Probing the unknowns in cytokinin-mediated immune defense in Arabidopsis with systems biology approaches


Plant hormones involving salicylic acid (SA), jasmonic acid (JA), ethylene (Et), and auxin, gibberellins, and abscisic acid (ABA) are known to regulate host immune responses. However, plant hormone cytokinin has the potential to modulate defense signaling including SA and JA. It promotes plant pathogen and herbivore resistance; underlying mechanisms are still unknown. Using systems biology approaches, we unravel hub points of immune interaction mediated by cytokinin signaling in Arabidopsis. High-confidence Arabidopsis protein-protein interactions (PPI) are coupled to changes in cytokinin-mediated gene expression. Nodes of the cellular interactome that are enriched in immune functions also reconstitute sub-networks. Topological analyses and their specific immunological relevance lead to the identification of functional hubs in cellular interactome. We discuss our identified immune hubs in light of an emerging model of cytokinin-mediated immune defense against pathogen infection in plants.


PubMed ID: 24558299

Projects: FungiNet B - Bioinformatics projects

Journal: Bioinform Biol Insights


Date Published: 13th Feb 2014

Authors: M. Naseem, M. Kunz, Thomas Dandekar

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Created: 8th Mar 2016 at 16:02

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