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27 Projects found

Gene-engineered CAR T-cells and macrophages to treat Aspergillus fumigatus infection

Integrated database for experimental data

Within the Collaborative Research Center / Transregio 124 “Pathogenic fungi and their human host: Networks of Interaction – FungiNet”, the INF project is responsible to analyse and share OMICS data. Databases help to foster the collaboration within FungiNet as an important point of the Collaborative Research Center. Therefore, we set-up two databases:

a) SEEK is a web-based platform to find, share and exchange unstructured data and knowledge, such as ...

Role and targeting of bioactive lipid mediators in Aspergillus fumigatus innate immune cell interactions

Mechanisms of adhesion and modulation of human immune cells by Candida albicans

Role of secreted Candida albicans proteins in immune evasion and pathogenicity

Modelling interactions between the host and fungal pathogens by combining metabolic pathway analysis and evolutionary game theory

Image data analysis and agent-based modelling of the spatio-temporal interaction between immune cells and human-pathogenic fungi

Intrinsic modulation of neutrophil antifungal activity against Candida albicans

Interaction of Aspergillus fumigatus with human natural killer cells, dendritic cells and human alveolar epithelia

In vivo analysis of temporal and spatial disease progression and immune cell recruitment during invasive Aspergillus fumigatus and Candida albicans infections

Gastrointestinal colonisation and mechanisms of translocation of Candida albicans through gut mucosa

Interaction networks of signalling molecules and pathways between the pathogenic fungi Aspergillus fumigatus and Candida albicans and their human host

Predictive modelling of host-fungal pathogen interactions by reconstruction of gene regulatory networks

In project Z2 a sophisticated proteome analysis platform will be provided based on 2D-gel electrophoresis (2D-GE), MALDI-TOF and LC-MS/MS techniques to specific A and Cprojects.

Immunomodulatory functions of ITAM- and ITIM-coupled receptors (C-type lectins/CTLs and carcinoembryonic antigen-related cell adhesion molecules/CEACAMs) for C. albicans -induced immune responses

Impact of regulatory T cells on human infections caused by Aspergillus fumigatus

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