Host-pathogen interactions between the human innate immune system and Candida albicans-understanding and modeling defense and evasion strategies

Abstract:

The diploid, polymorphic yeast Candida albicans is one of the most important human pathogenic fungi. C. albicans can grow, proliferate and coexist as a commensal on or within the human host for a long time. However, alterations in the host environment can render C. albicans virulent. In this review, we describe the immunological cross-talk between C. albicans and the human innate immune system. We give an overview in form of pairs of human defense strategies including immunological mechanisms as well as general stressors such as nutrient limitation, pH, fever etc. and the corresponding fungal response and evasion mechanisms. Furthermore, Computational Systems Biology approaches to model and investigate these complex interactions are highlighted with a special focus on game-theoretical methods and agent-based models. An outlook on interesting questions to be tackled by Systems Biology regarding entangled defense and evasion mechanisms is given.

SEEK ID: https://funginet.hki-jena.de/publications/25

PubMed ID: 26175718

Projects: FungiNet B - Bioinformatics projects, FungiNet C - Candida projects

Publication type: Not specified

Journal: Front Microbiol

Citation:

Date Published: 30th Jun 2015

Registered Mode: Not specified

Authors: , S. Germerodt, , , ,

help Submitter
Activity

Views: 2362

Created: 8th Mar 2016 at 16:03

Last updated: 17th Jan 2024 at 10:24

help Tags

This item has not yet been tagged.

help Attributions

None

Powered by
(v.1.13.4)
Copyright © 2008 - 2023 The University of Manchester and HITS gGmbH