Publications

Abstract (Expand)

Understanding optimality principles shaping the evolution of regulatory networks controlling metabolism is crucial for deriving a holistic picture of how metabolism is integrated into key cellular ...

Authors: Jan Ewald, Christoph Kaleta, Bartl M.

Date Published: 30th Jul 2017

Journal: Biochem Soc Trans

Abstract (Expand)

Candida albicans colonizes human mucosa, including the gastrointestinal tract, as a commensal. In immunocompromised patients, C. albicans can breach the intestinal epithelial barrier and cause fatal ...

Author: Klaile E.,Muller M. M.,Schafer M. R.,Clauder A. K.,Feer S.,Heyl K. A.,Stock M.,Klassert T. E.,Zipfel P. F.,Singer B. B.,Slevogt H.

Date Published: 16th Mar 2017

Journal: MBio

Abstract (Expand)

A precise and rapid adjustment of fluxes through metabolic pathways is crucial for organisms to prevail in changing environmental conditions. Based on this reasoning, many guiding principles that govern ...

Authors: Jan Ewald, Thomas Dandekar, Christoph Kaleta, Bartl M.

Date Published: 18th Feb 2017

Journal: PLoS Comput Biol

Abstract (Expand)

Helicobacter pylori specifically colonizes the human gastric epithelium and is the major causative agent for ulcer disease and gastric cancer development. Here, we identify members of the carcinoembryonic ...

Authors: Esther Klaile, Hortense Slevogt, Javaheri A.,Kruse T.,Moonens K.,Mejias-Luque R.,Debraekeleer A.,Asche C. I.,Tegtmeyer N.,Kalali B.,Bach N. C.,Sieber S. A.,Hill D. J.,Koniger V.,Hauck C. R.,Moskalenko R.,Haas R.,Busch D. H.,Schmidt A.,Backert S.,Remaut H.,Singer B. B.,Gerhard M.

Date Published: 18th Oct 2016

Journal: Nat Microbiol

Abstract (Expand)

Mushrooms, such as Schizophyllum commune, have a specific odor. Whether this is linked to mating, prerequisite for mushroom formation, or also found in monokaryotic, unmated strains, was investigated ...

Authors: Olaf Kniemeyer, Jörg Linde, Freihorst D.,Brunsch M.,Wirth S.,Krause K.,Kunert M.,Boland W.,Kothe E.

Date Published: 7th Sep 2016

Journal: Fungal Genet Biol

Abstract (Expand)

Humans are continuously exposed to airborne spores of the saprophytic fungus Aspergillus fumigatus. However, in healthy individuals pulmonary host defense mechanisms efficiently eliminate the fungus. ...

Authors: Natarajaswamy Kalleda, Hermann Einsele, Matthias Brock, Katrin Heinze, Andreas Beilhack, Amich J.,Arslan B.,Poreddy S.,Mattenheimer K.,Mokhtari Z.

Date Published: 13th Jul 2016

Journal: Front Microbiol

Abstract (Expand)

Invasive fungal infections are associated with high mortality rates and are mostly caused by the opportunistic fungi Aspergillus fumigatus and Candida albicans. Immune responses against these fungi are ...

Authors: Andreas Dix, Jörg Linde, Hermann Einsele, Oliver Kurzai, Jürgen Löffler, Czakai K.,Leonhardt I.,Bonin M.

Date Published: 28th Jun 2016

Journal: Sci Rep

Abstract (Expand)

As part of the innate immune system, natural killer (NK) cells are directly involved in the response to fungal infections. Perforin has been identified as the major effector molecule acting against ...

Authors: Dragana Slavkovic Lukic, Jürgen Löffler, Daniela Albrecht-Eckardt, Michael Weber, Stefanie Allert, Oliver Kurzai, Kerstin Hünniger, Voigt J.,Bouzani M.,Martin R.

Date Published: 19th May 2016

Journal: Front Microbiol

Abstract (Expand)

In systems biology, researchers aim to understand complex biological systems as a whole, which is often achieved by mathematical modelling and the analyses of high-throughput data. In this review, we ...

Authors: Andreas Dix, Reinhard Guthke, Jörg Linde, Vlaic S.

Date Published: 27th Apr 2016

Journal: Clin Microbiol Infect

Abstract (Expand)

In the emerging field of systems biology of fungal infection, one of the central roles belongs to the modeling of gene regulatory networks (GRNs). Utilizing omics-data, GRNs can be predicted by ...

Authors: Reinhard Guthke, Theresia Conrad, Ekaterina Shelest, Jörg Linde, Gerber S.,Vlaic S.,Durmus S.,Cakir T.,Sevilgen F. E.

Date Published: 22nd Apr 2016

Journal: Front Microbiol

Abstract (Expand)

The human restricted pathogen Moraxella catarrhalis is an important causal agent for exacerbations in chronic obstructive lung disease (COPD) in adults. In such patients, increased numbers of granulocytes ...

