Publications

Abstract (Expand)

Invasive fungal infections are associated with high mortality rates and are mostly caused by the opportunistic fungi Aspergillus fumigatus and Candida albicans. Immune responses against these fungi are ...

Authors: Andreas Dix, Jörg Linde, Hermann Einsele, Oliver Kurzai, Jürgen Löffler, Czakai K.,Leonhardt I.,Bonin M.

Date Published: 28th Jun 2016

Journal: Sci Rep

Abstract (Expand)

As part of the innate immune system, natural killer (NK) cells are directly involved in the response to fungal infections. Perforin has been identified as the major effector molecule acting against ...

Authors: Dragana Slavkovic Lukic, Jürgen Löffler, Daniela Albrecht-Eckardt, Michael Weber, Stefanie Allert, Oliver Kurzai, Kerstin Hünniger, Voigt J.,Bouzani M.,Martin R.

Date Published: 19th May 2016

Journal: Front Microbiol

Abstract (Expand)

Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate or modulate host immune responses. ...

Authors: Toni Förster, Lydia Kasper, Oliver Kurzai, Bernhard Hube, Moyes D. L.,Wilson D.,Richardson J. P.,Mogavero S.,Tang S. X.,Wernecke J.,Hofs S.,Gratacap R. L.,Robbins J.,Runglall M.,Murciano C.,Blagojevic M.,Thavaraj S.,Hebecker B.,Vizcay G.,Iancu S. I.,Kichik N.,Hader A.,Luo T.,Kruger T.,Kniemeyer O.,Cota E.,Bader O.,Wheeler R. T.,Gutsmann T.,Naglik J. R.

Date Published: 30th Mar 2016

Journal: Nature

Abstract (Expand)

UNLABELLED: Single-celled organisms have different strategies to sense and utilize nutrients in their ever-changing environments. The opportunistic fungal pathogen Candida albicans is a common member ...

Author: Du H.,Guan G.,Li X.,Gulati M.,Tao L.,Cao C.,Johnson A. D.,Nobile C. J.,Huang G.

Date Published: 10th Sep 2015

Journal: MBio

Abstract (Expand)

As a successful commensal and pathogen of humans, Candida albicans encounters a wide range of environmental conditions. Among them, ambient pH, which changes frequently and affects many biological ...

Author: Sun Y.,Cao C.,Jia W.,Tao L.,Guan G.,Huang G.

Date Published: 6th Sep 2015

Journal: Eukaryot Cell

Abstract (Expand)

Candida albicans is associated with humans as both a harmless commensal organism and a pathogen. Cph2 is a transcription factor whose DNA binding domain is similar to that of mammalian sterol response ...

Author: Lane S.,Di Lena P.,Tormanen K.,Baldi P.,Liu H.

Date Published: 6th Sep 2015

Journal: Eukaryot Cell

Abstract (Expand)

The diploid, polymorphic yeast Candida albicans is one of the most important human pathogenic fungi. C. albicans can grow, proliferate and coexist as a commensal on or within the human host for a long ...

Authors: Sybille Dühring, Christine Skerka, Peter Zipfel, Thomas Dandekar, Stefan Schuster, Germerodt S.

Date Published: 30th Jun 2015

Journal: Front Microbiol

Abstract (Expand)

Opportunistic fungal pathogens can cause bloodstream infection and severe sepsis upon entering the blood stream of the host. The early immune response in human blood comprises the elimination of pathogens ...

Authors: Sandra Timme, Kerstin Hünniger, Oliver Kurzai, Marc Thilo Figge, Lehnert T.,Pollmacher J.

Date Published: 19th Jun 2015

Journal: Front Microbiol

Abstract (Expand)

Candida albicans and Candida glabrata account for the majority of candidiasis cases worldwide. Although both species are in the same genus, they differ in key virulence attributes. Within this work, ...

Authors: Kerstin Hünniger, Michael Bauer, Ilse Jacobsen, Marc Thilo Figge, Oliver Kurzai, Duggan S.,Essig F.,Mokhtari Z.,Lehnert T.,Brandes S.,Hader A.,Martin R.

Date Published: 5th May 2015

Journal: Cell Microbiol

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Farnesol, produced by the polymorphic fungus Candida albicans, is the first quorum-sensing molecule discovered in eukaryotes. Its main function is control of C. albicans filamentation, a process closely ...

