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- Reinhard Guthke
Bioprocess data analysis (data mining)
Transcriptomics and proteomics data analysis and modelling
Gene Regulatory Network inference (Reverse engineering)
Decision making support systems in diagnostics, therapy and biotechnology
SEEK ID: https://funginet.hki-jena.de/people/2
Location:
Germany
Expertise: Integrative Data Analysis, Mathematical Modelling, Gene Regulatory Network Inference
ORCID: Not specified
FungiNet total (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)) ; FungiNet B - Bioinformatics projects (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)) ; FungiNet A - Aspergillus projects (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)) ; B3 (E) (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)) ; FungiNet C - Candida projects (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)) ; C5 (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI))
Related items
- Projects (6)
- Institutions (1)
- Investigations (0+4)
- Studies (0+4)
- Assays (0+5)
- Data files (3+2)
- Models (1+6)
- SOPs (1+3)
- Publications (32)
- Presentations (0+27)
- Events (1+11)
Gastrointestinal colonisation and mechanisms of translocation of Candida albicans through gut mucosa
Creator: Reinhard Guthke
Contributor: Reinhard Guthke
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creator: Reinhard Guthke
Contributor: Reinhard Guthke
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creator: Reinhard Guthke
Contributor: Reinhard Guthke
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Primary hepatocytes were exposed to a stimulus by exchanging culture medium, thereby simulating changes in the blood composition. The expression of genes at different time points was recorded. Differentially expressed genes were clustered using fuzzy c-means algorithm into five groups. The arcs of the possible network were identified using the NetGenerator algorithm under the restriction of biological knowledge. The analysis was restricted to the main metabolic pathways of hepatocytes. The reverse
...
Creators: Thomas Wolf, Wolfgang Schmidt-Heck, Reinhard Guthke
Contributor: Thomas Wolf
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: JWS Online
Organism: Not specified
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
RNA-Seq is a method to measure the transcript/gene expression by adaption of High-throughput sequencing technologies. In contrast to microarrays where the measurement is based on a hybridization process, RNA-Seq sequences cDNA in order to get information about a sample's RNA content.
Creators: Reinhard Guthke, Jörg Linde, Steffen Priebe
Contributors: Reinhard Guthke, Sascha Schäuble
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Abstract (Expand)
Authors: P. Kammer, S. McNamara, Thomas Wolf, Theresia Conrad, Stefanie Allert, F. Gerwien, Kerstin Hünniger, Oliver Kurzai, Reinhard Guthke, Bernhard Hube, Jörg Linde, S. Brunke
Date Published: 6th Oct 2020
Journal: mBio
PubMed ID: 33024045
Citation: mBio. 2020 Oct 6;11(5). pii: mBio.02435-20. doi: 10.1128/mBio.02435-20.
Abstract (Expand)
Authors: Theresia Conrad, Olaf Kniemeyer, S. G. Henkel, T. Kruger, D. J. Mattern, V. Valiante, Reinhard Guthke, Ilse Jacobsen, Axel Brakhage, S. Vlaic, Jörg Linde
Date Published: 20th Oct 2018
Journal: BMC Syst Biol
PubMed ID: 30342519
Citation: BMC Syst Biol. 2018 Oct 20;12(1):88. doi: 10.1186/s12918-018-0620-8.
Abstract (Expand)
Authors: S. Vlaic, Theresia Conrad, C. Tokarski-Schnelle, M. Gustafsson, U. Dahmen, Reinhard Guthke, Stefan Schuster
Date Published: 11th Jan 2018
Journal: Sci Rep
PubMed ID: 29323246
Citation: Sci Rep. 2018 Jan 11;8(1):433. doi: 10.1038/s41598-017-18370-2.
Abstract (Expand)
Authors: Andreas Dix, K. Czakai, I. Leonhardt, K. Schaferhoff, M. Bonin, Reinhard Guthke, Hermann Einsele, Oliver Kurzai, Jürgen Löffler, Jörg Linde
Date Published: 11th Mar 2017
Journal: Front Microbiol
PubMed ID: 28280489
Citation: Front Microbiol. 2017 Feb 23;8:270. doi: 10.3389/fmicb.2017.00270. eCollection 2017.
Abstract (Expand)
Authors: Andreas Dix, S. Vlaic, Reinhard Guthke, Jörg Linde
Date Published: 27th Apr 2016
Journal: Clin Microbiol Infect
PubMed ID: 27113568
Citation:
9. September 2014
A5 und B1
Slevogt / Schuster
Start Date: 9th Sep 2014
End Date: Not specified
Event Website: Not specified
Country: Germany
City: Jena