Authors: Tobias Müller, Tilman Klassert, Hortense Slevogt, Heinrich A.,Heyl K. A.,Klaile E.,Wiessner A.,Fischer K.,Schumann R. R.,Seifert U.,Riesbeck K.,Moter A.,Singer B. B.,Bachmann S.

Date Published: 3rd Apr 2016

Journal: Cell Microbiol

Abstract (Expand)

Organisms constantly interact with other species through physical contact which leads to changes on the molecular level, for example the transcriptome. These changes can be monitored for all genes, ...

Authors: Sylvie Schulze, Reinhard Guthke, Jörg Linde, Schleicher J.

Date Published: 31st Mar 2016

Journal: Front Microbiol

Abstract (Expand)

Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate or modulate host immune responses. ...

Authors: Toni Förster, Lydia Kasper, Oliver Kurzai, Bernhard Hube, Moyes D. L.,Wilson D.,Richardson J. P.,Mogavero S.,Tang S. X.,Wernecke J.,Hofs S.,Gratacap R. L.,Robbins J.,Runglall M.,Murciano C.,Blagojevic M.,Thavaraj S.,Hebecker B.,Vizcay G.,Iancu S. I.,Kichik N.,Hader A.,Luo T.,Kruger T.,Kniemeyer O.,Cota E.,Bader O.,Wheeler R. T.,Gutsmann T.,Naglik J. R.

Date Published: 30th Mar 2016

Journal: Nature

Abstract (Expand)

Invasive aspergillosis (IA) is a devastating opportunistic infection and its treatment constitutes a considerable burden for the health care system. Immunocompromised patients are at an increased risk ...

Authors: Andreas Dix, Reinhard Guthke, Hermann Einsele, Jörg Linde, Jürgen Löffler, Czakai K.,Springer J.,Fliesser M.,Bonin M.,Schmitt A. L.

Date Published: 21st Mar 2016

Journal: Front Microbiol

Abstract (Expand)

Aspergillus fumigatus is the predominant airborne pathogenic fungus causing invasive aspergillosis in immunocompromised patients. During infection A. fumigatus has to adapt to oxygen-limiting conditions ...

Authors: Ilse Jacobsen, Ekaterina Shelest, Axel Brakhage, Olaf Kniemeyer, Kroll K.,Shekhova E.,Mattern D. J.,Thywissen A.,Strassburger M.,Heinekamp T.

Date Published: 19th Mar 2016

Journal: Mol Microbiol

Abstract (Expand)

Aspergillus fumigatus is the species that most commonly causes the opportunistic infection invasive aspergillosis (IA) in patients being treated for hematological malignancies. Little is known about ...

Authors: Jürgen Löffler, Hermann Einsele, Reinhard Guthke, Axel Brakhage, Olaf Kniemeyer, Teutschbein J.,Simon S.,Lother J.,Springer J.,Hortschansky P.,Morton C. O.,Conneally E.,Rogers T. R.

Date Published: 15th Mar 2016

Journal: J Proteome Res

Abstract (Expand)

Here, we report the draft genome sequence of Aspergillus calidoustus (strain SF006504). The functional annotation of A. calidoustus predicts a relatively large number of secondary metabolite gene ...

Authors: Jörg Linde, Reinhard Guthke, Axel Brakhage, Vito Valiante, Horn F.,Mattern D. J.,Walther G.,Scherlach K.,Martin K.,Petzke L.

Date Published: 12th Mar 2016

Journal: Genome Announc

Abstract (Expand)

Recent and rapidly evolving progress on high-throughput measurement techniques and computational performance has led to the emergence of new disciplines, such as systems medicine and translational ...

Authors: Theresia Conrad, Reinhard Guthke, Jörg Linde, Schleicher J.,Gustafsson M.,Cedersund G.

Date Published: 10th Feb 2016

Journal: Brief Funct Genomics

Abstract:

Not specified

Authors: Reinhard Guthke, Durmus S.,Cakir T.

Date Published: 4th Feb 2016

Journal: Front Microbiol

Abstract (Expand)

Intestinal epithelial cells (IEC) form a tight barrier to the gut lumen. Paracellular permeability of the intestinal barrier is regulated by tight junction proteins and can be modulated by microorganisms ...

Authors: Sylvie Schulze, Daniela Albrecht-Eckardt, Kerstin Hünniger, Jörg Linde, Reinhard Guthke, Oliver Kurzai, Bohringer M.,Pohlers S.,Piegsa J.,Weber M.,Martin R.

Date Published: 12th Jan 2016

Journal: Cell Microbiol

Abstract (Expand)

Mitogen activated protein kinases (MAPKs) are highly conserved in eukaryotic organisms. In pathogenic fungi, their activities were assigned to different physiological functions including drug adaptation ...

