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Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

SEEK ID: https://funginet.hki-jena.de/projects/11

Public web page: http://www.funginet.de/home.html

Organisms: Aspergillus fumigatus, Candida albicans

INF PALs: No PALs for this Project

Project created: 1st Oct 2012

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Showing 5 out of a possible 98 People Advanced People list for this Project with search and filtering

Stefanie Allert

Projects: C1, FungiNet C - Candida projects, FungiNet total

Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

Svitlana Babych

Projects: C4 (E), FungiNet C - Candida projects, FungiNet total

Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

Johannes Balkenhol

Projects: B2, FungiNet B - Bioinformatics projects, FungiNet total, B1

Institutions: Julius Maximilians University Würzburg, Biocenter, Department of Bioinformatics

johannes.balkenhol@uni-wuerzburg.de vorher: johannes.balkenhol@stud-mail.uni-wuerzburg.de

Michael Bauer

Projects: FungiNet C - Candida projects, FungiNet total, C5

Institutions: University Hospital Jena, Clinic for Anesthesiology and Intensive Care Medicine

Nicole Becher

Projects: FungiNet total

Institutions: Friedrich-Schiller-University

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Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on ...

Projects: FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, A1, A2, A3, A4 (E), A5, B1, B2, B3 (E), B4, C1, C2, C3, C4 (E), C5, C6 (E), Z2, Z1, B5, A6, A7, A8, C7

Web page: http://www.funginet.de/home.html

Showing 5 out of a possible 20 Institutions Advanced Institutions list for this Project with search and filtering

Friedrich Schiller University Jena, Center for Innovation Competence (ZIK) Septomics

Country: Germany

City: 07745 Jena

Web page: Not specified

Friedrich Schiller University Jena, Jena School for Microbial Communication

Country: Germany

City: 07743 Jena

Web page: Not specified

Friedrich Schiller University Jena, Bioinformatics/High Throughput Analysis, Faculty of Mathematics und Computer Science

Country: Germany

City: 07743 Jena

Web page: Not specified

Friedrich Schiller University Jena, Center For Molecular Biomedicine (CMB)

Country: Germany

City: Jena

Web page: http://www.cmb.uni-jena.de/

Friedrich Schiller University Jena, Chair MIcrobial Pathogenicity

Country: Germany

City: 07745 Jena

Web page: Not specified

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5th Joint Meeting IMIHM XII & CRC/TR 124

FungiNet total

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Programme

Creators: Thomas Wolf, Jürgen Löffler, Annika Tittelbach-Helmrich

Submitter: Thomas Wolf

Investigations: No Investigations

Studies: No Studies

Assays: No Assays

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Created: 7th Jun 2018 at 07:45, Last updated: 12th Jun 2018 at 11:31

Annual Meeting CRC/TR 124 FungiNet - 2014 - Program

FungiNet total

No description specified

Creator: Reinhard Guthke

Submitter: Reinhard Guthke

Investigations: No Investigations

Studies: No Studies

Assays: No Assays

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Created: 4th Mar 2016 at 12:45, Last updated: 7th Jun 2018 at 15:41

DMykG_2015 Programmheft

FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, Z2

No description specified

Creator: Reinhard Guthke

Submitter: Reinhard Guthke

Investigations: No Investigations

Studies: No Studies

Assays: No Assays

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Created: 4th Mar 2016 at 16:00, Last updated: 7th Jun 2018 at 15:41

DMykG 2015 Programmheft

FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, Z2

No description specified

Creator: Reinhard Guthke

Submitter: Reinhard Guthke

Investigations: No Investigations

Studies: No Studies

Assays: No Assays

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Created: 4th Mar 2016 at 16:02, Last updated: 7th Jun 2018 at 15:41

Sample File "FungiNet_template_RNA-seq_V1.9_Ex_ID_005"

FungiNet total, A1

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Cultivation of A. fumigatus in an O2-controlled fermenter and analysed its minute-scale responses to O2 limitation. Transcriptome sequencing revealed a group of genes underlying a rapid and highly dynamic regulation.

