Lipid metabolic signatures deviate in sepsis survivors compared to non-survivors.
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BiBTeXSepsis remains a major cause of death despite advances in medical care. Metabolic deregulation is an important component of the survival process. Metabolomic analysis allows profiling of critical metabolic functions with the potential to classify patient outcome. Our prospective longitudinal characterization of 33 septic and non-septic critically ill patients showed that deviations, independent of direction, in plasma levels of lipid metabolites were associated with sepsis mortality. We identified a coupling of metabolic signatures between liver and plasma of a rat sepsis model that allowed us to apply a human kinetic model of mitochondrial beta-oxidation to reveal differing enzyme concentrations for medium/short-chain hydroxyacyl-CoA dehydrogenase (elevated in survivors) and crotonase (elevated in non-survivors). These data suggest a need to monitor cellular energy metabolism beyond the available biomarkers. A loss of metabolic adaptation appears to be reflected by an inability to maintain cellular (fatty acid) metabolism within a "corridor of safety".
SEEK ID: https://funginet.hki-jena.de/publications/108
PubMed ID: 33304464
Publication type: Not specified
Journal: Comput Struct Biotechnol J
Citation: Comput Struct Biotechnol J. 2020 Nov 21;18:3678-3691. doi: 10.1016/j.csbj.2020.11.009. eCollection 2020.
Date Published: 11th Dec 2020
Registered Mode: Not specified
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Created: 11th Feb 2021 at 08:55
Last updated: 17th Jan 2024 at 10:24
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Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)
https://orcid.org/0000-0001-6106-724X
Projects: A1, A2, A3, A4 (E), A5, A6, B1, B2, B4, B5, C2, C1, C3, C4 (E), C5, C6 (E), FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, FungiNet total, INF, Z1, Z2, B3 (E), A7, A8, C7
Institutions: Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)
https://orcid.org/0000-0003-3862-6546
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Projects: FungiNet total, FungiNet A - Aspergillus projects, FungiNet B - Bioinformatics projects, FungiNet C - Candida projects, INF, A1, A2, A3, A4 (E), A5, B1, B2, B3 (E), B4, C1, C2, C3, C4 (E), C5, C6 (E), Z2, Z1, B5, A6, A7, A8, C7
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