White cells facilitate opposite- and same-sex mating of opaque cells in Candida albicans.

Abstract:

Modes of sexual reproduction in eukaryotic organisms are extremely diverse. The human fungal pathogen Candida albicans undergoes a phenotypic switch from the white to the opaque phase in order to become mating-competent. In this study, we report that functionally- and morphologically-differentiated white and opaque cells show a coordinated behavior during mating. Although white cells are mating-incompetent, they can produce sexual pheromones when treated with pheromones of the opposite mating type or by physically interacting with opaque cells of the opposite mating type. In a co-culture system, pheromones released by white cells induce opaque cells to form mating projections, and facilitate both opposite- and same-sex mating of opaque cells. Deletion of genes encoding the pheromone precursor proteins and inactivation of the pheromone response signaling pathway (Ste2-MAPK-Cph1) impair the promoting role of white cells (MTLa) in the sexual mating of opaque cells. White and opaque cells communicate via a paracrine pheromone signaling system, creating an environment conducive to sexual mating. This coordination between the two different cell types may be a trade-off strategy between sexual and asexual lifestyles in C. albicans.

SEEK ID: https://funginet.hki-jena.de/publications/91

PubMed ID: 25329547

Projects: FungiNet C - Candida projects

Journal: PLoS Genet

Citation: PLoS Genet. 2014 Oct 16;10(10):e1004737. doi: 10.1371/journal.pgen.1004737. eCollection 2014 Oct.

Date Published: 21st Oct 2014

Authors: L. Tao, C. Cao, W. Liang, G. Guan, Q. Zhang, C. J. Nobile, G. Huang

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Created: 15th Nov 2017 at 12:11

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