Abstract (Expand)

In systems biology, researchers aim to understand complex biological systems as a whole, which is often achieved by mathematical modelling and the analyses of high-throughput data. In this review, we ...

Authors: Andreas Dix, Reinhard Guthke, Jörg Linde, Vlaic S.

Date Published: 27th Apr 2016

Journal: Clin Microbiol Infect

Abstract (Expand)

In the emerging field of systems biology of fungal infection, one of the central roles belongs to the modeling of gene regulatory networks (GRNs). Utilizing omics-data, GRNs can be predicted by ...

Authors: Reinhard Guthke, Theresia Conrad, Ekaterina Shelest, Jörg Linde, Gerber S.,Vlaic S.,Durmus S.,Cakir T.,Sevilgen F. E.

Date Published: 22nd Apr 2016

Journal: Front Microbiol

Abstract (Expand)

Organisms constantly interact with other species through physical contact which leads to changes on the molecular level, for example the transcriptome. These changes can be monitored for all genes, ...

Authors: Sylvie Schulze, Reinhard Guthke, Jörg Linde, Schleicher J.

Date Published: 31st Mar 2016

Journal: Front Microbiol

Abstract (Expand)

Invasive aspergillosis (IA) is a devastating opportunistic infection and its treatment constitutes a considerable burden for the health care system. Immunocompromised patients are at an increased risk ...

Authors: Andreas Dix, Reinhard Guthke, Hermann Einsele, Jörg Linde, Jürgen Löffler, Czakai K.,Springer J.,Fliesser M.,Bonin M.,Schmitt A. L.

Date Published: 21st Mar 2016

Journal: Front Microbiol

Abstract (Expand)

Aspergillus fumigatus is the species that most commonly causes the opportunistic infection invasive aspergillosis (IA) in patients being treated for hematological malignancies. Little is known about ...

Authors: Jürgen Löffler, Hermann Einsele, Reinhard Guthke, Axel Brakhage, Olaf Kniemeyer, Teutschbein J.,Simon S.,Lother J.,Springer J.,Hortschansky P.,Morton C. O.,Conneally E.,Rogers T. R.

Date Published: 15th Mar 2016

Journal: J Proteome Res

Abstract (Expand)

Here, we report the draft genome sequence of Aspergillus calidoustus (strain SF006504). The functional annotation of A. calidoustus predicts a relatively large number of secondary metabolite gene ...

Authors: Jörg Linde, Reinhard Guthke, Axel Brakhage, Vito Valiante, Horn F.,Mattern D. J.,Walther G.,Scherlach K.,Martin K.,Petzke L.

Date Published: 12th Mar 2016

Journal: Genome Announc

Abstract (Expand)

Recent and rapidly evolving progress on high-throughput measurement techniques and computational performance has led to the emergence of new disciplines, such as systems medicine and translational ...

Authors: Theresia Conrad, Reinhard Guthke, Jörg Linde, Schleicher J.,Gustafsson M.,Cedersund G.

Date Published: 10th Feb 2016

Journal: Brief Funct Genomics


Not specified

Authors: Reinhard Guthke, Durmus S.,Cakir T.

Date Published: 4th Feb 2016

Journal: Front Microbiol

Abstract (Expand)

Intestinal epithelial cells (IEC) form a tight barrier to the gut lumen. Paracellular permeability of the intestinal barrier is regulated by tight junction proteins and can be modulated by microorganisms ...

Authors: Sylvie Schulze, Daniela Albrecht-Eckardt, Kerstin Hünniger, Jörg Linde, Reinhard Guthke, Oliver Kurzai, Bohringer M.,Pohlers S.,Piegsa J.,Weber M.,Martin R.

Date Published: 12th Jan 2016

Journal: Cell Microbiol

Abstract (Expand)

Mitogen activated protein kinases (MAPKs) are highly conserved in eukaryotic organisms. In pathogenic fungi, their activities were assigned to different physiological functions including drug adaptation ...

