Bioprocess data analysis (data mining) Transcriptomics and proteomics data analysis and modelling Gene Regulatory Network inference (Reverse engineering) Decision making support systems in diagnostics, therapy and biotechnology
SEEK ID: https://funginet.hki-jena.de/people/2
Location:
Germany
ORCID: Not specified
Joined: 28th Sep 2012
Related items
- Programmes (1)
- Projects (6)
- Institutions (1)
- Investigations (0+4)
- Studies (0+4)
- Assays (0+5)
- Data files (3+2)
- Models (1+6)
- SOPs (1+3)
- Publications (32)
- Presentations (0+27)
- Events (1+11)
The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on ...
Projects: FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, A1, A2, A3, A4 (E), A5, B1, B2, B3 (E), B4, C1, C2, C3, C4 (E), C5, C6 (E), Z2, Z1, B5, A6, A7, A8, C7
Web page: http://www.funginet.de/home.html
Gastrointestinal colonisation and mechanisms of translocation of Candida albicans through gut mucosa
Predictive modelling of host-fungal pathogen interactions by reconstruction of gene regulatory networks
Creator: Reinhard Guthke
Submitter: Reinhard Guthke
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creator: Reinhard Guthke
Submitter: Reinhard Guthke
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creator: Reinhard Guthke
Submitter: Reinhard Guthke
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Primary hepatocytes were exposed to a stimulus by exchanging culture medium, thereby simulating changes in the blood composition. The expression of genes at different time points was recorded. Differentially expressed genes were clustered using fuzzy c-means algorithm into five groups. The arcs of the possible network were identified using the NetGenerator algorithm under the restriction of biological knowledge. The analysis was restricted to the main metabolic pathways of hepatocytes. The reverse ...
Creators: Thomas Wolf, Wolfgang Schmidt-Heck, Reinhard Guthke
Submitter: Thomas Wolf
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: JWS Online
Organism: Not specified
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
RNA-Seq is a method to measure the transcript/gene expression by adaption of High-throughput sequencing technologies. In contrast to microarrays where the measurement is based on a hybridization process, RNA-Seq sequences cDNA in order to get information about a sample's RNA content.
Creators: Reinhard Guthke, Jörg Linde, Steffen Priebe
Submitters: Reinhard Guthke, Sascha Schäuble
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Abstract (Expand)
Authors: P. Kammer, S. McNamara, T. Wolf, T. Conrad, S. Allert, F. Gerwien, K. Hunniger, O. Kurzai, R. Guthke, B. Hube, J. Linde, S. Brunke
Date Published: 6th Oct 2020
Publication Type: Not specified
PubMed ID: 33024045
Citation: mBio. 2020 Oct 6;11(5). pii: mBio.02435-20. doi: 10.1128/mBio.02435-20.
Abstract (Expand)
Authors: T. Conrad, O. Kniemeyer, S. G. Henkel, T. Kruger, D. J. Mattern, V. Valiante, R. Guthke, I. D. Jacobsen, A. A. Brakhage, S. Vlaic, J. Linde
Date Published: 20th Oct 2018
Publication Type: Not specified
PubMed ID: 30342519
Citation: BMC Syst Biol. 2018 Oct 20;12(1):88. doi: 10.1186/s12918-018-0620-8.
Abstract (Expand)
Authors: S. Vlaic, T. Conrad, C. Tokarski-Schnelle, M. Gustafsson, U. Dahmen, R. Guthke, S. Schuster
Date Published: 11th Jan 2018
Publication Type: Not specified
PubMed ID: 29323246
Citation: Sci Rep. 2018 Jan 11;8(1):433. doi: 10.1038/s41598-017-18370-2.
Abstract (Expand)
Authors: A. Dix, K. Czakai, I. Leonhardt, K. Schaferhoff, M. Bonin, R. Guthke, H. Einsele, O. Kurzai, J. Loffler, J. Linde
Date Published: 11th Mar 2017
Publication Type: Not specified
PubMed ID: 28280489
Citation: Front Microbiol. 2017 Feb 23;8:270. doi: 10.3389/fmicb.2017.00270. eCollection 2017.
Abstract (Expand)
Date Published: 27th Apr 2016
Publication Type: Not specified
PubMed ID: 27113568
Citation:
- September 2014
A5 und B1
Slevogt / Schuster
Start Date: 9th Sep 2014
End Date: Not specified
Event Website: Not specified
Country: Germany
City: Jena