Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection


The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a "danger response" transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection.


PubMed ID: 23896471

Projects: FungiNet C - Candida projects

Journal: Antimicrob Agents Chemother


Date Published: 29th Jul 2013

Authors: D. Wilson, B. Hebecker, D. L. Moyes, P. Miramon, N. Jablonowski, S. Wisgott, S. Allert, J. R. Naglik, Bernhard Hube

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Views: 1665

Created: 14th Mar 2016 at 12:57

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