Jan Ewald
SEEK ID: https://funginet.hki-jena.de/people/80
Location:
Germany
ORCID:
https://orcid.org/0000-0002-9415-2317
Joined: 21st Mar 2016
Expertise: Mathematical Modelling, Systems Biology, Metabolic networks
Tools: Systems biological modelling, Matlab, Python, R, LaTeX
Their tagsRelated items
The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on ...
Projects: FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, A1, A2, A3, A4 (E), A5, B1, B2, B3 (E), B4, C1, C2, C3, C4 (E), C5, C6 (E), Z2, Z1, B5, A6, A7, A8, C7
Web page: http://www.funginet.de/home.html
Modelling interactions between the host and fungal pathogens by combining metabolic pathway analysis and evolutionary game theory
Interaction networks of signalling molecules and pathways between the pathogenic fungi Aspergillus fumigatus and Candida albicans and their human host
Dynamic optimization model to study control points in metabolic pathways to identify general strategies behind pathway regulation. Toxic intermediates determine which enzyme control pathway flux and prevent their accumulation. Therefore those enzymes are drug targets since deregulation leads to self-poisoning of pathogens.
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Abstract (Expand)
Authors: R. Garde, J. Ewald, A. T. Kovacs, S. Schuster
Date Published: 3rd Nov 2020
Publication Type: Not specified
Abstract (Expand)
Authors: J. Ewald, P. Sieber, R. Garde, S. N. Lang, S. Schuster, B. Ibrahim
Date Published: 30th Nov 2019
Publication Type: Not specified
Abstract (Expand)
Authors: M. Srivastava, E. Bencurova, S. K. Gupta, E. Weiss, J. Loffler, T. Dandekar
Date Published: 14th Jun 2019
Publication Type: Not specified
Abstract (Expand)
Authors: S. N. Lang, S. Germerodt, C. Glock, C. Skerka, P. F. Zipfel, S. Schuster
Date Published: 20th Feb 2019
Publication Type: Not specified
Abstract (Expand)
Authors: S. Hummert, C. Glock, S. N. Lang, C. Hummert, C. Skerka, P. F. Zipfel, S. Germerodt, S. Schuster
Date Published: 4th May 2018
Publication Type: Not specified
