Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection

Abstract:

The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a "danger response" transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection.

SEEK ID: https://funginet.hki-jena.de/publications/49

PubMed ID: 23896471

Projects: FungiNet C - Candida projects

Publication type: Not specified

Journal: Antimicrob Agents Chemother

Citation:

Date Published: 29th Jul 2013

Registered Mode: Not specified

Authors: D. Wilson, B. Hebecker, D. L. Moyes, P. Miramon, N. Jablonowski, S. Wisgott, S. Allert, J. R. Naglik,

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Created: 14th Mar 2016 at 12:57

Last updated: 17th Jan 2024 at 10:24

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