State-based model of whole-blood infection assay with PMN-mediated immune evasion mechanism

Version 1

The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on ...

Image data analysis and agent-based modelling of the spatio-temporal interaction between immune cells and human-pathogenic fungi