Authors: Reinhard Guthke, Axel Brakhage, Jörg Linde, Altwasser R.,Baldin C.,Weber J.,Kniemeyer O.,Valiante V.

Date Published: 10th Sep 2015

Journal: PLoS One

Abstract (Expand)

UNLABELLED: Single-celled organisms have different strategies to sense and utilize nutrients in their ever-changing environments. The opportunistic fungal pathogen Candida albicans is a common member ...

Author: Du H.,Guan G.,Li X.,Gulati M.,Tao L.,Cao C.,Johnson A. D.,Nobile C. J.,Huang G.

Date Published: 10th Sep 2015

Journal: MBio

Abstract (Expand)

As a successful commensal and pathogen of humans, Candida albicans encounters a wide range of environmental conditions. Among them, ambient pH, which changes frequently and affects many biological ...

Author: Sun Y.,Cao C.,Jia W.,Tao L.,Guan G.,Huang G.

Date Published: 6th Sep 2015

Journal: Eukaryot Cell

Abstract (Expand)

Candida albicans is associated with humans as both a harmless commensal organism and a pathogen. Cph2 is a transcription factor whose DNA binding domain is similar to that of mammalian sterol response ...

Author: Lane S.,Di Lena P.,Tormanen K.,Baldi P.,Liu H.

Date Published: 6th Sep 2015

Journal: Eukaryot Cell

Abstract (Expand)

The genus Penicillium belongs to the phylum Ascomycota and includes a variety of fungal species important for food and drug production. We report the draft genome sequence of Penicillium brasilianum ...

Authors: Jörg Linde, Reinhard Guthke, Axel Brakhage, Horn F.,Mattern D. J.,Walther G.,Valiante V.

Date Published: 5th Sep 2015

Journal: Genome Announc

Abstract (Expand)

BACKGROUND: Invasive aspergillosis is started after germination of Aspergillus fumigatus conidia that are inhaled by susceptible individuals. Fungal hyphae can grow in the lung through the epithelial ...

Author: Irmer H.,Tarazona S.,Sasse C.,Olbermann P.,Loeffler J.,Krappmann S.,Conesa A.,Braus G. H.

Date Published: 28th Aug 2015

Journal: BMC Genomics

Abstract (Expand)

More than 80 years after its discovery, penicillin is still a widely used and commercially highly important antibiotic. Here, we analyse the metabolic network of penicillin synthesis in Penicillium ...

Authors: Reinhard Guthke, Stefan Schuster, Prausse M. T.,Schauble S.

Date Published: 19th Aug 2015

Journal: Biotechnol Bioeng

Abstract (Expand)

Fungal microorganisms frequently lead to life-threatening infections. Within this group of pathogens, the commensal Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most ...

Authors: Christian Remmele, Thomas Dandekar, Tobias Müller, Marcus Dittrich, Luther C. H.,Balkenhol J.

Date Published: 4th Aug 2015

Journal: Front Microbiol

Abstract (Expand)

The diploid, polymorphic yeast Candida albicans is one of the most important human pathogenic fungi. C. albicans can grow, proliferate and coexist as a commensal on or within the human host for a long ...

Authors: Sybille Dühring, Christine Skerka, Peter Zipfel, Thomas Dandekar, Stefan Schuster, Germerodt S.

Date Published: 30th Jun 2015

Journal: Front Microbiol

Abstract (Expand)

Opportunistic fungal pathogens can cause bloodstream infection and severe sepsis upon entering the blood stream of the host. The early immune response in human blood comprises the elimination of pathogens ...

Authors: Sandra Timme, Kerstin Hünniger, Oliver Kurzai, Marc Thilo Figge, Lehnert T.,Pollmacher J.

Date Published: 19th Jun 2015

Journal: Front Microbiol

Abstract (Expand)

Studying the pathobiology of the fungus Aspergillus fumigatus has gained a lot of attention in recent years. This is due to the fact that this fungus is a human pathogen that can cause severe diseases, ...

Authors: Hanno Schoeler, Axel Brakhage, Marc Thilo Figge, Kraibooj K.,Svensson C. M.

Date Published: 9th Jun 2015

Journal: Front Microbiol

Abstract (Expand)

Fungal infections have increased dramatically in the last 2 decades, and fighting infectious diseases requires innovative approaches such as the combination of two drugs acting on different targets or ...

Authors: Vito Valiante, Olaf Kniemeyer, Axel Brakhage, Monteiro M. C.,Martin J.,Altwasser R.,El Aouad N.,Gonzalez I.,Mellado E.,Palomo S.,de Pedro N.,Perez-Victoria I.,Tormo J. R.,Vicente F.,Reyes F.,Genilloud O.

Date Published: 8th Jun 2015

Journal: Antimicrob Agents Chemother

Abstract (Expand)

The Tor (target of rapamycin) kinase is one of the major regulatory nodes in eukaryotes. Here, we analyzed the Tor kinase in Aspergillus fumigatus, which is the most important airborne fungal pathogen ...

