Expertise: Not specified
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The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on ...
Projects: FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, A1, A2, A3, A4 (E), A5, B1, B2, B3 (E), B4, C1, C2, C3, C4 (E), C5, C6 (E), Z2, Z1, B5, A6, A7, A8, C7
Web page: http://www.funginet.de/home.html
Image data analysis and agent-based modelling of the spatio-temporal interaction between immune cells and human-pathogenic fungi
This model is a variant of the previously developed SBM of whole-blood infection assay. While in the previous model a spontaneous immune evasion mechanism (A) was implemented in this model immune evasion was caused by PMN molecule secretion (B).
Creators: Teresa Lehnert, Maria T. E. Prauße
Submitter: Sandra Timme
Model type: Not specified
Model format: Not specified
Environment: Not specified
The state-based model (SBM) allow to simulate the interplay between innate immune cells, such as monocytes and PMN, and Candida albicans and to quantify immune reaction rates like phagocytosis and killing rates. It is implemented in C++.
Creator: Teresa Lehnert
Submitter: Sandra Timme
Model type: Not specified
Model format: Not specified
Environment: Not specified
DynaCoSys models the complement system by using a combination of Ordinary and Partial Differential Equations.
Creators: Teresa Lehnert, Alexander Tille
Submitter: Sandra Timme
Model type: Partial differential equations (PDE)
Model format: Not specified
Environment: Not specified
In this model we condider a B cell and its surrounding area and simulate movement and binding of receptors and ligands. The receptors can either be membrane bound (B cell receptors) or soluble (antibodies). Furthermore, receptors can either have a simple spherical shape or a more realistic Y-shape. This allows comparison of the binding dynamics with regard to the dimensionality of motion (membrane-bound vs. soluble), morphology and the binding valency.
Creator: Teresa Lehnert
Submitter: Sandra Timme
Model type: Agent based modelling
Model format: Not specified
Environment: Not specified
Organism: Not specified
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Abstract (Expand)
Authors: A. Tille, T. Lehnert, P. F. Zipfel, M. T. Figge
Date Published: 5th Oct 2020
Publication Type: Not specified
PubMed ID: 33013842
Citation: Front Immunol. 2020 Sep 2;11:1911. doi: 10.3389/fimmu.2020.01911. eCollection 2020.
Abstract (Expand)
Authors: S. Timme, T. Lehnert, M. T. E. Prausse, K. Hunniger, I. Leonhardt, O. Kurzai, M. T. Figge
Date Published: 20th Apr 2018
Publication Type: Not specified
PubMed ID: 29670632
Citation: Front Immunol. 2018 Apr 4;9:667. doi: 10.3389/fimmu.2018.00667. eCollection 2018.
Abstract (Expand)
Authors: M. T. E. Prausse, T. Lehnert, S. Timme, K. Hunniger, I. Leonhardt, O. Kurzai, M. T. Figge
Date Published: 6th Apr 2018
Publication Type: Not specified
PubMed ID: 29619027
Citation: Front Immunol. 2018 Mar 21;9:560. doi: 10.3389/fimmu.2018.00560. eCollection 2018.
Abstract (Expand)
Authors: T. Lehnert, M. T. Figge
Date Published: 19th Dec 2017
Publication Type: Not specified
PubMed ID: 29250071
Citation: Front Immunol. 2017 Nov 30;8:1692. doi: 10.3389/fimmu.2017.01692. eCollection 2017.