Esther Weiß

Overview
Related items

About Esther Weiß:

Doktorandin

Rolle von CD56 in der Interaktion von Natürlichen Killerzellen mit Aspergillus fumigatus

Interaktionsanalysen von humanen Dendritischen Zellen und natürlichen Killerzellen bei der Konfrontation mit Aspergillus fumigatus

SEEK ID: https://funginet.hki-jena.de/people/91

Location: Germany

ORCID: Not specified

Joined: 28th Apr 2016

Expertise: Not specified

Tools: Not specified

Their tags

This person has not yet tagged anything.

Related items

Advanced Programmes list for this Person with search and filtering

Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on ...

Projects: FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, A1, A2, A3, A4 (E), A5, B1, B2, B3 (E), B4, C1, C2, C3, C4 (E), C5, C6 (E), Z2, Z1, B5, A6, A7, A8, C7

Web page: http://www.funginet.de/home.html

Advanced Projects list for this Person with search and filtering

FungiNet total: inactive since 2020-07-31

No description specified

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/home.html

Organisms: Aspergillus fumigatus, Candida albicans

A2: inactive since 2020-07-31

Interaction of Aspergillus fumigatus with human natural killer cells, dendritic cells and human alveolar epithelia

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/project-a2.html

Organisms: Aspergillus fumigatus

Advanced Institutions list for this Person with search and filtering

Julius Maximilians University Würzburg, Department of Internal Medicine II

Country: Germany

City: 97080 Würzburg

Web page: Not specified

Advanced Assays list for this Person with search and filtering

1 hidden item

Advanced Data files list for this Person with search and filtering

1 hidden item

Showing 5 out of a possible 6 Publications Advanced Publications list for this Person with search and filtering

Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels.

INF, A5, C1, C2, B5

(Show All)

Abstract (Expand)

Candida albicans is a leading cause of life-threatening hospital-acquired infections and can lead to Candidemia with sepsis-like symptoms and high mortality rates. We reconstructed a genome-scale C. …

Authors: M. H. Mirhakkak, S. Schauble, T. E. Klassert, S. Brunke, P. Brandt, D. Loos, R. V. Uribe, F. Senne de Oliveira Lino, Y. Ni, S. Vylkova, H. Slevogt, B. Hube, G. J. Weiss, M. O. A. Sommer, G. Panagiotou

Date Published: 15th Dec 2020

Publication Type: Not specified

PubMed ID: 33323978

Citation: ISME J. 2020 Dec 15. pii: 10.1038/s41396-020-00848-z. doi: 10.1038/s41396-020-00848-z.

Created: 9th Feb 2021 at 16:31, Last updated: 17th Jan 2024 at 10:24

Triple RNA-Seq Reveals Synergy in a Human Virus-Fungus Co-infection Model.

INF, A2, B5

(Show All)

Abstract (Expand)

High-throughput RNA sequencing (RNA-seq) is routinely applied to study diverse biological processes; however, when performed separately on interacting organisms, systemic noise intrinsic to RNA extraction, …

Authors: B. Seelbinder, J. Wallstabe, L. Marischen, E. Weiss, S. Wurster, L. Page, C. Loffler, L. Bussemer, A. L. Schmitt, T. Wolf, J. Linde, L. Cicin-Sain, J. Becker, U. Kalinke, J. Vogel, G. Panagiotou, H. Einsele, A. J. Westermann, S. Schauble, J. Loeffler

Date Published: 17th Nov 2020

Publication Type: Not specified

PubMed ID: 33207195

Citation: Cell Rep. 2020 Nov 17;33(7):108389. doi: 10.1016/j.celrep.2020.108389.

Created: 10th Feb 2021 at 12:26, Last updated: 17th Jan 2024 at 10:24

Reconstituting NK Cells After Allogeneic Stem Cell Transplantation Show Impaired Response to the Fungal Pathogen Aspergillus fumigatus.

INF, A2, A3, C3

(Show All)

Abstract (Expand)

Delayed natural killer (NK) cell reconstitution after allogeneic stem cell transplantation (alloSCT) is associated with a higher risk of developing invasive aspergillosis. The interaction of NK cells …

Authors: E. Weiss, J. Schlegel, U. Terpitz, M. Weber, J. Linde, A. L. Schmitt, K. Hunniger, L. Marischen, F. Gamon, J. Bauer, C. Loffler, O. Kurzai, C. O. Morton, M. Sauer, H. Einsele, J. Loeffler

Date Published: 5th Oct 2020

Publication Type: Not specified

PubMed ID: 33013893

Citation: Front Immunol. 2020 Sep 10;11:2117. doi: 10.3389/fimmu.2020.02117. eCollection 2020.

