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Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"
The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on these microorganisms therefore will discover and elucidate novel biological principles, including new regulatory and metabolic pathways.
To obtain a comprehensive insight into these medically important fungi, scientists from Jena and Würzburg have initiated the Collaborative Research Center / Transregio 124 Pathogenic fungi and their human host: Networks of Interaction - FungiNet.
The aims of this CRC/Transregio are
(1) to identify pathogenic determinants specific for each fungus,
(2) to investigate the specific roles of epithelial barriers, the mechanisms of the innate immunity and potential contributions of the adaptive immune system for/to the pathogenesis of fungal infections,
(3) to elucidate the complex mechanisms of fungal infections and identify common principles of fungal pathogenesis and
(4) to use this information for new therapeutic approaches.
For a comprehensive description and understanding of complex invasive fungal infections, we believe it is important to apply a systems biological approach as a third dimension added to the pathobiology of the pathogens and the response of the immune system. Systems biology will contribute to uncover the structure and dynamics of molecular and cellular cause-effect relations within these pathogenic interactions.
FungiNet applies three interlinked approaches to fungal pathogenesis:
A Aspergillus fumigatus: from environmental microorganism to pathogen
B Bioinformatics / Computational systems biology of infection: creation of a “virtual infection model”
C Candida albicans: from commensal to pathogen
Web page: http://www.funginet.de/home.html
Funding details:DFG
Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"
Related items
- People (129)
- Projects (27)
- Institutions (23)
- Investigations (16+41)
- Studies (45+39)
- Assays (46+50)
- Data files (67+80)
- Models (11+12)
- SOPs (7+24)
- Publications (194)
- Presentations (12+239)
- Events (5+56)
- Documents (0+3)
Projects: A4 (E)
Institutions: Julius Maximilians University Würzburg, Department of Internal Medicine II
Institutions: BioControl Jena GmbH
Projects: A3
Institutions: Julius Maximilians University Würzburg, Department of Internal Medicine II
Ionic regulation of Th17-mediated immune responses to Candida infection
Gene-engineered CAR T-cells and macrophages to treat Aspergillus fumigatus infection
P Hortschansky, M Eisendle, Q Al-Abdallah, A D Schmidt, S Bergmann, M Thön, O Kniemeyer, B Abt, B Seeber, E R Werner, M Kato, A A Brakhage and H Haas. Interaction of HapX with the CCAAT-binding complex-a novel mechanism of gene regulation by iron. EMBO J. 2007 Jul 11;26(13):3157-68. Epub 2007 Jun 14
Wartenberg D, Vödisch M, Kniemeyer O, Albrecht-Eckardt D, Scherlach K, Winkler R, Weide M, Brakhage AA. Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans-The role of a putative dehydrin. J Proteomics. 2012 May 23.
Snapshots: No snapshots
Studies: Control, Farnesol Treatment, Internal Standard
Assays: Control gels, Farnesol gels, Standard gels
D Albrecht, R Guthke, A A Brakhage, O Kniemeyer. Integrative analysis of the heat shock response in Aspergillus fumigatus. BMC Genomics. 2010 Jan 15;11:32.
Find corresponding transcriptomic data at ArrayExpress: E-MEXP-332
Snapshots: No snapshots
Dirk Wartenberg, Katrin Lapp, Ilse D. Jacobsen, Hans-Martin Dahse, Olaf Kniemeyer, Thorsten Heinekamp, Axel A. Brakhage
Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knoell-Institute (HKI), Jena, Germany. Secretome analysis of Aspergillus fumigatus reveals Asp-hemolysin as a major secreted protein. Int J Med Microbiol. 2011, Nov;301(7):602-11
Snapshots: No snapshots
Studies: Mastermap
Assays: Mastermap Secretome
Teutschbein J, Simon S, Lother J, Springer J, Hortschansky P, Morton CO, Löffler J, Einsele H, Conneally E, Rogers TR, Guthke R, Brakhage AA, Kniemeyer O. Proteomic profiling of serological responses to Aspergillus fumigatus antigens in patients with invasive aspergillosis. J Proteome Res 2016 Mar 24
Snapshots: No snapshots
Studies: YPD
Assays: Vergleichsgel
Person responsible: Daniela Albrecht-Eckardt
Snapshots: No snapshots
Investigation: Gene regulation by hapX
Assays: deltaHapX
Person responsible: Daniela Albrecht-Eckardt
Snapshots: No snapshots
Investigation: Gene regulation by hapX
Assays: wt
.