Authors: Axel Brakhage, Baldin C.,Valiante V.,Kruger T.,Schafferer L.,Haas H.,Kniemeyer O.

Date Published: 26th May 2015

Journal: Proteomics

Abstract (Expand)

BACKGROUND: Adjusting the capacity of metabolic pathways in response to rapidly changing environmental conditions is an important component of microbial adaptation strategies to stochastic environments. ...

Authors: Christoph Kaleta, de Hijas-Liste G. M.,Balsa-Canto E.,Ewald J.,Bartl M.,Li P.,Banga J. R.

Date Published: 16th May 2015

Journal: BMC Bioinformatics

Abstract (Expand)

BACKGROUND: Adjusting the capacity of metabolic pathways in response to rapidly changing environmental conditions is an important component of microbial adaptation strategies to stochastic environments. ...

Authors: Jan Ewald, Christoph Kaleta, de Hijas-Liste G. M.,Balsa-Canto E.,Bartl M.,Li P.,Banga J. R.

Date Published: 16th May 2015

Journal: BMC Bioinformatics

Abstract (Expand)

Candida albicans and Candida glabrata account for the majority of candidiasis cases worldwide. Although both species are in the same genus, they differ in key virulence attributes. Within this work, ...

Authors: Kerstin Hünniger, Michael Bauer, Ilse Jacobsen, Marc Thilo Figge, Oliver Kurzai, Duggan S.,Essig F.,Mokhtari Z.,Lehnert T.,Brandes S.,Hader A.,Martin R.

Date Published: 5th May 2015

Journal: Cell Microbiol

Abstract (Expand)

In this work, we investigate optimality principles behind synthesis strategies for protein complexes using a dynamic optimization approach. We show that the cellular capacity of protein synthesis has ...

Authors: Christoph Kaleta, Ewald J.,Kotzing M.,Bartl M.

Date Published: 1st May 2015

Journal: Metabolites

Abstract (Expand)

In this work, we investigate optimality principles behind synthesis strategies for protein complexes using a dynamic optimization approach. We show that the cellular capacity of protein synthesis has ...

Authors: Jan Ewald, Christoph Kaleta, Kotzing M.,Bartl M.

Date Published: 1st May 2015

Journal: Metabolites

Abstract (Expand)

Pathogens manipulate the cellular mechanisms of host organisms via pathogen-host interactions (PHIs) in order to take advantage of the capabilities of host cells, leading to infections. The crucial ...

Authors: Reinhard Guthke, Durmus S.,Cakir T.,Ozgur A.

Date Published: 9th Apr 2015

Journal: Front Microbiol

Abstract (Expand)

Farnesol, produced by the polymorphic fungus Candida albicans, is the first quorum-sensing molecule discovered in eukaryotes. Its main function is control of C. albicans filamentation, a process closely ...

Authors: Kerstin Hünniger, Oliver Kurzai, Leonhardt I.,Spielberg S.,Weber M.,Albrecht-Eckardt D.,Blass M.,Claus R.,Barz D.,Scherlach K.,Hertweck C.,Loffler J.

Date Published: 19th Mar 2015

Journal: MBio

Abstract (Expand)

Candida albicans is a major cause of bloodstream infection which may present as sepsis and septic shock - major causes of morbidity and mortality world-wide. After invasion of the pathogen, innate ...

Authors: Kerstin Hünniger, Oliver Kurzai, Duggan S.,Leonhardt I.

Date Published: 18th Mar 2015

Journal: Virulence

Abstract (Expand)

Sepsis is a clinical syndrome that can be caused by bacteria or fungi. Early knowledge on the nature of the causative agent is a prerequisite for targeted anti-microbial therapy. Besides currently used ...

Authors: Andreas Dix, Kerstin Hünniger, Reinhard Guthke, Oliver Kurzai, Jörg Linde, Weber M.

Date Published: 11th Mar 2015

Journal: Front Microbiol

Abstract (Expand)

Gene regulatory network inference is a systems biology approach which predicts interactions between genes with the help of high-throughput data. In this review, we present current and updated network ...

Authors: Jörg Linde, Sylvie Schulze, Reinhard Guthke, Henkel S. G.

Date Published: 2nd Mar 2015

Journal: EXCLI J

Abstract (Expand)

Only few Candida species, e.g., Candida albicans, Candida glabrata, Candida dubliniensis, and Candida parapsilosis, are successful colonizers of a human host. Under certain circumstances these species ...

Authors: Bernhard Hube, Ilse Jacobsen, Polke M.

Date Published: 24th Feb 2015

Journal: Adv Appl Microbiol

Abstract (Expand)

Inference of inter-species gene regulatory networks based on gene expression data is an important computational method to predict pathogen-host interactions (PHIs). Both the experimental setup and the ...

Author: Schulze S.,Henkel S. G.,Driesch D.,Guthke R.,Linde J.

