Models

Adaptation of the previously developed virtual infection model of Aspergillus fumigatus in a human alveolus. This model comprises a hybrid agent-based model of a single murine alveolus. The alveolus is represented in a realistic to-scale representation and contains the cell types of alveolar epithelial cells (AEC) of type 1 and 2 as well as the pores of Kohn (PoK). Furthermore, in this model, depending on the infection dose multiple A. fumigatus conidium are inserted into the alveolus and the ...

This model comprises a hybrid agent-based model of a single human alveolus. The alveolus is represented in a realistic to-scale representation and contains the cell types of alveolar epithelial cells (AEC) of type 1 and 2 as well as the pores of Kohn (PoK). A single A. fumigatus conidium in inserted into the alveolus and the AEC, where the conidium is located secretes chemokines. Chemokine secretion is modelled using the partial differential equation of the diffusion equation and numerically ...

This is the image analysis algorithm used in Cseresnyes, Kraibooj and Figge, Hessian-based quantitative image analysis of host-pathogen confrontation assays Cytometry A. 2018 Mar;93(3):346-356. doi: 10.1002/cyto.a.23201. Code is being maintained at https://github.com/applied-systems-biology/ACAQ3.

Read.me

This package contains code that implements the Hessian-based macrophage segmentation algorithm. In addition, the ...