Projects
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Gene-engineered CAR T-cells and macrophages to treat Aspergillus fumigatus infection
Integrated database for experimental data
Within the Collaborative Research Center / Transregio 124 “Pathogenic fungi and their human host: Networks of Interaction – FungiNet”, the INF project is responsible to analyse and share OMICS data. Databases help to foster the collaboration within FungiNet as an important point of the Collaborative Research Center. Therefore, we set-up two databases:
a) SEEK is a web-based platform to find, share and exchange unstructured data and knowledge, such as ...
Role and targeting of bioactive lipid mediators in Aspergillus fumigatus innate immune cell interactions
Surface proteins of Lichtheimia corymbifera as virulence determinants
Ionic regulation of Th17-mediated immune responses to Candida infection
Mechanisms of adhesion and modulation of human immune cells by Candida albicans
Role of secreted Candida albicans proteins in immune evasion and pathogenicity
Cross talk of Aspergillus fumigatus with neutrophilic granulocytes
Modelling interactions between the host and fungal pathogens by combining metabolic pathway analysis and evolutionary game theory
Image data analysis and agent-based modelling of the spatio-temporal interaction between immune cells and human-pathogenic fungi
Intrinsic modulation of neutrophil antifungal activity against Candida albicans
Interaction of Aspergillus fumigatus with human natural killer cells, dendritic cells and human alveolar epithelia
In vivo analysis of temporal and spatial disease progression and immune cell recruitment during invasive Aspergillus fumigatus and Candida albicans infections
Molecular mycology, fungal/host interactions, pathogenicity mechanisms of Candida albicans
Regulation of Candida albicans virulence traits by protein kinases
Gastrointestinal colonisation and mechanisms of translocation of Candida albicans through gut mucosa
Interaction networks of signalling molecules and pathways between the pathogenic fungi Aspergillus fumigatus and Candida albicans and their human host
Predictive modelling of host-fungal pathogen interactions by reconstruction of gene regulatory networks
In project Z2 a sophisticated proteome analysis platform will be provided based on 2D-gel electrophoresis (2D-GE), MALDI-TOF and LC-MS/MS techniques to specific A and Cprojects.
Central Tasks
Immunomodulatory functions of ITAM- and ITIM-coupled receptors (C-type lectins/CTLs and carcinoembryonic antigen-related cell adhesion molecules/CEACAMs) for C. albicans -induced immune responses
Impact of regulatory T cells on human infections caused by Aspergillus fumigatus
