Philipp Brandt

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About Philipp Brandt:

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SEEK ID: https://funginet.hki-jena.de/people/143

Location: Germany

ORCID: Not specified

Joined: 1st Sep 2017

Expertise: Candida albicans

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Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on ...

Projects: FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, A1, A2, A3, A4 (E), A5, B1, B2, B3 (E), B4, C1, C2, C3, C4 (E), C5, C6 (E), Z2, Z1, B5, A6, A7, A8, C7

Web page: http://www.funginet.de/home.html

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FungiNet total

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Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/home.html

Organisms: Aspergillus fumigatus, Candida albicans

Regulation of Candida albicans virulence traits by protein kinases

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/project-c2.html

Organisms: Candida albicans

FungiNet C - Candida projects

No description specified

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/project-area-c.html

Organisms: Candida albicans

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Friedrich-Schiller-University

Country: Germany

City: 07745 Jena

Web page: Not specified

Showing 5 out of a possible 6 Publications Advanced Publications list for this Person with search and filtering

High-Throughput Profiling of Candida auris Isolates Reveals Clade-Specific Metabolic Differences.

INF, C2

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Candida auris, a multidrug-resistant human fungal pathogen that causes outbreaks of invasive infections, emerged as four distinct geographical clades. Previous studies identified genomic and proteomic … differences in nutrient utilization on comparison to Candida albicans, suggesting that certain metabolic features may contribute to C. auris emergence. Since no high-throughput clade-specific metabolic characterization has been described yet, we performed a phenotypic screening of C. auris strains from all 4 clades on 664 nutrients, 120 chemicals, and 24 stressors. We identified common and clade- or strain-specific responses, including the preferred utilization of various dipeptides as nitrogen source and the inability of the clade II isolate AR 0381 to withstand chemical stress. Further analysis of the metabolic properties of C. auris isolates showed robust growth on intermediates of the tricarboxylic acid cycle, such as citrate and succinic and malic acids. However, there was reduced or no growth on pyruvate, lactic acid, or acetate, likely due to the lack of the monocarboxylic acid transporter Jen1, which is conserved in most pathogenic Candida species. Comparison of C. auris and C. albicans transcriptomes of cells grown on alternative carbon sources and dipeptides as a nitrogen source revealed common as well as species-unique responses. C. auris induced a significant number of genes with no ortholog in C. albicans, e.g., genes similar to the nicotinic acid transporter TNA1 (alternative carbon sources) and to the oligopeptide transporter (OPT) family (dipeptides). Thus, C. auris possesses unique metabolic features which could have contributed to its emergence as a pathogen. IMPORTANCE Four main clades of the emerging, multidrug-resistant human pathogen Candida auris have been identified, and they differ in their susceptibilities to antifungals and disinfectants. Moreover, clade- and strain-specific metabolic differences have been identified, but a comprehensive overview of nutritional characteristics and resistance to various stressors is missing. Here, we performed high-throughput phenotypic characterization of C. auris on various nutrients, stressors, and chemicals and obtained transcriptomes of cells grown on selected nutrients. The generated data sets identified multiple clade- and strain-specific phenotypes and induction of C. auris-specific metabolic genes, showing unique metabolic properties. The presented work provides a large amount of information for further investigations that could explain the role of metabolism in emergence and pathogenicity of this multidrug-resistant fungus.

Authors: P. Brandt, M. H. Mirhakkak, L. Wagner, D. Driesch, A. Moslinger, P. Fander, S. Schauble, G. Panagiotou, S. Vylkova

Date Published: 15th Jun 2023

Publication Type: Journal

PubMed ID: 37097196

Citation: Microbiol Spectr. 2023 Jun 15;11(3):e0049823. doi: 10.1128/spectrum.00498-23. Epub 2023 Apr 25.

Created: 19th Jan 2024 at 12:10

Candida albicans SR-Like Protein Kinases Regulate Different Cellular Processes: Sky1 Is Involved in Control of Ion Homeostasis, While Sky2 Is Important for Dipeptide Utilization.

INF, C2, Z2, B5

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Protein kinases play a crucial role in regulating cellular processes such as growth, proliferation, environmental adaptation and stress responses. Serine-arginine (SR) protein kinases are highly conserved …

Authors: P. Brandt, F. Gerwien, L. Wagner, T. Kruger, B. Ramirez-Zavala, M. H. Mirhakkak, S. Schauble, O. Kniemeyer, G. Panagiotou, A. A. Brakhage, J. Morschhauser, S. Vylkova

Date Published: 23rd May 2022

Publication Type: Journal

PubMed ID: 35601106

Citation: Front Cell Infect Microbiol. 2022 May 6;12:850531. doi: 10.3389/fcimb.2022.850531. eCollection 2022.

Created: 19th Jan 2024 at 12:17

Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels.

INF, A5, C1, C2, B5

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Candida albicans is a leading cause of life-threatening hospital-acquired infections and can lead to Candidemia with sepsis-like symptoms and high mortality rates. We reconstructed a genome-scale C. …

Authors: M. H. Mirhakkak, S. Schauble, T. E. Klassert, S. Brunke, P. Brandt, D. Loos, R. V. Uribe, F. Senne de Oliveira Lino, Y. Ni, S. Vylkova, H. Slevogt, B. Hube, G. J. Weiss, M. O. A. Sommer, G. Panagiotou

Date Published: 15th Dec 2020

Publication Type: Not specified

PubMed ID: 33323978

Citation: ISME J. 2020 Dec 15. pii: 10.1038/s41396-020-00848-z. doi: 10.1038/s41396-020-00848-z.

Created: 9th Feb 2021 at 16:31, Last updated: 17th Jan 2024 at 10:24

Catch the wave: Metabolomic analyses in human pathogenic fungi.

Abstract

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Authors: P. Brandt, E. Garbe, S. Vylkova

Date Published: 21st Aug 2020

Publication Type: Not specified

PubMed ID: 32817633

Citation: PLoS Pathog. 2020 Aug 20;16(8):e1008757. doi: 10.1371/journal.ppat.1008757. eCollection 2020 Aug.

Created: 19th Feb 2021 at 08:24, Last updated: 17th Jan 2024 at 10:24

Clinical Candida albicans Vaginal Isolates and a Laboratory Strain Show Divergent Behaviors during Macrophage Interactions.

FungiNet C - Candida projects

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Typically, established lab strains are widely used to study host-pathogen interactions. However, to better reflect the infection process, the experimental use of clinical isolates has come more into …

Authors: F. Gerwien, C. Dunker, P. Brandt, E. Garbe, I. D. Jacobsen, S. Vylkova

Date Published: 19th Aug 2020

Publication Type: Not specified

PubMed ID: 32817377

Citation: mSphere. 2020 Aug 19;5(4). pii: 5/4/e00393-20. doi: 10.1128/mSphere.00393-20.

Created: 19th Feb 2021 at 08:23, Last updated: 17th Jan 2024 at 10:24

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