Date Published: 6th Feb 2015

Journal: Front Microbiol

Abstract (Expand)

Candida albicans is the most important fungal pathogen of humans, causing severe infections, especially in nosocomial and immunocompromised settings. However, it is also the most prevalent fungus of ...

Author: Cottier F.,Tan A. S.,Chen J.,Lum J.,Zolezzi F.,Poidinger M.,Pavelka N.

Date Published: 1st Feb 2015

Journal: G3 (Bethesda)

Abstract (Expand)

The successful treatment of infectious diseases requires interdisciplinary studies of all aspects of infection processes. The overarching combination of experimental research and theoretical analysis ...

Authors: Sandra Timme, Marc Thilo Figge, Medyukhina A.,Mokhtari Z.

Date Published: 29th Jan 2015

Journal: Cytometry A

Abstract (Expand)

Verticillium hemipterigenum (anamorph Torrubiella hemipterigena) is an entomopathogenic fungus and produces a broad range of secondary metabolites. Here, we present the draft genome sequence of the ...

Authors: Axel Brakhage, Reinhard Guthke, Jörg Linde, Horn F.,Habel A.,Scharf D. H.,Dworschak J.,Hertweck C.

Date Published: 24th Jan 2015

Journal: Genome Announc

Abstract (Expand)

Candida glabrata is the second most common pathogenic Candida species and has emerged as a leading cause of nosocomial fungal infections. Its reduced susceptibility to antifungal drugs and its close ...

Authors: Jörg Linde, Patricia Sieber, Konstantin Riege, Manja Marz, Reinhard Guthke, Oliver Kurzai, Duggan S.,Weber M.,Horn F.,Hellwig D.,Martin R.

Date Published: 13th Jan 2015

Journal: Nucleic Acids Res

Abstract (Expand)

Polymorphonuclear neutrophilic granulocytes (PMN) as cellular components of innate immunity play a crucial role in the defense against systemic Candida albicans infection. To analyze stimuli that are ...

Authors: Kerstin Hünniger, Marc Thilo Figge, Oliver Kurzai, Bieber K.,Martin R.,Lehnert T.,Loffler J.,Guo R. F.,Riedemann N. C.

Date Published: 24th Dec 2014

Journal: J Immunol

Abstract (Expand)

Following antifungal treatment, Candida albicans, and other human pathogenic fungi can undergo microevolution, which leads to the emergence of drug resistance. However, the capacity for microevolutionary ...

Authors: Jörg Linde, Ilse Jacobsen, Thomas Wolf, Reinhard Guthke, Oliver Kurzai, Bernhard Hube, Wartenberg A.,Martin R.,Schreiner M.,Horn F.,Jenull S.,Kuchler K.,Forche A.,d'Enfert C.,Brunke S.

Date Published: 4th Dec 2014

Journal: PLoS Genet

Abstract (Expand)

Aspergillus fumigatus is a saprotrophic filamentous fungus and also the most prevalent airborne fungal pathogen of humans. Depending on the host's immune status, the variety of diseases caused by ...

Authors: Iordana Shopova, Axel Brakhage, Heinekamp T.,Schmidt H.,Lapp K.,Pahtz V.,Koster-Eiserfunke N.,Kruger T.,Kniemeyer O.

Date Published: 18th Nov 2014

Journal: Semin Immunopathol

Abstract (Expand)

Time-lapse microscopy is an important technique to study the dynamics of various biological processes. The labor-intensive manual analysis of microscopy videos is increasingly replaced by automated ...

Authors: Kerstin Hünniger, Oliver Kurzai, Marc Thilo Figge, Brandes S.,Mokhtari Z.,Essig F.

Date Published: 8th Nov 2014

Journal: Med Image Anal

Abstract (Expand)

Modes of sexual reproduction in eukaryotic organisms are extremely diverse. The human fungal pathogen Candida albicans undergoes a phenotypic switch from the white to the opaque phase in order to become ...

Author: Tao L.,Cao C.,Liang W.,Guan G.,Zhang Q.,Nobile C. J.,Huang G.

Date Published: 21st Oct 2014

Journal: PLoS Genet

Abstract (Expand)

Aspergillus fumigatus is a saprophytic mold that can cause life-threatening infections in immunocompromised patients. In the lung, inhaled conidia are confronted with immune effector cells that attack ...

Authors: Axel Brakhage, Lapp K.,Vodisch M.,Kroll K.,Strassburger M.,Kniemeyer O.,Heinekamp T.

Date Published: 11th Sep 2014

Journal: Front Microbiol

Abstract (Expand)

Fungal pathogens must assimilate local nutrients to establish an infection in their mammalian host. We focus on carbon, nitrogen, and micronutrient assimilation mechanisms, discussing how these influence ...

Authors: Bernhard Hube, Ene I. V.,Brunke S.,Brown A. J.

