Cultivation of A. fumigatus in an O2-controlled fermenter and analysed its minute-scale responses to O2 limitation. Transcriptome sequencing revealed a group of genes underlying a rapid and highly dynamic regulation.
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Within the de.NBI project my functions in the de.NBI-SysBio node comprise content curation, requirements elicitation, and community engagement for the users of biochemical reaction kinetics database SABIO-RK as well as of the data management platform SEEK.
I study the analysis of high-throughput transcriptom and genome data.
For transcritom data (RNA-Seq, microarrays), I perform preprocessing and statistics to identify differentially expressed genes, as well as their functional analysis. My main focus is the analysis of transcriptom data
from human fungal pathogens in infection related conditions (f.e. nutrient limitation) as well as during the interaction with the host (dual RNA-seq).
Experimental data is used to set up mathematical models for
Projects: FungiNet total
Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI), Friedrich Schiller University Jena, Institute of Microbiology, Dept. of Microbiology and Molecular Biology
Disciplines: Not specified
Roles: Not specified
Expertise: Not specified
Tools: Not specified
Head of the subgroup Stress and Immunoproteomics of the Department of Molecular and Applied Microbiology Department at the HKI
Cross talk of Aspergillus fumigatus with neutrophilic granulocytes
Date Published: 7th Jul 2014
Journal: Mol Microbiol
PubMed ID: 24948085