Created: 15th Feb 2021 at 09:54, Last updated: 17th Jan 2024 at 10:24

Aspergillus fumigatus Challenged by Human Dendritic Cells: Metabolic and Regulatory Pathway Responses Testify a Tight Battle.

(Show All)

Abstract (Expand)

Dendritic cells (DCs) are antigen presenting cells which serve as a passage between the innate and the acquired immunity. Aspergillosis is a major lethal condition in immunocompromised patients caused …

Authors: M. Srivastava, E. Bencurova, S. K. Gupta, E. Weiss, J. Loffler, T. Dandekar

Date Published: 14th Jun 2019

Publication Type: Not specified

PubMed ID: 31192161

Citation: Front Cell Infect Microbiol. 2019 May 22;9:168. doi: 10.3389/fcimb.2019.00168. eCollection 2019.

Created: 18th Feb 2021 at 09:48, Last updated: 17th Jan 2024 at 10:24

Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus Aspergillus fumigatus.

FungiNet A - Aspergillus projects

(Show All)

Abstract (Expand)

Aspergillus fumigatus is a common airborne fungal pathogen of humans and a significant source of mortality in immunocompromised individuals. Here, we provide the most extensive cell wall proteome … profiling to date of A. fumigatus resting conidia, the fungal morphotype pertinent to first contact with the host. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), we identified proteins within the conidial cell wall by hydrogen-fluoride (HF)-pyridine extraction and proteins exposed on the surface using a trypsin-shaving approach. One protein, designated conidial cell wall protein A (CcpA), was identified by both methods and was found to be nearly as abundant as hydrophobic rodlet layer-forming protein RodA. CcpA, an amphiphilic protein, like RodA, peaks in expression during sporulation on resting conidia. Despite high cell wall abundance, the cell surface structure of DeltaccpA resting conidia appeared normal. However, trypsin shaving of DeltaccpA conidia revealed novel surface-exposed proteins not detected on conidia of the wild-type strain. Interestingly, the presence of swollen DeltaccpA conidia led to higher activation of neutrophils and dendritic cells than was seen with wild-type conidia and caused significantly less damage to epithelial cells in vitro In addition, virulence was highly attenuated when cortisone-treated, immunosuppressed mice were infected with DeltaccpA conidia. CcpA-specific memory T cell responses were detectable in healthy human donors naturally exposed to A. fumigatus conidia, suggesting a role for CcpA as a structural protein impacting conidial immunogenicity rather than possessing a protein-intrinsic immunosuppressive effect. Together, these data suggest that CcpA serves as a conidial stealth protein by altering the conidial surface structure to minimize innate immune recognition.IMPORTANCE The mammalian immune system relies on recognition of pathogen surface antigens for targeting and clearance. In the absence of immune evasion strategies, pathogen clearance is rapid. In the case of Aspergillus fumigatus, the successful fungus must avoid phagocytosis in the lung to establish invasive infection. In healthy individuals, fungal spores are cleared by immune cells; however, in immunocompromised patients, clearance mechanisms are impaired. Here, using proteome analyses, we identified CcpA as an important fungal spore protein involved in pathogenesis. A. fumigatus lacking CcpA was more susceptible to immune recognition and prompt eradication and, consequently, exhibited drastically attenuated virulence. In infection studies, CcpA was required for virulence in infected immunocompromised mice, suggesting that it could be used as a possible immunotherapeutic or diagnostic target in the future. In summary, our report adds a protein to the list of those known to be critical to the complex fungal spore surface environment and, more importantly, identifies a protein important for conidial immunogenicity during infection.

Authors: V. Voltersen, M. G. Blango, S. Herrmann, F. Schmidt, T. Heinekamp, M. Strassburger, T. Kruger, P. Bacher, J. Lother, E. Weiss, K. Hunniger, H. Liu, P. Hortschansky, A. Scheffold, J. Loffler, S. Krappmann, S. Nietzsche, O. Kurzai, H. Einsele, O. Kniemeyer, S. G. Filler, U. Reichard, A. A. Brakhage

Date Published: 2nd Oct 2018

Publication Type: Not specified

PubMed ID: 30279286

Citation: mBio. 2018 Oct 2;9(5). pii: mBio.01557-18. doi: 10.1128/mBio.01557-18.

Created: 18th Feb 2021 at 14:20, Last updated: 17th Jan 2024 at 10:24

View all 6 Publications

Advanced Presentations list for this Person with search and filtering

4 hidden items