Date Published: 4th Sep 2014

Journal: Cold Spring Harb Perspect Med

Abstract (Expand)

Lichtheimia corymbifera is a ubiquitous soilborne zygomycete fungus, which is an opportunistic human pathogen in immunocompromised patients. The fungus can cause life-threatening diseases by attacking ...

Authors: Kaswara Kraibooj, Marc Thilo Figge, Park H. R.,Dahse H. M.,Skerka C.,Voigt K.

Date Published: 1st Sep 2014

Journal: Mycoses

Abstract (Expand)

Beyond its well-documented role in reproduction, embryogenesis and maintenance of body tissues, vitamin A has attracted considerable attention due to its immunomodulatory effects on both the innate and ...

Authors: Tilman Klassert, Hortense Slevogt, Hanisch A.,Brauer J.,Klaile E.,Heyl K. A.,Mansour M. K.,Tam J. M.,Vyas J. M.

Date Published: 17th Aug 2014

Journal: Med Microbiol Immunol

Abstract (Expand)

Streptomyces iranensis HM 35 has been shown to exhibit 72.7% DNA-DNA similarity to the important drug rapamycin (sirolimus)-producing Streptomyces rapamycinicus NRRL5491. Here, we report the genome ...

Authors: Reinhard Guthke, Axel Brakhage, Jörg Linde, Horn F.,Schroeckh V.,Netzker T.

Date Published: 19th Jul 2014

Journal: Genome Announc

Abstract (Expand)

The human pathogenic fungus Aspergillus fumigatus normally lives as a soil saprophyte. Its environment includes poorly oxygenated substrates that also occur during tissue invasive growth of the fungus ...

Authors: Jörg Linde, Reinhard Guthke, Olaf Kniemeyer, Axel Brakhage, Hillmann F.,Beckmann N.,Cyrulies M.,Strassburger M.,Heinekamp T.,Haas H.

Date Published: 7th Jul 2014

Journal: Mol Microbiol

Abstract (Expand)

Candida albicans demonstrates three main growth morphologies: yeast, pseudohyphal and true hyphal forms. Cell separation is distinct in these morphological forms and the process of separation is closely ...

Author: Milne S. W.,Cheetham J.,Lloyd D.,Shaw S.,Moore K.,Paszkiewicz K. H.,Aves S. J.,Bates S.

Date Published: 29th Jun 2014

Journal: Fungal Genet Biol

Abstract (Expand)

OBJECTIVES: Candida albicans is an important fungal pathogen that can cause life-threatening disseminated infections. To determine the efficacy of therapy in murine models, a determination of renal ...

Authors: Ilse Jacobsen, Oliver Kurzai, Bernhard Hube, Matthias Brock, Luttich A.

Date Published: 20th Jun 2014

Journal: J Antimicrob Chemother

Abstract (Expand)

Little is known regarding the role of NK cells during primary and secondary disseminated Candida albicans infection. We assessed the role of NK cells for host defense against candidiasis in immunocompetent, ...

Authors: Ilse Jacobsen, Bernhard Hube, Oliver Kurzai, Quintin J.,Voigt J.,van der Voort R.,Verschueren I.,Giamarellos-Bourboulis E. J.,van der Meer J. W.,Joosten L. A.,Netea M. G.

Date Published: 27th May 2014

Journal: Eur J Immunol

Abstract (Expand)

Unlike induced Foxp3(+) regulatory T cells (Foxp3(+) iTreg) that have been shown to play an essential role in the development of protective immunity to the ubiquitous mold Aspergillus fumigatus, ...

Authors: Tanja Bedke, Max Topp, Iannitti R. G.,De Luca A.,Giovannini G.,Fallarino F.,Berges C.,Latge J. P.,Einsele H.,Romani L.

Date Published: 13th May 2014

Journal: Immunol Cell Biol

Abstract (Expand)

Oral candidiasis remains one of the most common forms of Candida infections and occurs if the balance between host, Candida and microbiota is disturbed, e.g., by broad spectrum antibiotics or ...

Authors: Bernhard Hube, Ilse Jacobsen, Hebecker B.,Naglik J. R.

Date Published: 7th May 2014

Journal: Expert Rev Anti Infect Ther

Abstract (Expand)

Nitrogen is one of the key nutrients for microbial growth. During infection, pathogenic fungi like C. albicans need to acquire nitrogen from a broad range of different and changing sources inside the ...

Authors: Jörg Linde, Matthias Brock, Reinhard Guthke, Bernhard Hube, Ramachandra S.,Brunke S.

Date Published: 20th Mar 2014

Journal: PLoS One

Abstract (Expand)

Human fungal pathogens are distributed throughout their kingdom, suggesting that pathogenic potential evolved independently. Candida albicans is the most virulent member of the CUG clade of yeasts and ...

Authors: Ilse Jacobsen, Bernhard Hube, Wilson D.,Mayer F. L.,Miramon P.,Citiulo F.,Slesiona S.

