This model is a variant of the previously developed SBM of whole-blood infection assay. While in the previous model a spontaneous immune evasion mechanism (A) was implemented in this model immune evasion was caused by PMN molecule secretion (B).
Creators: Teresa Lehnert, Maria T. E. Prauße
Contributor: Sandra Timme
Model type: Not specified
Model format: Not specified
Environment: Not specified
Organism: Candida albicans
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
The state-based model (SBM) allow to simulate the interplay between innate immune cells, such as monocytes and PMN, and Candida albicans and to quantify immune reaction rates like phagocytosis and killing rates. It is implemented in C++.
Creator: Teresa Lehnert
Contributor: Sandra Timme
Model type: Not specified
Model format: Not specified
Environment: Not specified
Organism: Candida albicans
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
Abstract (Expand)
Authors: J. Pollmacher, Sandra Timme, Stefan Schuster, Axel Brakhage, Peter Zipfel, Marc Thilo Figge
Date Published: 13th Jun 2016
Journal: Sci Rep
PubMed ID: 27291424
Citation: Sci Rep. 2016 Jun 13;6:27807. doi: 10.1038/srep27807.