FungiNet C - Candida projects

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Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

SEEK ID: https://funginet.hki-jena.de/projects/17

Public web page: http://www.funginet.de/project-area-c.html

Organisms: Candida albicans

INF PALs: No PALs for this Project

Project created: 1st Oct 2012

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Showing 5 out of a possible 46 People Advanced People list for this Project with search and filtering

Stefanie Allert

Projects: C1, FungiNet C - Candida projects, FungiNet total

Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

Svitlana Babych

Projects: C4 (E), FungiNet C - Candida projects, FungiNet total

Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

Michael Bauer

Projects: FungiNet C - Candida projects, FungiNet total, C5

Institutions: University Hospital Jena, Clinic for Anesthesiology and Intensive Care Medicine

Niklas Beyersdorf

Projects: FungiNet C - Candida projects, FungiNet total, C6 (E)

Institutions: Julius Maximilians University Würzburg, Institute for Virology and Immunobiology

Sally Böde

Projects: FungiNet C - Candida projects, C4 (E), FungiNet total

Institutions: Friedrich Schiller University Jena, Center For Molecular Biomedicine (CMB)

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Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on ...

Projects: FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, A1, A2, A3, A4 (E), A5, B1, B2, B3 (E), B4, C1, C2, C3, C4 (E), C5, C6 (E), Z2, Z1, B5, A6, A7, A8, C7

Web page: http://www.funginet.de/home.html

Showing 5 out of a possible 19 Institutions Advanced Institutions list for this Project with search and filtering

Friedrich Schiller University Jena, Center for Innovation Competence (ZIK) Septomics

Country: Germany

City: 07745 Jena

Web page: Not specified

Friedrich Schiller University Jena, Jena School for Microbial Communication

Country: Germany

City: 07743 Jena

Web page: Not specified

Friedrich Schiller University Jena, Bioinformatics/High Throughput Analysis, Faculty of Mathematics und Computer Science

Country: Germany

City: 07743 Jena

Web page: Not specified

Friedrich Schiller University Jena, Center For Molecular Biomedicine (CMB)

Country: Germany

City: Jena

Web page: http://www.cmb.uni-jena.de/

Friedrich Schiller University Jena, Chair MIcrobial Pathogenicity

Country: Germany

City: 07745 Jena

Web page: Not specified

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DMykG_2015 Programmheft

FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, Z2

No description specified

Creator: Reinhard Guthke

Submitter: Reinhard Guthke

Investigations: No Investigations

Studies: No Studies

Assays: No Assays

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Created: 4th Mar 2016 at 16:00, Last updated: 7th Jun 2018 at 15:41

DMykG 2015 Programmheft

FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, Z2

No description specified

Creator: Reinhard Guthke

Submitter: Reinhard Guthke

Investigations: No Investigations

Studies: No Studies

Assays: No Assays

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Created: 4th Mar 2016 at 16:02, Last updated: 7th Jun 2018 at 15:41

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Showing 5 out of a possible 58 Publications Advanced Publications list for this Project with search and filtering

Significant Differences in Host-Pathogen Interactions Between Murine and Human Whole Blood.

FungiNet C - Candida projects, C5

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Abstract (Expand)

Murine infection models are widely used to study systemic candidiasis caused by C. albicans. Whole-blood models can help to elucidate host-pathogens interactions and have been used for several Candida …

Authors: S. Machata, S. Sreekantapuram, K. Hunniger, O. Kurzai, C. Dunker, K. Schubert, W. Kruger, B. Schulze-Richter, C. Speth, G. Rambach, I. D. Jacobsen

Date Published: 1st Feb 2021

Publication Type: Not specified

PubMed ID: 33519798

Citation: Front Immunol. 2021 Jan 15;11:565869. doi: 10.3389/fimmu.2020.565869. eCollection 2020.

Created: 19th Feb 2021 at 16:08, Last updated: 17th Jan 2024 at 10:24

Molecular analyses identifies new domains and structural differences among Streptococcus pneumoniae immune evasion proteins PspC and Hic.

FungiNet C - Candida projects, C6 (E)

Abstract (Expand)

The PspC and Hic proteins of Streptococcus pneumoniae are some of the most variable microbial immune evasion proteins identified to date. Due to structural similarities and conserved binding profiles, …

Authors: S. Du, C. Vilhena, S. King, A. Sahagun-Ruiz, S. Hammerschmidt, C. Skerka, P. F. Zipfel

Date Published: 18th Jan 2021

Publication Type: Not specified

PubMed ID: 33462258

Citation: Sci Rep. 2021 Jan 18;11(1):1701. doi: 10.1038/s41598-020-79362-3.

