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Cultivation of A. fumigatus in an O2-controlled fermenter and analysed its minute-scale responses to O2 limitation. Transcriptome sequencing revealed a group of genes underlying a rapid and highly dynamic regulation.
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Created: 5th Sep 2017 at 09:21
Last updated: 4th Jun 2018 at 12:41
Last used: 4th Oct 2023 at 18:22

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Projects: FungiNet total, Z2
Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

Roles: Project Coordinator
Expertise: Aspergillus fumigatus, Hypoxia, Stress response, Proteomics
Tools: Proteomics, LC-MS/MS, 2D-gel electrophoresis
Head of the subgroup Stress and Immunoproteomics of the Department of Molecular and Applied Microbiology Department at the HKI
I study the analysis of high-throughput transcriptom and genome data.
For transcritom data (RNA-Seq, microarrays), I perform preprocessing and statistics to identify differentially expressed genes, as well as their functional analysis. My main focus is the analysis of transcriptom data
from human fungal pathogens in infection related conditions (f.e. nutrient limitation) as well as during the interaction with the host (dual RNA-seq).
Experimental data is used to set up mathematical models for
...
Projects: INF, FungiNet total, A1, A2, FungiNet A - Aspergillus projects, A3, A4 (E), A5, A6, FungiNet C - Candida projects, C1, C2, C3, C4 (E), C5, C6 (E), FungiNet B - Bioinformatics projects, B3 (E)
Institutions: HITS Heidelberger Institut für Theoretische Studien gGmbH
Expertise: Biochemistry, Phytopathology, Molecular Biology, Data Curation, Microbiology, Data Management
Within the de.NBI project my functions in the de.NBI-SysBio node comprise content curation, requirements elicitation, and community engagement for the users of biochemical reaction kinetics database SABIO-RK as well as of the data management platform SEEK.
Cross talk of Aspergillus fumigatus with neutrophilic granulocytes
Abstract (Expand)
Authors: F. Hillmann, Jörg Linde, N. Beckmann, M. Cyrulies, M. Strassburger, T. Heinekamp, H. Haas, Reinhard Guthke, Olaf Kniemeyer, Axel Brakhage
Date Published: 7th Jul 2014
Journal: Mol Microbiol
PubMed ID: 24948085
Citation:
Type: Template_RNA-seq_V1.9
Creators: Jörg Linde, Falk Hillmann, Olaf Kniemeyer
Contributor: Maja Rey
Type: Template_RNA-seq_V1.9
Creators: Jörg Linde, Falk Hillmann, Olaf Kniemeyer
Contributor: Maja Rey
Type: Template_RNA-seq_V1.9
Creators: Jörg Linde, Falk Hillmann, Olaf Kniemeyer
Contributor: Maja Rey
Type: Template_RNA-seq_V1.9
Creators: Jörg Linde, Falk Hillmann, Olaf Kniemeyer
Contributor: Maja Rey
Type: Template_RNA-seq_V1.9
Creators: Jörg Linde, Falk Hillmann, Olaf Kniemeyer
Contributor: Maja Rey