Authors: Kerstin Hünniger, Oliver Kurzai, Leonhardt I.,Spielberg S.,Weber M.,Albrecht-Eckardt D.,Blass M.,Claus R.,Barz D.,Scherlach K.,Hertweck C.,Loffler J.

Date Published: 19th Mar 2015

Journal: MBio

Abstract (Expand)

Candida albicans is a major cause of bloodstream infection which may present as sepsis and septic shock - major causes of morbidity and mortality world-wide. After invasion of the pathogen, innate ...

Authors: Kerstin Hünniger, Oliver Kurzai, Duggan S.,Leonhardt I.

Date Published: 18th Mar 2015

Journal: Virulence

Abstract (Expand)

Sepsis is a clinical syndrome that can be caused by bacteria or fungi. Early knowledge on the nature of the causative agent is a prerequisite for targeted anti-microbial therapy. Besides currently used ...

Authors: Andreas Dix, Kerstin Hünniger, Reinhard Guthke, Oliver Kurzai, Jörg Linde, Weber M.

Date Published: 11th Mar 2015

Journal: Front Microbiol

Abstract (Expand)

Only few Candida species, e.g., Candida albicans, Candida glabrata, Candida dubliniensis, and Candida parapsilosis, are successful colonizers of a human host. Under certain circumstances these species ...

Authors: Bernhard Hube, Ilse Jacobsen, Polke M.

Date Published: 24th Feb 2015

Journal: Adv Appl Microbiol

Abstract (Expand)

Candida albicans is the most important fungal pathogen of humans, causing severe infections, especially in nosocomial and immunocompromised settings. However, it is also the most prevalent fungus of ...

Author: Cottier F.,Tan A. S.,Chen J.,Lum J.,Zolezzi F.,Poidinger M.,Pavelka N.

Date Published: 1st Feb 2015

Journal: G3 (Bethesda)

Abstract (Expand)

Candida glabrata is the second most common pathogenic Candida species and has emerged as a leading cause of nosocomial fungal infections. Its reduced susceptibility to antifungal drugs and its close ...

Authors: Jörg Linde, Patricia Sieber, Konstantin Riege, Manja Marz, Reinhard Guthke, Oliver Kurzai, Duggan S.,Weber M.,Horn F.,Hellwig D.,Martin R.

Date Published: 13th Jan 2015

Journal: Nucleic Acids Res

Abstract (Expand)

Polymorphonuclear neutrophilic granulocytes (PMN) as cellular components of innate immunity play a crucial role in the defense against systemic Candida albicans infection. To analyze stimuli that are ...

Authors: Kerstin Hünniger, Marc Thilo Figge, Oliver Kurzai, Bieber K.,Martin R.,Lehnert T.,Loffler J.,Guo R. F.,Riedemann N. C.

Date Published: 24th Dec 2014

Journal: J Immunol

Abstract (Expand)

Following antifungal treatment, Candida albicans, and other human pathogenic fungi can undergo microevolution, which leads to the emergence of drug resistance. However, the capacity for microevolutionary ...

Authors: Jörg Linde, Ilse Jacobsen, Thomas Wolf, Reinhard Guthke, Oliver Kurzai, Bernhard Hube, Wartenberg A.,Martin R.,Schreiner M.,Horn F.,Jenull S.,Kuchler K.,Forche A.,d'Enfert C.,Brunke S.

Date Published: 4th Dec 2014

Journal: PLoS Genet

Abstract (Expand)

Time-lapse microscopy is an important technique to study the dynamics of various biological processes. The labor-intensive manual analysis of microscopy videos is increasingly replaced by automated ...

Authors: Kerstin Hünniger, Oliver Kurzai, Marc Thilo Figge, Brandes S.,Mokhtari Z.,Essig F.

Date Published: 8th Nov 2014

Journal: Med Image Anal

Abstract (Expand)

Modes of sexual reproduction in eukaryotic organisms are extremely diverse. The human fungal pathogen Candida albicans undergoes a phenotypic switch from the white to the opaque phase in order to become ...

Author: Tao L.,Cao C.,Liang W.,Guan G.,Zhang Q.,Nobile C. J.,Huang G.