Person responsible: Daniela Albrecht-Eckardt
Snapshots: No snapshots
Investigation: Farnesol
Assays: Standard gels
Aspergillus nidulans R21 was grown over night in AMM at 37°C and 200 rpm. The culture was treated with 50 µM farnesol or the same volume of ethanol without farnesol as control. The culture was harvested after 3 hours of further incubation.
Person responsible: Daniela Albrecht-Eckardt
Snapshots: No snapshots
Investigation: Farnesol
Assays: Farnesol gels
Person responsible: Daniela Albrecht-Eckardt
Snapshots: No snapshots
Investigation: Farnesol
Assays: Control gels
Contributor: Daniela Albrecht-Eckardt
Assay type: Experimental Assay Type
Technology type: Technology Type
Snapshots: No snapshots
Investigation: Biofilm formation over time
Study: Transcriptome
Organisms: No organisms
SOPs: No SOPs
Data files: 48h_data
Contributor: Daniela Albrecht-Eckardt
Assay type: Experimental Assay Type
Technology type: Technology Type
Snapshots: No snapshots
Investigation: Gene regulation by hapX
Study: deltaHapX
Organisms: No organisms
SOPs: No SOPs
Data files: deltaHapX data
Contributor: Daniela Albrecht-Eckardt
Assay type: Experimental Assay Type
Technology type: Technology Type
Snapshots: No snapshots
Investigation: Gene regulation by hapX
Study: wt
Organisms: No organisms
SOPs: No SOPs
Data files: wt data
Contributor: Daniela Albrecht-Eckardt
Assay type: Experimental Assay Type
Technology type: Technology Type
Snapshots: No snapshots
Investigation: Farnesol
Study: Internal Standard
Organisms: No organisms
SOPs: No SOPs
Data files: Standard data
Contributor: Daniela Albrecht-Eckardt
Assay type: Experimental Assay Type
Technology type: Technology Type
Snapshots: No snapshots
Investigation: Farnesol
Study: Farnesol Treatment
Organisms: No organisms
SOPs: No SOPs
Data files: Farnesol data
README
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This package contains code that generates and analyses tracks in 2D given three
distinct condition; non-persistent, persistent and directed by the
Ornstein-Uhlenbeck process. Full details on the analysis can be found in the
article "Svensson et al., Untangling cell tracks: quantifying cell migration by
time lapse image data analysis, Cytometry Pt A, 2017". The paper can be found
on
...
Creator: Carl-Magnus Svensson
Contributor: Carl-Magnus Svensson
Model type: Ordinary differential equations (ODE)
Model format: Not specified
Environment: Not specified
Organism: Not specified
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
This model is a variant of the previously developed SBM of whole-blood infection assay. While in the previous model a spontaneous immune evasion mechanism (A) was implemented in this model immune evasion was caused by PMN molecule secretion (B).
Creators: Teresa Lehnert, Maria T. E. Prauße
Contributor: Sandra Timme
Model type: Not specified
Model format: Not specified
Environment: Not specified
Organism: Candida albicans
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
The state-based model (SBM) allow to simulate the interplay between innate immune cells, such as monocytes and PMN, and Candida albicans and to quantify immune reaction rates like phagocytosis and killing rates. It is implemented in C++.
Creator: Teresa Lehnert
Contributor: Sandra Timme
Model type: Not specified
Model format: Not specified
Environment: Not specified
Organism: Candida albicans
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
DynaCoSys models the complement system by using a combination of Ordinary and Partial Differential Equations.
Creators: Teresa Lehnert, Alexander Tille
Contributor: Sandra Timme
Model type: Partial differential equations (PDE)
Model format: Not specified
Environment: Not specified
Organism: Candida albicans
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
Adaptation of the previously developed virtual infection model of Aspergillus fumigatus in a *human* alveolus.
This model comprises a hybrid agent-based model of a single murine alveolus. The alveolus is represented in a realistic to-scale representation and contains the cell types of alveolar epithelial cells (AEC) of type 1 and 2 as well as the pores of Kohn (PoK).
Furthermore, in this model, depending on the infection dose multiple A. fumigatus conidium are inserted into the alveolus and the
...
Creators: Sandra Timme, Marco Blickensdorf
Contributor: Sandra Timme
Model type: Agent based modelling
Model format: Not specified
Environment: Not specified
Organism: Aspergillus fumigatus
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
RNA-Seq is a method to measure the transcript/gene expression by adaption of High-throughput sequencing technologies. In contrast to microarrays where the measurement is based on a hybridization process, RNA-Seq sequences cDNA in order to get information about a sample's RNA content.
