet C - Candida projects

Abstract (Expand)

As a successful commensal and pathogen of humans, Candida albicans encounters a wide range of environmental conditions. Among them, ambient pH, which changes frequently and affects many biological …

Authors: Y. Sun, C. Cao, W. Jia, L. Tao, G. Guan, G. Huang

Date Published: 6th Sep 2015

Publication Type: Not specified

PubMed ID: 26342021

Citation: Eukaryot Cell. 2015 Nov;14(11):1127-34. doi: 10.1128/EC.00123-15. Epub 2015 Sep 4.

Created: 15th Nov 2017 at 12:12, Last updated: 17th Jan 2024 at 10:24

Function and Regulation of Cph2 in Candida albicans.

FungiNet C - Candida projects

Abstract (Expand)

Candida albicans is associated with humans as both a harmless commensal organism and a pathogen. Cph2 is a transcription factor whose DNA binding domain is similar to that of mammalian sterol response …

Authors: S. Lane, P. Di Lena, K. Tormanen, P. Baldi, H. Liu

Date Published: 6th Sep 2015

Publication Type: Not specified

PubMed ID: 26342020

Citation: Eukaryot Cell. 2015 Nov;14(11):1114-26. doi: 10.1128/EC.00102-15. Epub 2015 Sep 4.

Created: 15th Nov 2017 at 12:14, Last updated: 17th Jan 2024 at 10:24

RNAseq analysis of Aspergillus fumigatus in blood reveals a just wait and see resting stage behavior.

FungiNet A - Aspergillus projects

Abstract (Expand)

BACKGROUND: Invasive aspergillosis is started after germination of Aspergillus fumigatus conidia that are inhaled by susceptible individuals. Fungal hyphae can grow in the lung through the epithelial …

Authors: H. Irmer, S. Tarazona, C. Sasse, P. Olbermann, J. Loeffler, S. Krappmann, A. Conesa, G. H. Braus

Date Published: 28th Aug 2015

Publication Type: Not specified

PubMed ID: 26311470

Citation: BMC Genomics. 2015 Aug 27;16:640. doi: 10.1186/s12864-015-1853-1.

Created: 15th Nov 2017 at 12:17, Last updated: 17th Jan 2024 at 10:24

The transcriptional stress response of Candida albicans to weak organic acids.

FungiNet total, FungiNet C - Candida projects

Abstract (Expand)

Candida albicans is the most important fungal pathogen of humans, causing severe infections, especially in nosocomial and immunocompromised settings. However, it is also the most prevalent fungus of …

Authors: F. Cottier, A. S. Tan, J. Chen, J. Lum, F. Zolezzi, M. Poidinger, N. Pavelka

Date Published: 1st Feb 2015

Publication Type: Not specified

PubMed ID: 25636313

Citation: G3 (Bethesda). 2015 Jan 29;5(4):497-505. doi: 10.1534/g3.114.015941.

Created: 18th Sep 2017 at 10:02, Last updated: 17th Jan 2024 at 10:24

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