B5

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Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

SEEK ID: https://funginet.hki-jena.de/projects/37

Public web page: http://www.funginet.de/project-b5.html

Organisms: No Organisms specified

INF PALs: No PALs for this Project

Project created: 23rd Feb 2017

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Showing 5 out of a possible 8 People Advanced People list for this Project with search and filtering

Peter Großmann

: inactive since 2020-06-01

Projects: FungiNet total, INF, A1, A2, A3, A4 (E), A5, A6, B1, B3 (E), B4, B5, C1, C2, C3, C4 (E), C5, C6 (E), Z1, Z2, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, B2

Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

https://orcid.org/0000-0001-6106-724X

Expertise: Metabolic networks, Transcriptional Regulation, Bioinformatics, Integrative Data Analysis, Machine Learning, DNA supercoiling

Tools: LaTeX, Matlab, R, Systems biological modelling

Manja Marz

Projects: FungiNet B - Bioinformatics projects, FungiNet total, B5

Institutions: Friedrich Schiller University Jena, Bioinformatics/High Throughput Analysis, Faculty of Mathematics und Computer Science

Expertise: ncRNAs

Mohammad Mirhakkak

Projects: B5, FungiNet B - Bioinformatics projects, FungiNet total

Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

Florian Mock

Projects: B5, FungiNet B - Bioinformatics projects, FungiNet total

Institutions: Friedrich Schiller University Jena, Bioinformatics/High Throughput Analysis, Faculty of Mathematics und Computer Science

https://orcid.org/0000-0002-1791-4437

Expertise: Machine Learning, Bioinformatics, Algorithmics

Gianni Panagiotou

Projects: B5, FungiNet B - Bioinformatics projects, FungiNet total, INF

Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

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Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on ...

Projects: FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, A1, A2, A3, A4 (E), A5, B1, B2, B3 (E), B4, C1, C2, C3, C4 (E), C5, C6 (E), Z2, Z1, B5, A6, A7, A8, C7

Web page: http://www.funginet.de/home.html

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Friedrich Schiller University Jena, Bioinformatics/High Throughput Analysis, Faculty of Mathematics und Computer Science

Country: Germany

City: 07743 Jena

Web page: Not specified

Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

Country: Germany

City: 07745 Jena

Web page: http://www.hki-jena.de

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Showing 5 out of a possible 16 Publications Advanced Publications list for this Project with search and filtering

Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity.

INF, C1, C2, B5

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Abstract (Expand)

Intestinal microbiota dysbiosis can initiate overgrowth of commensal Candida species - a major predisposing factor for disseminated candidiasis. Commensal bacteria such as Lactobacillus rhamnosus can …

Authors: R. Alonso-Roman, A. Last, M. H. Mirhakkak, J. L. Sprague, L. Moller, P. Grossmann, K. Graf, R. Gratz, S. Mogavero, S. Vylkova, G. Panagiotou, S. Schauble, B. Hube, M. S. Gresnigt

Date Published: 9th Jun 2022

Publication Type: Journal

PubMed ID: 35680868

Citation: Nat Commun. 2022 Jun 9;13(1):3192. doi: 10.1038/s41467-022-30661-5.

Created: 19th Jan 2024 at 12:21

Candida albicans SR-Like Protein Kinases Regulate Different Cellular Processes: Sky1 Is Involved in Control of Ion Homeostasis, While Sky2 Is Important for Dipeptide Utilization.

INF, C2, Z2, B5

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Protein kinases play a crucial role in regulating cellular processes such as growth, proliferation, environmental adaptation and stress responses. Serine-arginine (SR) protein kinases are highly conserved …

Authors: P. Brandt, F. Gerwien, L. Wagner, T. Kruger, B. Ramirez-Zavala, M. H. Mirhakkak, S. Schauble, O. Kniemeyer, G. Panagiotou, A. A. Brakhage, J. Morschhauser, S. Vylkova

Date Published: 23rd May 2022

Publication Type: Journal

PubMed ID: 35601106

Citation: Front Cell Infect Microbiol. 2022 May 6;12:850531. doi: 10.3389/fcimb.2022.850531. eCollection 2022.

Created: 19th Jan 2024 at 12:17

MetGEMs Toolbox: Metagenome-scale models as integrative toolbox for uncovering metabolic functions and routes of human gut microbiome.