Authors: Reinhard Guthke, Axel Brakhage, Jörg Linde, Altwasser R.,Baldin C.,Weber J.,Kniemeyer O.,Valiante V.

Date Published: 10th Sep 2015

Journal: PLoS One

Abstract (Expand)

The genus Penicillium belongs to the phylum Ascomycota and includes a variety of fungal species important for food and drug production. We report the draft genome sequence of Penicillium brasilianum ...

Authors: Jörg Linde, Reinhard Guthke, Axel Brakhage, Horn F.,Mattern D. J.,Walther G.,Valiante V.

Date Published: 5th Sep 2015

Journal: Genome Announc

Abstract (Expand)

More than 80 years after its discovery, penicillin is still a widely used and commercially highly important antibiotic. Here, we analyse the metabolic network of penicillin synthesis in Penicillium ...

Authors: Reinhard Guthke, Stefan Schuster, Prausse M. T.,Schauble S.

Date Published: 19th Aug 2015

Journal: Biotechnol Bioeng

Abstract (Expand)

Fungal infections have increased dramatically in the last 2 decades, and fighting infectious diseases requires innovative approaches such as the combination of two drugs acting on different targets or ...

Authors: Vito Valiante, Olaf Kniemeyer, Axel Brakhage, Monteiro M. C.,Martin J.,Altwasser R.,El Aouad N.,Gonzalez I.,Mellado E.,Palomo S.,de Pedro N.,Perez-Victoria I.,Tormo J. R.,Vicente F.,Reyes F.,Genilloud O.

Date Published: 8th Jun 2015

Journal: Antimicrob Agents Chemother

Abstract (Expand)

Pathogens manipulate the cellular mechanisms of host organisms via pathogen-host interactions (PHIs) in order to take advantage of the capabilities of host cells, leading to infections. The crucial ...

Authors: Reinhard Guthke, Durmus S.,Cakir T.,Ozgur A.

Date Published: 9th Apr 2015

Journal: Front Microbiol

Abstract (Expand)

Sepsis is a clinical syndrome that can be caused by bacteria or fungi. Early knowledge on the nature of the causative agent is a prerequisite for targeted anti-microbial therapy. Besides currently used ...

Authors: Andreas Dix, Kerstin Hünniger, Reinhard Guthke, Oliver Kurzai, Jörg Linde, Weber M.

Date Published: 11th Mar 2015

Journal: Front Microbiol

Abstract (Expand)

Gene regulatory network inference is a systems biology approach which predicts interactions between genes with the help of high-throughput data. In this review, we present current and updated network ...

Authors: Jörg Linde, Sylvie Schulze, Reinhard Guthke, Henkel S. G.

Date Published: 2nd Mar 2015

Journal: EXCLI J

Abstract (Expand)

Verticillium hemipterigenum (anamorph Torrubiella hemipterigena) is an entomopathogenic fungus and produces a broad range of secondary metabolites. Here, we present the draft genome sequence of the ...

Authors: Axel Brakhage, Reinhard Guthke, Jörg Linde, Horn F.,Habel A.,Scharf D. H.,Dworschak J.,Hertweck C.

Date Published: 24th Jan 2015

Journal: Genome Announc

Abstract (Expand)

Candida glabrata is the second most common pathogenic Candida species and has emerged as a leading cause of nosocomial fungal infections. Its reduced susceptibility to antifungal drugs and its close ...

Authors: Jörg Linde, Patricia Sieber, Konstantin Riege, Manja Marz, Reinhard Guthke, Oliver Kurzai, Duggan S.,Weber M.,Horn F.,Hellwig D.,Martin R.

Date Published: 13th Jan 2015

Journal: Nucleic Acids Res

Abstract (Expand)

Following antifungal treatment, Candida albicans, and other human pathogenic fungi can undergo microevolution, which leads to the emergence of drug resistance. However, the capacity for microevolutionary ...