Creators: Reinhard Guthke, Jörg Linde, Steffen Priebe
Contributors: Reinhard Guthke, Sascha Schäuble
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creator: Franziska Hoffmann
Contributor: Franziska Hoffmann
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creator: Franziska Hoffmann
Contributor: Franziska Hoffmann
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creators: Franziska Hoffmann, Daniela Pelzel
Contributor: Franziska Hoffmann
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creators: Franziska Hoffmann, Daniela Pelzel
Contributor: Franziska Hoffmann
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Abstract (Expand)
Authors: B. Hebecker, S. Vlaic, T. Conrad, Michael Bauer, S. Brunke, M. Kapitan, Jörg Linde, B. Hube, Ilse Jacobsen
Date Published: No date defined
Journal: Sci Rep
PubMed ID: 27808111
Citation: Sci Rep. 2016 Nov 3;6:36055. doi: 10.1038/srep36055.
Abstract (Expand)
Authors: M. Tscherner, F. Zwolanek, S. Jenull, F. J. Sedlazeck, A. Petryshyn, I. E. Frohner, J. Mavrianos, N. Chauhan, A. von Haeseler, K. Kuchler
Date Published: No date defined
Journal: PLoS Pathog
PubMed ID: 26473952
Citation: PLoS Pathog. 2015 Oct 16;11(10):e1005218. doi: 10.1371/journal.ppat.1005218. eCollection 2015 Oct.
Abstract (Expand)
Authors: P. Vandeputte, S. Pradervand, F. Ischer, A. T. Coste, S. Ferrari, K. Harshman, D. Sanglard
Date Published: No date defined
Journal: Eukaryot Cell
PubMed ID: 22581526
Citation: Eukaryot Cell. 2012 Jul;11(7):916-31. doi: 10.1128/EC.00134-12. Epub 2012 May 11.
Abstract (Expand)
Authors: None
Date Published: No date defined
Journal: Cellular Microbiology
PubMed ID: 27552083
DOI: 10.1111/cmi.12657
Citation: Förster, T. M., Mogavero, S., Dräger, A., Graf, K., Polke, M., Jacobsen, I. D., and Hube, B. (2016), Enemies and brothers in arms: Candida albicans and gram?positive bacteria, Cellular Microbiology, doi: 10.1111/cmi.12657
Abstract (Expand)
Authors: V. Voltersen, M. G. Blango, S. Herrmann, F. Schmidt, Thorsten Heinekamp, M. Strassburger, Thomas Krüger, P. Bacher, Jasmin Lother, Esther Weiß, Kerstin Hünniger, H. Liu, P. Hortschansky, A. Scheffold, Jürgen Löffler, S. Krappmann, S. Nietzsche, Oliver Kurzai, Hermann Einsele, Olaf Kniemeyer, S. G. Filler, U. Reichard, Axel Brakhage
Date Published: No date defined
Journal: MBio
PubMed ID: 30279286
Citation: MBio. 2018 Oct 2;9(5). pii: mBio.01557-18. doi: 10.1128/mBio.01557-18.
Start Date: 19th Nov 2018
End Date: 20th Nov 2018
Event Website: Not specified
Country: Germany
City: Bad Staffelstein
This year's 12th IMIHM meeting is held for the fifth time as a Joint Meeting together with scientists from the CRC TransRegio 124 (“Pathogenic fungi and their human host: Networks of interaction – FungiNet”). This collaborative Research Centre FungiNet is a network of scientists from Jena and Wuerzburg and is funded by the Deutsche Forschungsgemeinschaft. The Consortium collaborates to better understand complex invasive mycoses by investigating the pathobiology of fungi, the response of the immune
...
Start Date: 26th Jun 2018
End Date: 27th Jun 2018
Event Website: Not specified
Country: Germany
City: Würzburg
This year‘s 11 th IMIHM meeting is held for the fourth time as a Joint Meeting together with scientists from the CRC TransRegio 124 (“Pathogenic fungi and their human host: Networks of interaction – FungiNet”). This Collaborative Research Centre FungiNet is a network of scientists from Jena and Wuerzburg and is funded by the Deutsche Forschungsgemeinschaft. The Consortium collaborates to better understand complex invasive mycoses by investigating the pathobiology of fungi, the response of the
...
Start Date: 7th Sep 2017
End Date: 8th Sep 2017
Event Website: Not specified
Country: Germany
City: Würzburg
Start Date: 9th Feb 2017
End Date: 10th Feb 2017
Event Website: Not specified
Country: Germany
City: Würzburg
9. September 2014
A5 und B1
Slevogt / Schuster
Start Date: 9th Sep 2014
End Date: Not specified
Event Website: Not specified
Country: Germany
City: Jena