Hypoxia

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Projects: INF, Z2

Expertise: Data Management, Integrative Data Analysis, Bioinformatics, Systems Biology, Statistics

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Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

The yeast Candida albicans and the filamentous fungus Aspergillus fumigatus are by far the most important causes of life-threatening invasive mycoses in Europe. Despite the increasing incidence of these infections, the current diagnosis is still difficult and often too late, and options for therapies are limited. Moreover, A. fumigatus and C. albicans have developed multiple sophisticated, specific and unique pathogenicity mechanisms. Many of these mechanisms are not well understood. Research on ...

Projects: FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, A1, A2, A3, A4 (E), A5, B1, B2, B3 (E), B4, C1, C2, C3, C4 (E), C5, C6 (E), Z2, Z1, B5, A6, A7, A8, C7

Web page: http://www.funginet.de/home.html

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Z2

In project Z2 a sophisticated proteome analysis platform will be provided based on 2D-gel electrophoresis (2D-GE), MALDI-TOF and LC-MS/MS techniques to specific A and Cprojects.

Programme: Collaborative Research Center / Transregio 124 "Pathogenic fungi and their human host: Networks of Interaction - FungiNet"

Public web page: http://www.funginet.de/project-z2.html

Organisms: Aspergillus fumigatus, Candida albicans

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Long-term adaptation to hypoxic conditions

Z2

M Vödisch, K Scherlach, R Winkler, C Hertweck, H-P Braun, M Roth,H Haas, E R Werner, A A Brakhage,O Kniemeyer. Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. J. Proteome Res., 2011, 10 (5), 2508–2524

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Submitter: Daniela Albrecht-Eckardt

Studies: Cytosol map, Hypoxia, Mitochondrial map, Normoxia, Transcriptomics

Assays: 2D gel images, 2D gel images, 2D gel images, 2D gel images, Transcriptomics

Snapshots: No snapshots

Created: 28th Apr 2021 at 04:41

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