Interaction networks of signalling molecules and pathways between the pathogenic fungi Aspergillus fumigatus and Candida albicans and their human host
Dynamic optimization model to study control points in metabolic pathways to identify general strategies behind pathway regulation.
Toxic intermediates determine which enzyme control pathway flux and prevent their accumulation.
Therefore those enzymes are drug targets since deregulation leads to self-poisoning of pathogens.
Creator: Jan Ewald
Contributor: Jan Ewald
Model type: Ordinary differential equations (ODE)
Model format: Matlab package
Environment: Not specified
Organism: Not specified
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
Date Published: 30th Jul 2017
Journal: Biochem Soc Trans
PubMed ID: 28754658
Citation: Biochem Soc Trans. 2017 Jul 28. pii: BST20170137. doi: 10.1042/BST20170137.
Date Published: 18th Feb 2017
Journal: PLoS Comput Biol
PubMed ID: 28212377
Citation: PLoS Comput Biol. 2017 Feb 17;13(2):e1005371. doi: 10.1371/journal.pcbi.1005371. eCollection 2017 Feb.
Date Published: 16th May 2015
Journal: BMC Bioinformatics
PubMed ID: 25982966
Date Published: 1st May 2015
PubMed ID: 25927816