Creators: Jörg Linde, Falk Hillmann, Olaf Kniemeyer

Submitter: Maja Rey

Investigations: 1 hidden item

Studies: 1 hidden item

Assays: 1 hidden item

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Created: 5th Sep 2017 at 09:21, Last updated: 4th Jun 2018 at 12:41

22 hidden items

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[DEMO] Response of hepatocytes to rapid change in the medium composition (gene regulatory network): Model 1100 "freshMedia"

FungiNet total, FungiNet B - Bioinformatics projects

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Primary hepatocytes were exposed to a stimulus by exchanging culture medium, thereby simulating changes in the blood composition. The expression of genes at different time points was recorded. Differentially expressed genes were clustered using fuzzy c-means algorithm into five groups. The arcs of the possible network were identified using the NetGenerator algorithm under the restriction of biological knowledge. The analysis was restricted to the main metabolic pathways of hepatocytes. The reverse ...

Creators: Thomas Wolf, Wolfgang Schmidt-Heck, Reinhard Guthke

Submitter: Thomas Wolf

Model type: Ordinary differential equations (ODE)

Model format: SBML

Environment: JWS Online

Organism: Not specified

Investigations: No Investigations

Studies: No Studies

Assays: No Assays

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Created: 6th Jun 2017 at 07:38, Last updated: 27th Feb 2018 at 13:25

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Showing 5 out of a possible 10 Publications Advanced Publications list for this Project with search and filtering

Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA.

FungiNet total, A1, Z2

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Filamentous fungi of the genus Aspergillus are of particular interest for biotechnological applications due to their natural capacity to secrete carbohydrate-active enzymes (CAZy) that target plant … biomass. The presence of easily metabolizable sugars such as glucose, whose concentrations increase during plant biomass hydrolysis, results in the repression of CAZy-encoding genes in a process known as carbon catabolite repression (CCR), which is undesired for the purpose of large-scale enzyme production. To date, the C2H2 transcription factor CreA has been described as the major CC repressor in Aspergillus spp., although little is known about the role of posttranslational modifications in this process. In this work, phosphorylation sites were identified by mass spectrometry on Aspergillus nidulans CreA, and subsequently, the previously identified but uncharacterized site S262, the characterized site S319, and the newly identified sites S268 and T308 were chosen to be mutated to nonphosphorylatable residues before their effect on CCR was investigated. Sites S262, S268, and T308 are important for CreA protein accumulation and cellular localization, DNA binding, and repression of enzyme activities. In agreement with a previous study, site S319 was not important for several here-tested phenotypes but is key for CreA degradation and induction of enzyme activities. All sites were shown to be important for glycogen and trehalose metabolism. This study highlights the importance of CreA phosphorylation sites for the regulation of CCR. These sites are interesting targets for biotechnological strain engineering without the need to delete essential genes, which could result in undesired side effects.IMPORTANCE In filamentous fungi, the transcription factor CreA controls carbohydrate metabolism through the regulation of genes encoding enzymes required for the use of alternative carbon sources. In this work, phosphorylation sites were identified on Aspergillus nidulans CreA, and subsequently, the two newly identified sites S268 and T308, the previously identified but uncharacterized site S262, and the previously characterized site S319 were chosen to be mutated to nonphosphorylatable residues before their effect on CCR was characterized. Sites S262, S268, and T308 are important for CreA protein accumulation and cellular localization, DNA binding, and repression of enzyme activities. In agreement with a previous study, site S319 is not important for several here-tested phenotypes but is key for CreA degradation and induction of enzyme activities. This work characterized novel CreA phosphorylation sites under carbon catabolite-repressing conditions and showed that they are crucial for CreA protein turnover, control of carbohydrate utilization, and biotechnologically relevant enzyme production.

Authors: L. J. de Assis, L. P. Silva, O. Bayram, P. Dowling, O. Kniemeyer, T. Kruger, A. A. Brakhage, Y. Chen, L. Dong, K. Tan, K. H. Wong, L. N. A. Ries, G. H. Goldman

Date Published: 5th Jan 2021

Publication Type: Not specified

PubMed ID: 33402538

Citation: mBio. 2021 Jan 5;12(1). pii: mBio.03146-20. doi: 10.1128/mBio.03146-20.