INF, B5

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Investigating metabolic functional capability of a human gut microbiome enables the quantification of microbiome changes, which can cause a phenotypic change of host physiology and disease. One possible …

Authors: P. Patumcharoenpol, M. Nakphaichit, G. Panagiotou, A. Senavonge, N. Suratannon, W. Vongsangnak

Date Published: 6th Jan 2021

Publication Type: Journal

PubMed ID: 33406089

Citation: PLoS Comput Biol. 2021 Jan 6;17(1):e1008487. doi: 10.1371/journal.pcbi.1008487. eCollection 2021 Jan.

Created: 11th Feb 2021 at 08:17, Last updated: 19th Jan 2024 at 12:06

Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels.

INF, A5, C1, C2, B5

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Candida albicans is a leading cause of life-threatening hospital-acquired infections and can lead to Candidemia with sepsis-like symptoms and high mortality rates. We reconstructed a genome-scale C. …

Authors: M. H. Mirhakkak, S. Schauble, T. E. Klassert, S. Brunke, P. Brandt, D. Loos, R. V. Uribe, F. Senne de Oliveira Lino, Y. Ni, S. Vylkova, H. Slevogt, B. Hube, G. J. Weiss, M. O. A. Sommer, G. Panagiotou

Date Published: 15th Dec 2020

Publication Type: Not specified

PubMed ID: 33323978

Citation: ISME J. 2020 Dec 15. pii: 10.1038/s41396-020-00848-z. doi: 10.1038/s41396-020-00848-z.

Created: 9th Feb 2021 at 16:31, Last updated: 17th Jan 2024 at 10:24

Effects of Agricultural Fungicide Use on Aspergillus fumigatus Abundance, Antifungal Susceptibility, and Population Structure.

INF, B5

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Antibiotic resistance is an increasing threat to human health. In the case of Aspergillus fumigatus, which is both an environmental saprobe and an opportunistic human fungal pathogen, resistance is … suggested to arise from fungicide use in agriculture, as the azoles used for plant protection share the same molecular target as the frontline antifungals used clinically. However, limiting azole fungicide use on crop fields to preserve their activity for clinical use could threaten the global food supply via a reduction in yield. In this study, we clarify the link between azole fungicide use on crop fields and resistance in a prototypical human pathogen through systematic soil sampling on farms in Germany and surveying fields before and after fungicide application. We observed a reduction in the abundance of A. fumigatus on fields following fungicide treatment in 2017, a finding that was not observed on an organic control field with only natural plant protection agents applied. However, this finding was less pronounced during our 2018 sampling, indicating that the impact of fungicides on A. fumigatus population size is variable and influenced by additional factors. The overall resistance frequency among agricultural isolates is low, with only 1 to 3% of isolates from 2016 to 2018 displaying resistance to medical azoles. Isolates collected after the growing season and azole exposure show a subtle but consistent decrease in susceptibility to medical and agricultural azoles. Whole-genome sequencing indicates that, despite the alterations in antifungal susceptibility, fungicide application does not significantly affect the population structure and genetic diversity of A. fumigatus in fields. Given the low observed resistance rate among agricultural isolates as well the lack of genomic impact following azole application, we do not find evidence that azole use on crops is significantly driving resistance in A. fumigatus in this context.IMPORTANCE Antibiotic resistance is an increasing threat to human health. In the case of Aspergillus fumigatus, which is an environmental fungus that also causes life-threatening infections in humans, antimicrobial resistance is suggested to arise from fungicide use in agriculture, as the chemicals used for plant protection are almost identical to the antifungals used clinically. However, removing azole fungicides from crop fields threatens the global food supply via a reduction in yield. In this study, we survey crop fields before and after fungicide application. We find a low overall azole resistance rate among agricultural isolates, as well as a lack of genomic and population impact following fungicide application, leading us to conclude azole use on crops does not significantly contribute to resistance in A. fumigatus.

Authors: A. E. Barber, J. Riedel, T. Sae-Ong, K. Kang, W. Brabetz, G. Panagiotou, H. B. Deising, O. Kurzai

Date Published: 24th Nov 2020

Publication Type: Not specified

PubMed ID: 33234685

Citation: mBio. 2020 Nov 24;11(6). pii: mBio.02213-20. doi: 10.1128/mBio.02213-20.

Created: 11th Feb 2021 at 08:59, Last updated: 17th Jan 2024 at 10:24

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