Date Published: 21st Oct 2014

Journal: PLoS Genet

Abstract (Expand)

Fungal pathogens must assimilate local nutrients to establish an infection in their mammalian host. We focus on carbon, nitrogen, and micronutrient assimilation mechanisms, discussing how these influence ...

Authors: Bernhard Hube, Ene I. V.,Brunke S.,Brown A. J.

Date Published: 4th Sep 2014

Journal: Cold Spring Harb Perspect Med

Abstract (Expand)

Candida albicans demonstrates three main growth morphologies: yeast, pseudohyphal and true hyphal forms. Cell separation is distinct in these morphological forms and the process of separation is closely ...

Author: Milne S. W.,Cheetham J.,Lloyd D.,Shaw S.,Moore K.,Paszkiewicz K. H.,Aves S. J.,Bates S.

Date Published: 29th Jun 2014

Journal: Fungal Genet Biol

Abstract (Expand)

OBJECTIVES: Candida albicans is an important fungal pathogen that can cause life-threatening disseminated infections. To determine the efficacy of therapy in murine models, a determination of renal ...

Authors: Ilse Jacobsen, Oliver Kurzai, Bernhard Hube, Matthias Brock, Luttich A.

Date Published: 20th Jun 2014

Journal: J Antimicrob Chemother

Abstract (Expand)

Little is known regarding the role of NK cells during primary and secondary disseminated Candida albicans infection. We assessed the role of NK cells for host defense against candidiasis in immunocompetent, ...

Authors: Ilse Jacobsen, Bernhard Hube, Oliver Kurzai, Quintin J.,Voigt J.,van der Voort R.,Verschueren I.,Giamarellos-Bourboulis E. J.,van der Meer J. W.,Joosten L. A.,Netea M. G.

Date Published: 27th May 2014

Journal: Eur J Immunol

Abstract (Expand)

Oral candidiasis remains one of the most common forms of Candida infections and occurs if the balance between host, Candida and microbiota is disturbed, e.g., by broad spectrum antibiotics or ...

Authors: Bernhard Hube, Ilse Jacobsen, Hebecker B.,Naglik J. R.

Date Published: 7th May 2014

Journal: Expert Rev Anti Infect Ther

Abstract (Expand)

Nitrogen is one of the key nutrients for microbial growth. During infection, pathogenic fungi like C. albicans need to acquire nitrogen from a broad range of different and changing sources inside the ...

Authors: Jörg Linde, Matthias Brock, Reinhard Guthke, Bernhard Hube, Ramachandra S.,Brunke S.

Date Published: 20th Mar 2014

Journal: PLoS One

Abstract (Expand)

Human fungal pathogens are distributed throughout their kingdom, suggesting that pathogenic potential evolved independently. Candida albicans is the most virulent member of the CUG clade of yeasts and ...

Authors: Ilse Jacobsen, Bernhard Hube, Wilson D.,Mayer F. L.,Miramon P.,Citiulo F.,Slesiona S.

Date Published: 7th Mar 2014

Journal: Eukaryot Cell

Abstract (Expand)

Candida albicans bloodstream infection is increasingly frequent and can result in disseminated candidiasis associated with high mortality rates. To analyze the innate immune response against C. albicans, ...

Authors: Kerstin Hünniger, Marc Thilo Figge, Oliver Kurzai, Lehnert T.,Bieber K.,Martin R.

Date Published: 20th Feb 2014

Journal: PLoS Comput Biol

Abstract (Expand)

Candida albicans is the most common opportunistic fungal pathogen of the human mucosal flora, frequently causing infections. The fungus is responsible for invasive infections in immunocompromised ...

Authors: Bernhard Hube, Mech F.,Wilson D.,Lehnert T.,Thilo Figge M.

Date Published: 20th Nov 2013

Journal: Cytometry A

Abstract (Expand)

BACKGROUND: Natural killer (NK) cells are innate lymphocytes with potent cytotoxic activity. Whereas activity of NK cells has been demonstrated against the fungal pathogens Aspergillus fumigatus and ...

Authors: Kerstin Hünniger, Ilse Jacobsen, Bernhard Hube, Jürgen Löffler, Oliver Kurzai, Voigt J.,Bouzani M.,Barz D.

