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Strain details
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Related items
Gene-engineered CAR T-cells and macrophages to treat Aspergillus fumigatus infection
Role and targeting of bioactive lipid mediators in Aspergillus fumigatus innate immune cell interactions
Public web page: Not specified
Organisms: Aspergillus fumigatus
Adaptation of the previously developed virtual infection model of Aspergillus fumigatus in a *human* alveolus.
This model comprises a hybrid agent-based model of a single murine alveolus. The alveolus is represented in a realistic to-scale representation and contains the cell types of alveolar epithelial cells (AEC) of type 1 and 2 as well as the pores of Kohn (PoK).
Furthermore, in this model, depending on the infection dose multiple A. fumigatus conidium are inserted into the alveolus and the
...
Creators: Sandra Timme, Marco Blickensdorf
Contributor: Sandra Timme
Model type: Agent based modelling
Model format: Not specified
Environment: Not specified
Organism: Aspergillus fumigatus
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
This model comprises a hybrid agent-based model of a single human alveolus. The alveolus is represented in a realistic to-scale representation and contains the cell types of alveolar epithelial cells (AEC) of type 1 and 2 as well as the pores of Kohn (PoK). A single A. fumigatus conidium in inserted into the alveolus and the AEC, where the conidium is located secretes chemokines. Chemokine secretion is modelled using the partial differential equation of the diffusion equation and numerically
...
Creator: Johannes Pollmächer
Contributor: Sandra Timme
Model type: Agent based modelling
Model format: Not specified
Environment: Not specified
Organism: Aspergillus fumigatus
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
This is the image analysis algorithm used in Cseresnyes, Kraibooj and Figge, Hessian-based quantitative image analysis of host-pathogen confrontation assays
Cytometry A. 2018 Mar;93(3):346-356. doi: 10.1002/cyto.a.23201. Code is being maintained at https://github.com/applied-systems-biology/ACAQ3.
Read.me
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This package contains code that implements the Hessian-based macrophage segmentation algorithm.
In addition, the
...
Creator: Carl-Magnus Svensson
Contributor: Carl-Magnus Svensson
Model type: Not specified
Model format: Not specified
Environment: Not specified
Organism: Aspergillus fumigatus
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
Abstract (Expand)
Authors: M. Blickensdorf, Sandra Timme, Marc Thilo Figge
Date Published: 27th Feb 2019
Journal: Front Immunol
PubMed ID: 30804941
Citation: Front Immunol. 2019 Feb 5;10:142. doi: 10.3389/fimmu.2019.00142. eCollection 2019.
Abstract (Expand)
Authors: Z. Cseresnyes, Kaswara Kraibooj, Marc Thilo Figge
Date Published: 16th Sep 2017
Journal: Cytometry A
PubMed ID: 28914994
Citation: Cytometry A. 2018 Mar;93(3):346-356. doi: 10.1002/cyto.a.23201. Epub 2017 Sep 15.
Abstract (Expand)
Authors: J. Pollmacher, Sandra Timme, Stefan Schuster, Axel Brakhage, Peter Zipfel, Marc Thilo Figge
Date Published: 13th Jun 2016
Journal: Sci Rep
PubMed ID: 27291424
Citation: Sci Rep. 2016 Jun 13;6:27807. doi: 10.1038/srep27807.
Abstract (Expand)
Authors: H. Irmer, S. Tarazona, C. Sasse, P. Olbermann, J. Loeffler, S. Krappmann, A. Conesa, G. H. Braus
Date Published: 28th Aug 2015
Journal: BMC Genomics
PubMed ID: 26311470
Citation: BMC Genomics. 2015 Aug 27;16:640. doi: 10.1186/s12864-015-1853-1.
Abstract (Expand)
Authors: J. Pollmacher, Marc Thilo Figge
Date Published: 16th Jun 2015
Journal: Front Microbiol
PubMed ID: 26074897
Citation: Front Microbiol. 2015 May 28;6:503. doi: 10.3389/fmicb.2015.00503. eCollection 2015.