Projects: Not specified
Institutions: Not specified
Projects: B1, B2, FungiNet B - Bioinformatics projects, FungiNet total
Institutions: Julius Maximilians University Würzburg, Biocenter, Department of Bioinformatics
Roles: PhD Student
Expertise: Proteomics, Lichtheimia corymbifera, Data Management, protein-protein interaction, Integrative Data Analysis, Aspergillus fumigatus, Bioinformatics, Candida albicans, Host-Pathogen Interaction
Tools: Phosphoproteomics, Transcriptomics, R, JavaScript, Network analysis, Proteomics, MySQL, PHP, Python, Java
Projects: FungiNet A - Aspergillus projects, FungiNet total, A1
Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

Roles: Postdoc
Expertise: Molecular Biology, Host-Pathogen Interaction, Aspergillus fumigatus, Immune evasion, fungal pathogens, infection models
Tools: Molecular Biology, Mouse models
Projects: FungiNet total, Z2
Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)

Roles: Project Coordinator
Expertise: Aspergillus fumigatus, Hypoxia, Stress response, Proteomics
Tools: Proteomics, LC-MS/MS, 2D-gel electrophoresis
Head of the subgroup Stress and Immunoproteomics of the Department of Molecular and Applied Microbiology Department at the HKI
Adaptation of the previously developed virtual infection model of Aspergillus fumigatus in a *human* alveolus.
This model comprises a hybrid agent-based model of a single murine alveolus. The alveolus is represented in a realistic to-scale representation and contains the cell types of alveolar epithelial cells (AEC) of type 1 and 2 as well as the pores of Kohn (PoK).
Furthermore, in this model, depending on the infection dose multiple A. fumigatus conidium are inserted into the alveolus and the
...
Creators: Sandra Timme, Marco Blickensdorf
Contributor: Sandra Timme
Model type: Agent based modelling
Model format: Not specified
Environment: Not specified
Organism: Aspergillus fumigatus
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
This model comprises a hybrid agent-based model of a single human alveolus. The alveolus is represented in a realistic to-scale representation and contains the cell types of alveolar epithelial cells (AEC) of type 1 and 2 as well as the pores of Kohn (PoK). A single A. fumigatus conidium in inserted into the alveolus and the AEC, where the conidium is located secretes chemokines. Chemokine secretion is modelled using the partial differential equation of the diffusion equation and numerically
...
Creator: Johannes Pollmächer
Contributor: Sandra Timme
Model type: Agent based modelling
Model format: Not specified
Environment: Not specified
Organism: Aspergillus fumigatus
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
Abstract (Expand)
Authors: J. Pollmacher, Sandra Timme, Stefan Schuster, Axel Brakhage, Peter Zipfel, Marc Thilo Figge
Date Published: 13th Jun 2016
Journal: Sci Rep
PubMed ID: 27291424
Citation: Sci Rep. 2016 Jun 13;6:27807. doi: 10.1038/srep27807.
Abstract (Expand)
Authors: J. Pollmacher, Marc Thilo Figge
Date Published: 16th Jun 2015
Journal: Front Microbiol
PubMed ID: 26074897
Citation: Front Microbiol. 2015 May 28;6:503. doi: 10.3389/fmicb.2015.00503. eCollection 2015.
Abstract (Expand)
Authors: F. Schmidt, A. Thywissen, M. Goldmann, C. Cunha, Z. Cseresnyes, H. Schmidt, M. Rafiq, S. Galiani, M. H. Graler, G. Chamilos, J. F. Lacerda, A. Jr Campos, C. Eggeling, Marc Thilo Figge, Thorsten Heinekamp, S. G. Filler, A. Carvalho, Axel Brakhage
Date Published: 18th Aug 2020
Journal: Cell Rep
PubMed ID: 32814035
Citation: Cell Rep. 2020 Aug 18;32(7):108017. doi: 10.1016/j.celrep.2020.108017.
Abstract (Expand)
Authors: Prasad Dasari, Naile Koleci, Iordana Shopova, D. Wartenberg, Niklas Beyersdorf, Stefanie Dietrich, A. Sahagun-Ruiz, Marc Thilo Figge, Christine Skerka, Axel Brakhage, Peter Zipfel
Date Published: 12th Dec 2019
Journal: Front Immunol
PubMed ID: 31824478
Citation: Front Immunol. 2019 Nov 22;10:2573. doi: 10.3389/fimmu.2019.02573. eCollection 2019.
Abstract (Expand)
Authors: Prasad Dasari, Iordana Shopova, M. Stroe, D. Wartenberg, H. Martin-Dahse, Niklas Beyersdorf, P. Hortschansky, Stefanie Dietrich, Z. Cseresnyes, Marc Thilo Figge, M. Westermann, Christine Skerka, Axel Brakhage, Peter Zipfel
Date Published: 1st Sep 2018
Journal: Front Immunol
PubMed ID: 30166981
Citation: Front Immunol. 2018 Aug 3;9:1635. doi: 10.3389/fimmu.2018.01635. eCollection 2018.
Abstract (Expand)
Authors: Z. Cseresnyes, M. I. A. Hassan, H. M. Dahse, Kerstin Voigt, Marc Thilo Figge
Date Published: 26th Jun 2020
Journal: Front Microbiol
PubMed ID: 32582113
Citation: Front Microbiol. 2020 Jun 5;11:1193. doi: 10.3389/fmicb.2020.01193. eCollection 2020.