Created: 19th Feb 2021 at 08:51, Last updated: 17th Jan 2024 at 10:24

Active neutrophil responses counteract Candida albicans burn wound infection of ex vivo human skin explants.

FungiNet C - Candida projects, C2

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Burn wounds are highly susceptible sites for colonization and infection by bacteria and fungi. Large wound surface, impaired local immunity, and broad-spectrum antibiotic therapy support growth of …

Authors: C. von Muller, F. Bulman, L. Wagner, D. Rosenberger, A. Marolda, O. Kurzai, P. Eissmann, I. D. Jacobsen, B. Perner, P. Hemmerich, S. Vylkova

Date Published: 11th Dec 2020

Publication Type: Not specified

PubMed ID: 33311597

Citation: Sci Rep. 2020 Dec 11;10(1):21818. doi: 10.1038/s41598-020-78387-y.

Created: 19th Feb 2021 at 08:22, Last updated: 17th Jan 2024 at 10:24

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.

FungiNet C - Candida projects, C5

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Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial barriers …

Authors: C. d'Enfert, A. K. Kaune, L. R. Alaban, S. Chakraborty, N. Cole, M. Delavy, D. Kosmala, B. Marsaux, R. Frois-Martins, M. Morelli, D. Rosati, M. Valentine, Z. Xie, Y. Emritloll, P. A. Warn, F. Bequet, M. E. Bougnoux, S. Bornes, M. S. Gresnigt, B. Hube, I. D. Jacobsen, M. Legrand, S. Leibundgut-Landmann, C. Manichanh, C. A. Munro, M. G. Netea, K. Queiroz, K. Roget, V. Thomas, C. Thoral, P. Van den Abbeele, A. W. Walker, A. J. P. Brown

Date Published: 24th Nov 2020

Publication Type: Not specified

PubMed ID: 33232448

Citation: FEMS Microbiol Rev. 2020 Nov 24. pii: 6000215. doi: 10.1093/femsre/fuaa060.

Created: 19th Feb 2021 at 16:11, Last updated: 17th Jan 2024 at 10:24

Quantification of Factor H Mediated Self vs. Non-self Discrimination by Mathematical Modeling.

FungiNet C - Candida projects, B4

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The complement system is part of the innate immune system and plays an important role in the host defense against infectious pathogens. One of the main effects is the opsonization of foreign invaders … and subsequent uptake by phagocytosis. Due to the continuous default basal level of active complement molecules, a tight regulation is required to protect the body's own cells (self cells) from opsonization and from complement damage. A major complement regulator is Factor H, which is recruited from the fluid phase and attaches to cell surfaces where it effectively controls complement activation. Besides self cells, pathogens also have the ability to bind Factor H; they can thus escape opsonization and phagocytosis causing severe infections. In order to advance our understanding of the opsonization process at a quantitative level, we developed a mathematical model for the dynamics of the complement system-termed DynaCoSys model-that is based on ordinary differential equations for cell surface-bound molecules and on partial differential equations for concentration profiles of the fluid phase molecules in the environment of cells. This hybrid differential equation approach allows to model the complement cascade focusing on the role of active C3b in the fluid phase and on the cell surface as well as on its inactivation on the cell surface. The DynaCoSys model enables us to quantitatively predict the conditions under which Factor H mediated complement evasion occurs. Furthermore, investigating the quantitative impact of model parameters by a sensitivity analysis, we identify the driving processes of complement activation and regulation in both the self and non-self regime. The two regimes are defined by a critical Factor H concentration on the cell surface and we use the model to investigate the differential impact of complement model parameters on this threshold value. The dynamic modeling on the surface of pathogens are further relevant to understand pathophysiological situations where Factor H mutants and defective Factor H binding to target surfaces results in pathophysiology such as renal and retinal disease. In the future, this DynaCoSys model will be extended to also enable evaluating treatment strategies of complement-related diseases.

Authors: A. Tille, T. Lehnert, P. F. Zipfel, M. T. Figge

Date Published: 5th Oct 2020

Publication Type: Not specified

PubMed ID: 33013842

Citation: Front Immunol. 2020 Sep 2;11:1911. doi: 10.3389/fimmu.2020.01911. eCollection 2020.

Created: 16th Feb 2021 at 16:08, Last updated: 17th Jan 2024 at 10:24

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C3 - Modulation of neutrophil antifungal activity by intrinsic and extrinsic stimuli

FungiNet total, FungiNet C - Candida projects, C3