C1

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Molecular mycology, fungal/host interactions, pathogenicity mechanisms of Candida albicans

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

SEEK ID: https://funginet.hki-jena.de/projects/28

Public web page: http://www.funginet.de/project-c1.html

Organisms: Candida albicans, Homo sapiens, Candida glabrata, Candida parapsilosis, Candida tropicalis

INF PALs: No PALs for this Project

Project created: 21st Jul 2015

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Showing 5 out of a possible 14 People Advanced People list for this Project with search and filtering

Stefanie Allert

Projects: C1, FungiNet C - Candida projects, FungiNet total

Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

Toni Förster

Projects: FungiNet C - Candida projects, FungiNet total, C1

Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

Project C1

Mark Gresnigt

Projects: C1

Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

https://orcid.org/0000-0002-9514-4634

Expertise: Immunology, Host-Pathogen Interaction, Immune evasion

Peter Großmann

: inactive since 2020-06-01

Projects: FungiNet total, INF, A1, A2, A3, A4 (E), A5, A6, B1, B3 (E), B4, B5, C1, C2, C3, C4 (E), C5, C6 (E), Z1, Z2, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, B2

Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

https://orcid.org/0000-0001-6106-724X

Expertise: Metabolic networks, Transcriptional Regulation, Bioinformatics, Integrative Data Analysis, Machine Learning, DNA supercoiling

Tools: LaTeX, Matlab, R, Systems biological modelling

Bernhard Hube

Projects: FungiNet total, FungiNet C - Candida projects, C1

Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI), Friedrich Schiller University Jena, Chair MIcrobial Pathogenicity

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Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on ...

Projects: FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, A1, A2, A3, A4 (E), A5, B1, B2, B3 (E), B4, C1, C2, C3, C4 (E), C5, C6 (E), Z2, Z1, B5, A6, A7, A8, C7

Web page: http://www.funginet.de/home.html

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HITS Heidelberger Institut für Theoretische Studien gGmbH

Country: Germany

City: Heidelberg

Web page: https://www.h-its.org

Julius Maximilians University Würzburg, Institute for Molecular Infection Biology

Country: Germany

City: Würzburg

Web page: http://www.imib-wuerzburg.de/imib

Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

Country: Germany

City: 07745 Jena

Web page: http://www.hki-jena.de

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Showing 5 out of a possible 11 Publications Advanced Publications list for this Project with search and filtering

Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity.

INF, C1, C2, B5

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Abstract (Expand)

Intestinal microbiota dysbiosis can initiate overgrowth of commensal Candida species - a major predisposing factor for disseminated candidiasis. Commensal bacteria such as Lactobacillus rhamnosus can …

Authors: R. Alonso-Roman, A. Last, M. H. Mirhakkak, J. L. Sprague, L. Moller, P. Grossmann, K. Graf, R. Gratz, S. Mogavero, S. Vylkova, G. Panagiotou, S. Schauble, B. Hube, M. S. Gresnigt

Date Published: 9th Jun 2022

Publication Type: Journal

PubMed ID: 35680868

Citation: Nat Commun. 2022 Jun 9;13(1):3192. doi: 10.1038/s41467-022-30661-5.

Created: 19th Jan 2024 at 12:21

From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris.

INF, C1

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Abstract (Expand)

Candida species are a major cause of invasive fungal infections. While Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis are the most dominant species causing life-threatening candidiasis, …

Authors: S. Allert, D. Schulz, P. Kammer, P. Grossmann, T. Wolf, S. Schauble, G. Panagiotou, S. Brunke, B. Hube

Date Published: 10th Feb 2022

Publication Type: Journal

PubMed ID: 35142597

Citation: Virulence. 2022 Dec;13(1):191-214. doi: 10.1080/21505594.2022.2026037.

Created: 19th Jan 2024 at 12:15

Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels.

