Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection

Abstract:

The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a "danger response" transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection.

SEEK ID: https://funginet.hki-jena.de/publications/49

PubMed ID: 23896471

Projects: FungiNet C - Candida projects

Journal: Antimicrob Agents Chemother

Citation:

Date Published: 29th Jul 2013

Authors: D. Wilson, B. Hebecker, D. L. Moyes, P. Miramon, N. Jablonowski, S. Wisgott, S. Allert, J. R. Naglik, Bernhard Hube

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