Created: 15th Feb 2021 at 09:23, Last updated: 17th Jan 2024 at 10:24

Unaltered Fungal Burden and Lethality in Human CEACAM1-Transgenic Mice During Candida albicans Dissemination and Systemic Infection.

FungiNet total, A5

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Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1, CD66a) is a receptor for Candida albicans. It is crucial for the immune response of intestinal epithelial cells to this opportunistic …

Authors: E. Klaile, M. M. Muller, C. Zubiria-Barrera, S. Brehme, T. E. Klassert, M. Stock, A. Durotin, T. D. Nguyen, S. Feer, B. B. Singer, P. F. Zipfel, S. Rudolphi, I. D. Jacobsen, H. Slevogt

Date Published: 19th Dec 2019

Publication Type: Not specified

PubMed ID: 31849868

Citation: Front Microbiol. 2019 Nov 26;10:2703. doi: 10.3389/fmicb.2019.02703. eCollection 2019.

Created: 16th Feb 2021 at 16:43, Last updated: 17th Jan 2024 at 10:24

Trends in mathematical modeling of host-pathogen interactions.

FungiNet total, B1

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Pathogenic microorganisms entail enormous problems for humans, livestock, and crop plants. A better understanding of the different infection strategies of the pathogens enables us to derive optimal …

Authors: J. Ewald, P. Sieber, R. Garde, S. N. Lang, S. Schuster, B. Ibrahim

Date Published: 30th Nov 2019

Publication Type: Not specified

PubMed ID: 31776589

Citation: Cell Mol Life Sci. 2020 Feb;77(3):467-480. doi: 10.1007/s00018-019-03382-0. Epub 2019 Nov 27.

Created: 17th Feb 2021 at 14:57, Last updated: 17th Jan 2024 at 10:24

Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies.

FungiNet total, FungiNet C - Candida projects, C4 (E)

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Abstract (Expand)

Persistent inflammation is a hallmark of many human diseases, including anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and atherosclerosis. Here, we describe a dominant trigger of …

Authors: S. Irmscher, S. R. Brix, S. L. H. Zipfel, L. D. Halder, S. Mutluturk, S. Wulf, E. Girdauskas, H. Reichenspurner, R. A. K. Stahl, B. Jungnickel, T. Wiech, P. F. Zipfel, C. Skerka

Date Published: 4th Jul 2019

Publication Type: Not specified

PubMed ID: 31273197

Citation: Nat Commun. 2019 Jul 4;10(1):2961. doi: 10.1038/s41467-019-10766-0.

Created: 18th Feb 2021 at 11:32, Last updated: 17th Jan 2024 at 10:24

N-Acetylglucosamine-Induced Cell Death in Candida albicans and Its Implications for Adaptive Mechanisms of Nutrient Sensing in Yeasts.

FungiNet total, FungiNet C - Candida projects

Abstract (Expand)

UNLABELLED: Single-celled organisms have different strategies to sense and utilize nutrients in their ever-changing environments. The opportunistic fungal pathogen Candida albicans is a common member … of the human microbiota, especially that of the gastrointestinal (GI) tract. An important question concerns how C. albicans gained a competitive advantage over other microbes to become a successful commensal and opportunistic pathogen. Here, we report that C. albicans uses N-acetylglucosamine (GlcNAc), an abundant carbon source present in the GI tract, as a signal for nutrient availability. When placed in water, C. albicans cells normally enter the G0 phase and remain viable for weeks. However, they quickly lose viability when cultured in water containing only GlcNAc. We term this phenomenon GlcNAc-induced cell death (GICD). GlcNAc triggers the upregulation of ribosomal biogenesis genes, alterations of mitochondrial metabolism, and the accumulation of reactive oxygen species (ROS), followed by rapid cell death via both apoptotic and necrotic mechanisms. Multiple pathways, including the conserved cyclic AMP (cAMP) signaling and GlcNAc catabolic pathways, are involved in GICD. GlcNAc acts as a signaling molecule to regulate multiple cellular programs in a coordinated manner and therefore maximizes the efficiency of nutrient use. This adaptive behavior allows C. albicans' more efficient colonization of the gut. IMPORTANCE: The ability to rapidly and appropriately respond to nutrients in the environment is crucial to free-living microorganisms. To maximize the use of available nutrients, microorganisms often use a limiting nutritional component as a signal to coordinate multiple biological processes. The human fungal pathogen Candida albicans uses N-acetylglucosamine (GlcNAc) as a signal for the availability of external nutrient resources. GlcNAc induces rapid cell death in C. albicans due to the constitutive activation of oxidative metabolism and accumulation of reactive oxygen species (ROS), and multiple pathways are involved in its regulation. This study sheds light on the mechanisms of niche specialization of pathogenic fungi and raises the possibility that this cell death pathway could be an unexplored therapeutic target.

