Candidalysin is a fungal peptide toxin critical for mucosal infection

Abstract:

Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate or modulate host immune responses. Such toxins have not been identified previously in human pathogenic fungi. Here we identify the first, to our knowledge, fungal cytolytic peptide toxin in the opportunistic pathogen Candida albicans. This secreted toxin directly damages epithelial membranes, triggers a danger response signalling pathway and activates epithelial immunity. Membrane permeabilization is enhanced by a positive charge at the carboxy terminus of the peptide, which triggers an inward current concomitant with calcium influx. C. albicans strains lacking this toxin do not activate or damage epithelial cells and are avirulent in animal models of mucosal infection. We propose the name 'Candidalysin' for this cytolytic peptide toxin; a newly identified, critical molecular determinant of epithelial damage and host recognition of the clinically important fungus, C. albicans.

SEEK ID: https://funginet.hki-jena.de/publications/61

PubMed ID: 27027296

Projects: FungiNet C - Candida projects

Publication type: Not specified

Journal: Nature

Citation:

Date Published: 30th Mar 2016

Registered Mode: Not specified

Authors: D. L. Moyes, D. Wilson, J. P. Richardson, S. Mogavero, S. X. Tang, J. Wernecke, S. Hofs, R. L. Gratacap, J. Robbins, M. Runglall, C. Murciano, M. Blagojevic, S. Thavaraj, , B. Hebecker, , G. Vizcay, S. I. Iancu, N. Kichik, A. Hader, , T. Luo, T. Kruger, O. Kniemeyer, E. Cota, O. Bader, R. T. Wheeler, T. Gutsmann, , J. R. Naglik

help Submitter
Activity

Views: 2310

Created: 29th Apr 2016 at 11:36

Last updated: 17th Jan 2024 at 10:24

help Tags

This item has not yet been tagged.

help Attributions

None

Powered by
(v.1.13.4)
Copyright © 2008 - 2023 The University of Manchester and HITS gGmbH