Christine Skerka

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About Christine Skerka:

No description specified

SEEK ID: https://funginet.hki-jena.de/people/25

Location: Germany

ORCID: Not specified

Joined: 8th Jan 2013

Expertise: Host-Pathogen Interaction, Biochemistry, Immunology, innate immunity, Complement

Tools: Immunological techniques, Biochemistry and protein analysis

Their tags

Candida albicans Complement system Homo sapiens Immune evasion RNA-seq

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Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on ...

Projects: FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, A1, A2, A3, A4 (E), A5, B1, B2, B3 (E), B4, C1, C2, C3, C4 (E), C5, C6 (E), Z2, Z1, B5, A6, A7, A8, C7

Web page: http://www.funginet.de/home.html

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FungiNet total

No description specified

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/home.html

Organisms: Aspergillus fumigatus, Candida albicans

C4 (E)

Mechanisms of adhesion and modulation of human immune cells by Candida albicans

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/project-c4.html

Organisms: Candida albicans

FungiNet C - Candida projects

No description specified

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/project-area-c.html

Organisms: Candida albicans

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Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

Country: Germany

City: 07745 Jena

Web page: http://www.hki-jena.de

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Showing 5 out of a possible 11 Publications Advanced Publications list for this Person with search and filtering

Molecular analyses identifies new domains and structural differences among Streptococcus pneumoniae immune evasion proteins PspC and Hic.

FungiNet C - Candida projects, C6 (E)

Abstract (Expand)

The PspC and Hic proteins of Streptococcus pneumoniae are some of the most variable microbial immune evasion proteins identified to date. Due to structural similarities and conserved binding profiles, …

Authors: S. Du, C. Vilhena, S. King, A. Sahagun-Ruiz, S. Hammerschmidt, C. Skerka, P. F. Zipfel

Date Published: 18th Jan 2021

Publication Type: Not specified

PubMed ID: 33462258

Citation: Sci Rep. 2021 Jan 18;11(1):1701. doi: 10.1038/s41598-020-79362-3.

Created: 19th Feb 2021 at 08:51, Last updated: 17th Jan 2024 at 10:24

Immune modulation by complement receptor 3-dependent human monocyte TGF-beta1-transporting vesicles.

C4 (E)

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Abstract (Expand)

Extracellular vesicles have an important function in cellular communication. Here, we show that human and mouse monocytes release TGF-beta1-transporting vesicles in response to the pathogenic fungus …

Authors: L. D. Halder, E. A. H. Jo, M. Z. Hasan, M. Ferreira-Gomes, T. Kruger, M. Westermann, D. I. Palme, G. Rambach, N. Beyersdorf, C. Speth, I. D. Jacobsen, O. Kniemeyer, B. Jungnickel, P. F. Zipfel, C. Skerka

Date Published: 11th May 2020

Publication Type: Not specified

PubMed ID: 32393780

Citation: Nat Commun. 2020 May 11;11(1):2331. doi: 10.1038/s41467-020-16241-5.

Created: 18th Feb 2021 at 11:05, Last updated: 17th Jan 2024 at 10:24

Enolase From Aspergillus fumigatus Is a Moonlighting Protein That Binds the Human Plasma Complement Proteins Factor H, FHL-1, C4BP, and Plasminogen.

FungiNet A - Aspergillus projects, FungiNet C - Candida projects, B4

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Abstract (Expand)

The opportunistic fungal pathogen Aspergillus fumigatus can cause severe infections, particularly in immunocompromised individuals. Upon infection, A. fumigatus faces the powerful and directly acting …

Authors: P. Dasari, N. Koleci, I. A. Shopova, D. Wartenberg, N. Beyersdorf, S. Dietrich, A. Sahagun-Ruiz, M. T. Figge, C. Skerka, A. A. Brakhage, P. F. Zipfel

Date Published: 12th Dec 2019

Publication Type: Not specified

PubMed ID: 31824478

Citation: Front Immunol. 2019 Nov 22;10:2573. doi: 10.3389/fimmu.2019.02573. eCollection 2019.

Created: 16th Feb 2021 at 15:54, Last updated: 17th Jan 2024 at 10:24

Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies.

FungiNet total, FungiNet C - Candida projects, C4 (E)

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Abstract (Expand)

Persistent inflammation is a hallmark of many human diseases, including anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and atherosclerosis. Here, we describe a dominant trigger of …

Authors: S. Irmscher, S. R. Brix, S. L. H. Zipfel, L. D. Halder, S. Mutluturk, S. Wulf, E. Girdauskas, H. Reichenspurner, R. A. K. Stahl, B. Jungnickel, T. Wiech, P. F. Zipfel, C. Skerka

Date Published: 4th Jul 2019

Publication Type: Not specified

PubMed ID: 31273197

Citation: Nat Commun. 2019 Jul 4;10(1):2961. doi: 10.1038/s41467-019-10766-0.

Created: 18th Feb 2021 at 11:32, Last updated: 17th Jan 2024 at 10:24

Molecular crypsis by pathogenic fungi using human factor H. A numerical model.

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Abstract (Expand)

Molecular mimicry is the formation of specific molecules by microbial pathogens to avoid recognition and attack by the immune system of the host. Several pathogenic Ascomycota and Zygomycota show such …

Authors: S. N. Lang, S. Germerodt, C. Glock, C. Skerka, P. F. Zipfel, S. Schuster

Date Published: 20th Feb 2019

Publication Type: Not specified

PubMed ID: 30779817

Citation: PLoS One. 2019 Feb 19;14(2):e0212187. doi: 10.1371/journal.pone.0212187. eCollection 2019.

Created: 18th Feb 2021 at 09:47, Last updated: 17th Jan 2024 at 10:24

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