Authors: H. Du, G. Guan, X. Li, M. Gulati, L. Tao, C. Cao, A. D. Johnson, C. J. Nobile, G. Huang

Date Published: 10th Sep 2015

Publication Type: Not specified

PubMed ID: 26350972

Citation: MBio. 2015 Sep 8;6(5):e01376-15. doi: 10.1128/mBio.01376-15.

Created: 25th Sep 2017 at 10:53, Last updated: 17th Jan 2024 at 10:24

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C3 - Modulation of neutrophil antifungal activity by intrinsic and extrinsic stimuli

FungiNet total, FungiNet C - Candida projects, C3

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Creator: Kerstin Hünniger

Submitter: Kerstin Hünniger

Created: 27th Apr 2022 at 08:10, Last updated: 27th Apr 2022 at 08:13

On the role of CEACAM receptors during systemic candidiasis

FungiNet total, FungiNet A - Aspergillus projects, A5

No description specified

Creator: Esther Klaile

Submitter: Esther Klaile

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Created: 2nd Mar 2022 at 09:52

Molecular characterization of Candida albicans mucosal colonization, infection and translocation

FungiNet total

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Talk at internal seminar in Jena_21.11.2017

Creators: Toni Förster, Selene Mogavero, Bernhard Hube, Lydia Kasper, Stefanie Allert

Submitter: Toni Förster

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Created: 27th Nov 2017 at 15:36, Last updated: 27th Feb 2018 at 13:25

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Annual Meeting CRC/TR 124 FungiNet 2018

No description specified

Start Date: 19th Nov 2018

End Date: 20th Nov 2018

Event Website: Not specified

Country: Germany

City: Bad Staffelstein

Created: 20th Nov 2018 at 15:33, Last updated: 26th Nov 2018 at 13:18

Joint Meeting IMIHM XII & CRC/TR 124 2018-06

This year's 12th IMIHM meeting is held for the fifth time as a Joint Meeting together with scientists from the CRC TransRegio 124 (“Pathogenic fungi and their human host: Networks of interaction – FungiNet”). This collaborative Research Centre FungiNet is a network of scientists from Jena and Wuerzburg and is funded by the Deutsche Forschungsgemeinschaft. The Consortium collaborates to better understand complex invasive mycoses by investigating the pathobiology of fungi, the response of the immune ...

Start Date: 26th Jun 2018

End Date: 27th Jun 2018

Event Website: Not specified

Country: Germany

City: Würzburg

Created: 7th Jun 2018 at 07:45, Last updated: 26th Nov 2018 at 13:32

Joint Meeting IMIHM XI & CRC/TR 124 - September 2017

This year‘s 11 th IMIHM meeting is held for the fourth time as a Joint Meeting together with scientists from the CRC TransRegio 124 (“Pathogenic fungi and their human host: Networks of interaction – FungiNet”). This Collaborative Research Centre FungiNet is a network of scientists from Jena and Wuerzburg and is funded by the Deutsche Forschungsgemeinschaft. The Consortium collaborates to better understand complex invasive mycoses by investigating the pathobiology of fungi, the response of the ...

Start Date: 7th Sep 2017

End Date: 8th Sep 2017

Event Website: Not specified

Country: Germany

City: Würzburg

Created: 5th Sep 2017 at 11:24, Last updated: 27th Feb 2018 at 13:25

SFB FungiNet: Review Meeting in Würburg

No description specified

Start Date: 9th Feb 2017

End Date: 10th Feb 2017

Event Website: Not specified

Country: Germany