Date Published: 7th Mar 2014

Journal: Eukaryot Cell

Abstract (Expand)

Candida albicans bloodstream infection is increasingly frequent and can result in disseminated candidiasis associated with high mortality rates. To analyze the innate immune response against C. albicans, ...

Authors: Kerstin Hünniger, Marc Thilo Figge, Oliver Kurzai, Lehnert T.,Bieber K.,Martin R.

Date Published: 20th Feb 2014

Journal: PLoS Comput Biol

Abstract (Expand)

Plant hormones involving salicylic acid (SA), jasmonic acid (JA), ethylene (Et), and auxin, gibberellins, and abscisic acid (ABA) are known to regulate host immune responses. However, plant hormone ...

Authors: Thomas Dandekar, Naseem M.,Kunz M.

Date Published: 13th Feb 2014

Journal: Bioinform Biol Insights

Abstract:

Not specified

Authors: Axel Brakhage, Scharf D. H.,Heinekamp T.

Date Published: 30th Jan 2014

Journal: PLoS Pathog

Abstract (Expand)

Candida albicans is the most common opportunistic fungal pathogen of the human mucosal flora, frequently causing infections. The fungus is responsible for invasive infections in immunocompromised ...

Authors: Bernhard Hube, Mech F.,Wilson D.,Lehnert T.,Thilo Figge M.

Date Published: 20th Nov 2013

Journal: Cytometry A

Abstract (Expand)

BACKGROUND: Natural killer (NK) cells are innate lymphocytes with potent cytotoxic activity. Whereas activity of NK cells has been demonstrated against the fungal pathogens Aspergillus fumigatus and ...

Authors: Kerstin Hünniger, Ilse Jacobsen, Bernhard Hube, Jürgen Löffler, Oliver Kurzai, Voigt J.,Bouzani M.,Barz D.

Date Published: 25th Oct 2013

Journal: J Infect Dis

Abstract (Expand)

The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the ...

Authors: Bernhard Hube, Wilson D.,Hebecker B.,Moyes D. L.,Miramon P.,Jablonowski N.,Wisgott S.,Allert S.,Naglik J. R.

Date Published: 29th Jul 2013

Journal: Antimicrob Agents Chemother

Abstract:

Not specified

Authors: Ilse Jacobsen, Barbara Schaarschmidt, Bernhard Hube, Michael Bauer, Otto G. P.,Ludewig K.

Date Published: 12th Jun 2013

Journal: Crit Care

Abstract (Expand)

BACKGROUND: Although Candida albicans and Candida dubliniensis are most closely related, both species behave significantly different with respect to morphogenesis and virulence. In order to gain further ...

Author: Grumaz C.,Lorenz S.,Stevens P.,Lindemann E.,Schock U.,Retey J.,Rupp S.,Sohn K.

Date Published: 4th Apr 2013

Journal: BMC Genomics

Abstract (Expand)

Systemic infections of humans with the fungal pathogen Candida albicans are associated with a high mortality rate. Currently, efficient treatment of these infections is hampered by the relatively low ...

Authors: Bernhard Hube, Mayer F. L.,Wilson D.

Date Published: 22nd Mar 2013

Journal: PLoS One

Abstract (Expand)

Although morphological plasticity is a central virulence trait of Candida albicans, the number of filament-associated genes and the interplay of mechanisms regulating their expression remain unknown. ...

Authors: Daniela Albrecht-Eckardt, Bernhard Hube, Kerstin Hünniger, Oliver Kurzai, Martin R.,Brunke S.

Date Published: 14th Mar 2013

Journal: PLoS One

Abstract (Expand)

The amino acid cysteine has long been known to be toxic at elevated levels for bacteria, fungi, and humans. However, mechanisms of cysteine tolerance in microbes remain largely obscure. Here we show ...

Authors: Ilse Jacobsen, Bernhard Hube, Hennicke F.,Grumbt M.,Lermann U.,Ueberschaar N.,Palige K.,Bottcher B.,Staib C.,Morschhauser J.,Monod M.,Hertweck C.,Staib P.

Date Published: 15th Feb 2013

Journal: Eukaryot Cell

Abstract (Expand)

Despite their classical role as transcriptional repressors, several histone deacetylases, including the baker's yeast Set3/Hos2 complex (Set3C), facilitate gene expression. In the dimorphic human ...

Author: Hnisz D.,Bardet A. F.,Nobile C. J.,Petryshyn A.,Glaser W.,Schock U.,Stark A.,Kuchler K.

Date Published: 14th Dec 2012

Journal: PLoS Genet

Abstract (Expand)

Fungi produce a multitude of low-molecular-mass compounds known as secondary metabolites, which have roles in a range of cellular processes such as transcription, development and intercellular ...

Author: Brakhage Axel A

Date Published: 26th Nov 2012

Journal: Nat. Rev. Microbiol.