Authors: Jörg Linde, Ilse Jacobsen, Thomas Wolf, Reinhard Guthke, Oliver Kurzai, Bernhard Hube, Wartenberg A.,Martin R.,Schreiner M.,Horn F.,Jenull S.,Kuchler K.,Forche A.,d'Enfert C.,Brunke S.

Date Published: 4th Dec 2014

Journal: PLoS Genet

Abstract (Expand)

Streptomyces iranensis HM 35 has been shown to exhibit 72.7% DNA-DNA similarity to the important drug rapamycin (sirolimus)-producing Streptomyces rapamycinicus NRRL5491. Here, we report the genome ...

Authors: Reinhard Guthke, Axel Brakhage, Jörg Linde, Horn F.,Schroeckh V.,Netzker T.

Date Published: 19th Jul 2014

Journal: Genome Announc

Abstract (Expand)

The human pathogenic fungus Aspergillus fumigatus normally lives as a soil saprophyte. Its environment includes poorly oxygenated substrates that also occur during tissue invasive growth of the fungus ...

Authors: Jörg Linde, Reinhard Guthke, Olaf Kniemeyer, Axel Brakhage, Hillmann F.,Beckmann N.,Cyrulies M.,Strassburger M.,Heinekamp T.,Haas H.

Date Published: 7th Jul 2014

Journal: Mol Microbiol

Abstract (Expand)

Nitrogen is one of the key nutrients for microbial growth. During infection, pathogenic fungi like C. albicans need to acquire nitrogen from a broad range of different and changing sources inside the ...

Authors: Jörg Linde, Matthias Brock, Reinhard Guthke, Bernhard Hube, Ramachandra S.,Brunke S.

Date Published: 20th Mar 2014

Journal: PLoS One

Abstract (Expand)

Fungi produce a multitude of low-molecular-mass compounds known as secondary metabolites, which have roles in a range of cellular processes such as transcription, development and intercellular ...

Author: Brakhage Axel A

Date Published: 26th Nov 2012

Journal: Nat. Rev. Microbiol.



Author: Müller Sebastian,Baldin Clara,Groth Marco,Guthke Reinhard,Kniemeyer Olaf,Brakhage Axel A,Valiante Vito

Date Published: 2nd Oct 2012

Journal: BMC Genomics

Abstract (Expand)

The ability to adapt to diverse micro-environmental challenges encountered within a host is of pivotal importance to the opportunistic fungal pathogen Candida albicans. We have quantified C. albicans ...

Authors: Jörg Linde, Bernhard Hube, Reinhard Guthke, Tierney L.,Muller S.,Brunke S.,Molina J. C.,Schock U.,Kuchler K.

Date Published: 12th Mar 2012

Journal: Front Microbiol

Abstract (Expand)

BACKGROUND: In System Biology, iterations of wet-lab experiments followed by modelling approaches and model-inspired experiments describe a cyclic workflow. This approach is especially useful for the ...

Authors: Jörg Linde, Axel Brakhage, Reinhard Guthke, Hortschansky P.,Fazius E.,Haas H.

Date Published: 19th Jan 2012

Journal: BMC Syst Biol

Abstract (Expand)

FungiDB ( is a functional genomic resource for pan-fungal genomes that was developed in partnership with the Eukaryotic Pathogen Bioinformatic resource center ( ...

Author: Stajich Jason E,Harris Todd,Brunk Brian P,Brestelli John,Fischer Steve,Harb Omar S,Kissinger Jessica C,Li Wei,Nayak Vishal,Pinney Deborah F,Stoeckert Chris J,Roos David S

Date Published: 7th Nov 2011

Journal: Nucleic Acids Res.

Abstract (Expand)

FungiFun assigns functional annotations to fungal genes or proteins and performs gene set enrichment analysis. Based on three different classification methods (FunCat, GO and KEGG), FungiFun categorizes ...

Authors: Jörg Linde, Reinhard Guthke, Priebe S.,Albrecht D.,Brakhage A. A.

Date Published: 10th Nov 2010

Journal: Fungal Genet Biol

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