hypoxia data

Version 2

In project Z2 a sophisticated proteome analysis platform will be provided based on 2D-gel electrophoresis (2D-GE), MALDI-TOF and LC-MS/MS techniques to specific A and Cprojects.

M Vödisch, K Scherlach, R Winkler, C Hertweck, H-P Braun, M Roth,H Haas, E R Werner, A A Brakhage,O Kniemeyer. Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. J. Proteome Res., 2011, 10 (5), 2508–2524

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Cultivation of A. fumigatus in a oxygen controlled, glucose-limited chemostat under aeration with a mixture of nitrogen and normal air resulting in a pO2 of 0.2% oxygen