Abstract:

ABSTRACT:

Author: Müller Sebastian,Baldin Clara,Groth Marco,Guthke Reinhard,Kniemeyer Olaf,Brakhage Axel A,Valiante Vito

Date Published: 2nd Oct 2012

Journal: BMC Genomics

Abstract (Expand)

The ability to adapt to diverse micro-environmental challenges encountered within a host is of pivotal importance to the opportunistic fungal pathogen Candida albicans. We have quantified C. albicans ...

Authors: Jörg Linde, Bernhard Hube, Reinhard Guthke, Tierney L.,Muller S.,Brunke S.,Molina J. C.,Schock U.,Kuchler K.

Date Published: 12th Mar 2012

Journal: Front Microbiol

Abstract (Expand)

BACKGROUND: In System Biology, iterations of wet-lab experiments followed by modelling approaches and model-inspired experiments describe a cyclic workflow. This approach is especially useful for the ...

Authors: Jörg Linde, Axel Brakhage, Reinhard Guthke, Hortschansky P.,Fazius E.,Haas H.

Date Published: 19th Jan 2012

Journal: BMC Syst Biol

Abstract (Expand)

Non-invasive imaging techniques in microbial disease models have delivered valuable insights in the intimate pathogen-host interplay during infection. Here we describe evaluation and validation of a ...

Author: Donat Stefanie,Hasenberg Mike,Schäfer Tina,Ohlsen Knut,Gunzer Matthias,Einsele Hermann,Löffler Jürgen,Beilhack Andreas,Krappmann Sven

Date Published: 2012

Journal: Virulence

Abstract (Expand)

FungiDB (http://FungiDB.org) is a functional genomic resource for pan-fungal genomes that was developed in partnership with the Eukaryotic Pathogen Bioinformatic resource center (http://EuPathDB.org). ...

Author: Stajich Jason E,Harris Todd,Brunk Brian P,Brestelli John,Fischer Steve,Harb Omar S,Kissinger Jessica C,Li Wei,Nayak Vishal,Pinney Deborah F,Stoeckert Chris J,Roos David S

Date Published: 7th Nov 2011

Journal: Nucleic Acids Res.

Abstract (Expand)

FungiFun assigns functional annotations to fungal genes or proteins and performs gene set enrichment analysis. Based on three different classification methods (FunCat, GO and KEGG), FungiFun categorizes ...

Authors: Jörg Linde, Reinhard Guthke, Priebe S.,Albrecht D.,Brakhage A. A.

Date Published: 10th Nov 2010

Journal: Fungal Genet Biol

Abstract (Expand)

Candida albicans is an important human opportunistic fungal pathogen which is frequently found as part of the normal human microbiota. It is well accepted that the fungus interacts with other components ...

Authors: None

Date Published: No date defined

Journal: Cellular Microbiology

Abstract (Expand)

The identification of novel transcription factors associated with antifungal response may allow the discovery of fungus-specific targets for new therapeutic strategies. A collection of 241 Candida ...

Author: Vandeputte P.,Pradervand S.,Ischer F.,Coste A. T.,Ferrari S.,Harshman K.,Sanglard D.

Date Published: No date defined

Journal: Eukaryot Cell

Abstract (Expand)

Candida albicans is a common cause of life-threatening fungal bloodstream infections. In the murine model of systemic candidiasis, the kidney is the primary target organ while the fungal load declines ...

Authors: Michael Bauer, Jörg Linde, Ilse Jacobsen, Hebecker B.,Vlaic S.,Conrad T.,Brunke S.,Kapitan M.,Hube B.

Date Published: No date defined

Journal: Sci Rep

Abstract (Expand)

Human fungal pathogens like Candida albicans respond to host immune surveillance by rapidly adapting their transcriptional programs. Chromatin assembly factors are involved in the regulation of stress ...

Author: Tscherner M.,Zwolanek F.,Jenull S.,Sedlazeck F. J.,Petryshyn A.,Frohner I. E.,Mavrianos J.,Chauhan N.,von Haeseler A.,Kuchler K.

Date Published: No date defined

Journal: PLoS Pathog

Abstract (Expand)

Aspergillus fumigatus is a common airborne fungal pathogen of humans and a significant source of mortality in immunocompromised individuals. Here, we provide the most extensive cell wall proteome ...

Authors: Thorsten Heinekamp, Thomas Krüger, Esther Weiß, Kerstin Hünniger, Jürgen Löffler, Oliver Kurzai, Hermann Einsele, Olaf Kniemeyer, Axel Brakhage, Voltersen V.,Blango M. G.,Herrmann S.,Schmidt F.,Strassburger M.,Bacher P.,Lother J.,Liu H.,Hortschansky P.,Scheffold A.,Krappmann S.,Nietzsche S.,Filler S. G.,Reichard U.

Date Published: No date defined

Journal: MBio

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