Sascha Schäuble

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About Sascha Schäuble:

No description specified

SEEK ID: https://funginet.hki-jena.de/people/170

Location: Germany

ORCID: https://orcid.org/0000-0003-3862-6546

Joined: 4th Jun 2020

Expertise: Systems Biology, Bioinformatics, Metabolic networks

Tools: Matlab, R, Python, Copasi, LaTeX, Systems biological modelling, Transcriptomics

Their tags

Aspergillus fumigatus Bioinformatics Candida albicans Candida auris cell wall database GSMM immune response Integrative Data Analysis metabolic modeling Metadata pathogenicity phenotypic microarray Proteomics Rhizopus arrhizus RNA-seq Systems Biology

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Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on ...

Projects: FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, A1, A2, A3, A4 (E), A5, B1, B2, B3 (E), B4, C1, C2, C3, C4 (E), C5, C6 (E), Z2, Z1, B5, A6, A7, A8, C7

Web page: http://www.funginet.de/home.html

Showing 5 out of a possible 27 Projects Advanced Projects list for this Person with search and filtering

Gene-engineered CAR T-cells and macrophages to treat Aspergillus fumigatus infection

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: https://www.funginet.de/project-a8.html

Organisms: Aspergillus fumigatus

INF

Integrated database for experimental data

Within the Collaborative Research Center / Transregio 124 “Pathogenic fungi and their human host: Networks of Interaction – FungiNet”, the INF project is responsible to analyse and share OMICS data. Databases help to foster the collaboration within FungiNet as an important point of the Collaborative Research Center. Therefore, we set-up two databases:

a) SEEK is a web-based platform to find, share and exchange unstructured data and knowledge, such as ...

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/project-inf.html

Organisms: Aspergillus fumigatus, Candida albicans

FungiNet total

No description specified

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/home.html

Organisms: Aspergillus fumigatus, Candida albicans

Role and targeting of bioactive lipid mediators in Aspergillus fumigatus innate immune cell interactions

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: https://www.funginet.de/project-a7.html

Organisms: Aspergillus fumigatus

Surface proteins of Lichtheimia corymbifera as virulence determinants

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: https://www.funginet.de/project-a6.html

Organisms: Lichtheimia corymbifera

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Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

Country: Germany

City: 07745 Jena

Web page: http://www.hki-jena.de

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Showing 5 out of a possible 43 Publications Advanced Publications list for this Person with search and filtering

Distinct transcriptional responses to fludioxonil in Aspergillus fumigatus and its DeltatcsC and Deltaskn7 mutants reveal a crucial role for Skn7 in the cell wall reorganizations triggered by this antifungal.

INF, A1

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BACKGROUND: Aspergillus fumigatus is a major fungal pathogen that causes severe problems due to its increasing resistance to many therapeutic agents. Fludioxonil is a compound that triggers a lethal …

Authors: S. Schruefer, A. Pschibul, S. S. W. Wong, T. Sae-Ong, T. Wolf, S. Schauble, G. Panagiotou, A. A. Brakhage, V. Aimanianda, O. Kniemeyer, F. Ebel

Date Published: 14th Nov 2023

Publication Type: Journal

PubMed ID: 37964194

Citation: BMC Genomics. 2023 Nov 14;24(1):684. doi: 10.1186/s12864-023-09777-5.

Created: 19th Jan 2024 at 12:02

Genome-scale metabolic modeling of Aspergillus fumigatus strains reveals growth dependencies on the lung microbiome.

INF, A1, C3

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Aspergillus fumigatus, an opportunistic human pathogen, frequently infects the lungs of people with cystic fibrosis and is one of the most common causes of infectious-disease death in immunocompromised …

Authors: M. H. Mirhakkak, X. Chen, Y. Ni, T. Heinekamp, T. Sae-Ong, L. L. Xu, O. Kurzai, A. E. Barber, A. A. Brakhage, S. Boutin, S. Schauble, G. Panagiotou

Date Published: 20th Jul 2023

Publication Type: Journal

PubMed ID: 37474497

Citation: Nat Commun. 2023 Jul 20;14(1):4369. doi: 10.1038/s41467-023-39982-5.

Created: 19th Jan 2024 at 12:08

Disruption of the Aspergillus fumigatus RNA interference machinery alters the conidial transcriptome.