Date Published: 25th Oct 2013

Journal: J Infect Dis

Abstract (Expand)

The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the ...

Authors: Bernhard Hube, Wilson D.,Hebecker B.,Moyes D. L.,Miramon P.,Jablonowski N.,Wisgott S.,Allert S.,Naglik J. R.

Date Published: 29th Jul 2013

Journal: Antimicrob Agents Chemother

Abstract:

Not specified

Authors: Ilse Jacobsen, Barbara Schaarschmidt, Bernhard Hube, Michael Bauer, Otto G. P.,Ludewig K.

Date Published: 12th Jun 2013

Journal: Crit Care

Abstract (Expand)

BACKGROUND: Although Candida albicans and Candida dubliniensis are most closely related, both species behave significantly different with respect to morphogenesis and virulence. In order to gain further ...

Author: Grumaz C.,Lorenz S.,Stevens P.,Lindemann E.,Schock U.,Retey J.,Rupp S.,Sohn K.

Date Published: 4th Apr 2013

Journal: BMC Genomics

Abstract (Expand)

Systemic infections of humans with the fungal pathogen Candida albicans are associated with a high mortality rate. Currently, efficient treatment of these infections is hampered by the relatively low ...

Authors: Bernhard Hube, Mayer F. L.,Wilson D.

Date Published: 22nd Mar 2013

Journal: PLoS One

Abstract (Expand)

Although morphological plasticity is a central virulence trait of Candida albicans, the number of filament-associated genes and the interplay of mechanisms regulating their expression remain unknown. ...

Authors: Daniela Albrecht-Eckardt, Bernhard Hube, Kerstin Hünniger, Oliver Kurzai, Martin R.,Brunke S.

Date Published: 14th Mar 2013

Journal: PLoS One

Abstract (Expand)

The amino acid cysteine has long been known to be toxic at elevated levels for bacteria, fungi, and humans. However, mechanisms of cysteine tolerance in microbes remain largely obscure. Here we show ...

Authors: Ilse Jacobsen, Bernhard Hube, Hennicke F.,Grumbt M.,Lermann U.,Ueberschaar N.,Palige K.,Bottcher B.,Staib C.,Morschhauser J.,Monod M.,Hertweck C.,Staib P.

Date Published: 15th Feb 2013

Journal: Eukaryot Cell

Abstract (Expand)

Despite their classical role as transcriptional repressors, several histone deacetylases, including the baker's yeast Set3/Hos2 complex (Set3C), facilitate gene expression. In the dimorphic human ...

Author: Hnisz D.,Bardet A. F.,Nobile C. J.,Petryshyn A.,Glaser W.,Schock U.,Stark A.,Kuchler K.

Date Published: 14th Dec 2012

Journal: PLoS Genet

Abstract (Expand)

The ability to adapt to diverse micro-environmental challenges encountered within a host is of pivotal importance to the opportunistic fungal pathogen Candida albicans. We have quantified C. albicans ...

Authors: Jörg Linde, Bernhard Hube, Reinhard Guthke, Tierney L.,Muller S.,Brunke S.,Molina J. C.,Schock U.,Kuchler K.

Date Published: 12th Mar 2012

Journal: Front Microbiol

Abstract (Expand)

BACKGROUND: In System Biology, iterations of wet-lab experiments followed by modelling approaches and model-inspired experiments describe a cyclic workflow. This approach is especially useful for the ...

Authors: Jörg Linde, Axel Brakhage, Reinhard Guthke, Hortschansky P.,Fazius E.,Haas H.

Date Published: 19th Jan 2012

Journal: BMC Syst Biol

Abstract (Expand)

Candida albicans is an important human opportunistic fungal pathogen which is frequently found as part of the normal human microbiota. It is well accepted that the fungus interacts with other components ...

Authors: None

Date Published: No date defined

Journal: Cellular Microbiology

Abstract (Expand)

The identification of novel transcription factors associated with antifungal response may allow the discovery of fungus-specific targets for new therapeutic strategies. A collection of 241 Candida ...

Author: Vandeputte P.,Pradervand S.,Ischer F.,Coste A. T.,Ferrari S.,Harshman K.,Sanglard D.

Date Published: No date defined

Journal: Eukaryot Cell

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