Models

This model is a variant of the previously developed SBM of whole-blood infection assay. While in the previous model a spontaneous immune evasion mechanism (A) was implemented in this model immune evasion was caused by PMN molecule secretion (B).

The state-based model (SBM) allow to simulate the interplay between innate immune cells, such as monocytes and PMN, and Candida albicans and to quantify immune reaction rates like phagocytosis and killing rates. It is implemented in C++.

DynaCoSys models the complement system by using a combination of Ordinary and Partial Differential Equations.

In this model we condider a B cell and its surrounding area and simulate movement and binding of receptors and ligands. The receptors can either be membrane bound (B cell receptors) or soluble (antibodies). Furthermore, receptors can either have a simple spherical shape or a more realistic Y-shape. This allows comparison of the binding dynamics with regard to the dimensionality of motion (membrane-bound vs. soluble), morphology and the binding valency.