INF, A5, C1, C2, B5

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Candida albicans is a leading cause of life-threatening hospital-acquired infections and can lead to Candidemia with sepsis-like symptoms and high mortality rates. We reconstructed a genome-scale C. …

Authors: M. H. Mirhakkak, S. Schauble, T. E. Klassert, S. Brunke, P. Brandt, D. Loos, R. V. Uribe, F. Senne de Oliveira Lino, Y. Ni, S. Vylkova, H. Slevogt, B. Hube, G. J. Weiss, M. O. A. Sommer, G. Panagiotou

Date Published: 15th Dec 2020

Publication Type: Not specified

PubMed ID: 33323978

Citation: ISME J. 2020 Dec 15. pii: 10.1038/s41396-020-00848-z. doi: 10.1038/s41396-020-00848-z.

Created: 9th Feb 2021 at 16:31, Last updated: 17th Jan 2024 at 10:24

Lysosome Fusion Maintains Phagosome Integrity during Fungal Infection.

Abstract (Expand)

Phagosomes must maintain membrane integrity to exert their microbicidal function. Some microorganisms, however, survive and grow within phagosomes. In such instances, phagosomes must expand to avoid …

Authors: J. Westman, G. F. W. Walpole, L. Kasper, B. Y. Xue, O. Elshafee, B. Hube, S. Grinstein

Date Published: 9th Dec 2020

Publication Type: Not specified

PubMed ID: 33022213

Citation: Cell Host Microbe. 2020 Dec 9;28(6):798-812.e6. doi: 10.1016/j.chom.2020.09.004. Epub 2020 Oct 5.

Created: 16th Feb 2021 at 11:58, Last updated: 17th Jan 2024 at 10:24

Survival Strategies of Pathogenic Candida Species in Human Blood Show Independent and Specific Adaptations.

INF, B3 (E), C1, C3

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Only four species, Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis, together account for about 90% of all Candida bloodstream infections and are among the most common causes of invasive … fungal infections of humans. However, virulence potential varies among these species, and the phylogenetic tree reveals that their pathogenicity may have emerged several times independently during evolution. We therefore tested these four species in a human whole-blood infection model to determine, via comprehensive dual-species RNA-sequencing analyses, which fungal infection strategies are conserved and which are recent evolutionary developments. The ex vivo infection progressed from initial immune cell interactions to nearly complete killing of all fungal cells. During the course of infection, we characterized important parameters of pathogen-host interactions, such as fungal survival, types of interacting immune cells, and cytokine release. On the transcriptional level, we obtained a predominantly uniform and species-independent human response governed by a strong upregulation of proinflammatory processes, which was downregulated at later time points after most of the fungal cells were killed. In stark contrast, we observed that the different fungal species pursued predominantly individual strategies and showed significantly different global transcriptome patterns. Among other findings, our functional analyses revealed that the fungal species relied on different metabolic pathways and virulence factors to survive the host-imposed stress. These data show that adaptation of Candida species as a response to the host is not a phylogenetic trait, but rather has likely evolved independently as a prerequisite to cause human infections.IMPORTANCE To ensure their survival, pathogens have to adapt immediately to new environments in their hosts, for example, during the transition from the gut to the bloodstream. Here, we investigated the basis of this adaptation in a group of fungal species which are among the most common causes of hospital-acquired infections, the Candida species. On the basis of a human whole-blood infection model, we studied which genes and processes are active over the course of an infection in both the host and four different Candida pathogens. Remarkably, we found that, while the human host response during the early phase of infection is predominantly uniform, the pathogens pursue largely individual strategies and each one regulates genes involved in largely disparate processes in the blood. Our results reveal that C. albicans, C. glabrata, C. parapsilosis, and C. tropicalis all have developed individual strategies for survival in the host. This indicates that their pathogenicity in humans has evolved several times independently and that genes which are central for survival in the host for one species may be irrelevant in another.

Authors: P. Kammer, S. McNamara, T. Wolf, T. Conrad, S. Allert, F. Gerwien, K. Hunniger, O. Kurzai, R. Guthke, B. Hube, J. Linde, S. Brunke