INF, A1, Z2

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The RNA interference (RNAi) pathway has evolved numerous functionalities in eukaryotes, with many on display in Kingdom Fungi. RNAi can regulate gene expression, facilitate drug resistance, or even be …

Authors: A. A. Kelani, A. Bruch, F. Rivieccio, C. Visser, T. Kruger, D. Weaver, X. Pan, S. Schauble, G. Panagiotou, O. Kniemeyer, M. J. Bromley, P. Bowyer, A. E. Barber, A. A. Brakhage, M. G. Blango

Date Published: 19th Jun 2023

Publication Type: Journal

PubMed ID: 37019633

Citation: RNA. 2023 Jul;29(7):1033-1050. doi: 10.1261/rna.079350.122. Epub 2023 Apr 5.

Created: 19th Jan 2024 at 12:12

High-Throughput Profiling of Candida auris Isolates Reveals Clade-Specific Metabolic Differences.

INF, C2

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Candida auris, a multidrug-resistant human fungal pathogen that causes outbreaks of invasive infections, emerged as four distinct geographical clades. Previous studies identified genomic and proteomic … differences in nutrient utilization on comparison to Candida albicans, suggesting that certain metabolic features may contribute to C. auris emergence. Since no high-throughput clade-specific metabolic characterization has been described yet, we performed a phenotypic screening of C. auris strains from all 4 clades on 664 nutrients, 120 chemicals, and 24 stressors. We identified common and clade- or strain-specific responses, including the preferred utilization of various dipeptides as nitrogen source and the inability of the clade II isolate AR 0381 to withstand chemical stress. Further analysis of the metabolic properties of C. auris isolates showed robust growth on intermediates of the tricarboxylic acid cycle, such as citrate and succinic and malic acids. However, there was reduced or no growth on pyruvate, lactic acid, or acetate, likely due to the lack of the monocarboxylic acid transporter Jen1, which is conserved in most pathogenic Candida species. Comparison of C. auris and C. albicans transcriptomes of cells grown on alternative carbon sources and dipeptides as a nitrogen source revealed common as well as species-unique responses. C. auris induced a significant number of genes with no ortholog in C. albicans, e.g., genes similar to the nicotinic acid transporter TNA1 (alternative carbon sources) and to the oligopeptide transporter (OPT) family (dipeptides). Thus, C. auris possesses unique metabolic features which could have contributed to its emergence as a pathogen. IMPORTANCE Four main clades of the emerging, multidrug-resistant human pathogen Candida auris have been identified, and they differ in their susceptibilities to antifungals and disinfectants. Moreover, clade- and strain-specific metabolic differences have been identified, but a comprehensive overview of nutritional characteristics and resistance to various stressors is missing. Here, we performed high-throughput phenotypic characterization of C. auris on various nutrients, stressors, and chemicals and obtained transcriptomes of cells grown on selected nutrients. The generated data sets identified multiple clade- and strain-specific phenotypes and induction of C. auris-specific metabolic genes, showing unique metabolic properties. The presented work provides a large amount of information for further investigations that could explain the role of metabolism in emergence and pathogenicity of this multidrug-resistant fungus.

Authors: P. Brandt, M. H. Mirhakkak, L. Wagner, D. Driesch, A. Moslinger, P. Fander, S. Schauble, G. Panagiotou, S. Vylkova

Date Published: 15th Jun 2023

Publication Type: Journal

PubMed ID: 37097196

Citation: Microbiol Spectr. 2023 Jun 15;11(3):e0049823. doi: 10.1128/spectrum.00498-23. Epub 2023 Apr 25.

Created: 19th Jan 2024 at 12:10

Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity.

INF, C2, C3

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Innate immune responses vary by pathogen and host genetics. We analyze quantitative trait loci (eQTLs) and transcriptomes of monocytes from 215 individuals stimulated by fungal, Gram-negative or …

Authors: A. Hader, S. Schauble, J. Gehlen, N. Thielemann, B. C. Buerfent, V. Schuller, T. Hess, T. Wolf, J. Schroder, M. Weber, K. Hunniger, J. Loffler, S. Vylkova, G. Panagiotou, J. Schumacher, O. Kurzai

Date Published: 5th Jun 2023

Publication Type: Journal

PubMed ID: 37277347

Citation: Nat Commun. 2023 Jun 5;14(1):3239. doi: 10.1038/s41467-023-38994-5.

Created: 17th Jan 2024 at 10:35

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