The Definition of Open Reading Frame Revisited.


The term open reading frame (ORF) is of central importance to gene finding. Surprisingly, at least three definitions are in use. We discuss several molecular biological and bioinformatics aspects, and we recommend using the definition in which an ORF is bounded by stop codons.


PubMed ID: 29366605

Projects: B1

Publication type: Not specified

Journal: Trends Genet

Citation: Trends Genet. 2018 Mar;34(3):167-170. doi: 10.1016/j.tig.2017.12.009. Epub 2018 Jan 30.

Date Published: 26th Jan 2018

Registered Mode: Not specified

Authors: P. Sieber, M. Platzer, S. Schuster

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Views: 1435

Created: 20th Feb 2021 at 15:02

Last updated: 17th Jan 2024 at 10:24

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