Interference of Aspergillus fumigatus with the immune response


Aspergillus fumigatus is a saprotrophic filamentous fungus and also the most prevalent airborne fungal pathogen of humans. Depending on the host's immune status, the variety of diseases caused by A. fumigatus ranges from allergies in immunocompetent hosts to life-threatening invasive infections in patients with impaired immunity. In contrast to the majority of other Aspergillus species, which are in most cases nonpathogenic, A. fumigatus features an armory of virulence determinants to establish an infection. For example, A. fumigatus is able to evade the human complement system by binding or degrading complement regulators. Furthermore, the fungus interferes with lung epithelial cells, alveolar macrophages, and neutrophil granulocytes to prevent killing by these immune cells. This chapter summarizes the different strategies of A. fumigatus to manipulate the immune response. We also discuss the potential impact of recent advances in immunoproteomics to improve diagnosis and therapy of an A. fumigatus infection.


PubMed ID: 25404120

Projects: FungiNet A - Aspergillus projects

Journal: Semin Immunopathol


Date Published: 18th Nov 2014

Authors: T. Heinekamp, H. Schmidt, K. Lapp, V. Pahtz, Iordana Shopova, N. Koster-Eiserfunke, T. Kruger, O. Kniemeyer, Axel Brakhage

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Created: 8th Mar 2016 at 08:59

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