Abstract (Expand)

Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate or modulate host immune responses. ...

Authors: Toni Förster, Lydia Kasper, Oliver Kurzai, Bernhard Hube, Moyes D. L.,Wilson D.,Richardson J. P.,Mogavero S.,Tang S. X.,Wernecke J.,Hofs S.,Gratacap R. L.,Robbins J.,Runglall M.,Murciano C.,Blagojevic M.,Thavaraj S.,Hebecker B.,Vizcay G.,Iancu S. I.,Kichik N.,Hader A.,Luo T.,Kruger T.,Kniemeyer O.,Cota E.,Bader O.,Wheeler R. T.,Gutsmann T.,Naglik J. R.

Date Published: 30th Mar 2016

Journal: Nature

Abstract (Expand)

Only few Candida species, e.g., Candida albicans, Candida glabrata, Candida dubliniensis, and Candida parapsilosis, are successful colonizers of a human host. Under certain circumstances these species ...

Authors: Bernhard Hube, Ilse Jacobsen, Polke M.

Date Published: 24th Feb 2015

Journal: Adv Appl Microbiol

Abstract (Expand)

Following antifungal treatment, Candida albicans, and other human pathogenic fungi can undergo microevolution, which leads to the emergence of drug resistance. However, the capacity for microevolutionary ...

Authors: Jörg Linde, Ilse Jacobsen, Thomas Wolf, Reinhard Guthke, Oliver Kurzai, Bernhard Hube, Wartenberg A.,Martin R.,Schreiner M.,Horn F.,Jenull S.,Kuchler K.,Forche A.,d'Enfert C.,Brunke S.

Date Published: 4th Dec 2014

Journal: PLoS Genet

Abstract (Expand)

Fungal pathogens must assimilate local nutrients to establish an infection in their mammalian host. We focus on carbon, nitrogen, and micronutrient assimilation mechanisms, discussing how these influence ...

Authors: Bernhard Hube, Ene I. V.,Brunke S.,Brown A. J.

Date Published: 4th Sep 2014

Journal: Cold Spring Harb Perspect Med

Abstract (Expand)

OBJECTIVES: Candida albicans is an important fungal pathogen that can cause life-threatening disseminated infections. To determine the efficacy of therapy in murine models, a determination of renal ...

Authors: Ilse Jacobsen, Oliver Kurzai, Bernhard Hube, Matthias Brock, Luttich A.

Date Published: 20th Jun 2014

Journal: J Antimicrob Chemother

Abstract (Expand)

Little is known regarding the role of NK cells during primary and secondary disseminated Candida albicans infection. We assessed the role of NK cells for host defense against candidiasis in immunocompetent, ...

Authors: Ilse Jacobsen, Bernhard Hube, Oliver Kurzai, Quintin J.,Voigt J.,van der Voort R.,Verschueren I.,Giamarellos-Bourboulis E. J.,van der Meer J. W.,Joosten L. A.,Netea M. G.

Date Published: 27th May 2014

Journal: Eur J Immunol

Abstract (Expand)

Oral candidiasis remains one of the most common forms of Candida infections and occurs if the balance between host, Candida and microbiota is disturbed, e.g., by broad spectrum antibiotics or ...

Authors: Bernhard Hube, Ilse Jacobsen, Hebecker B.,Naglik J. R.

Date Published: 7th May 2014

Journal: Expert Rev Anti Infect Ther

Abstract (Expand)

Nitrogen is one of the key nutrients for microbial growth. During infection, pathogenic fungi like C. albicans need to acquire nitrogen from a broad range of different and changing sources inside the ...

Authors: Jörg Linde, Matthias Brock, Reinhard Guthke, Bernhard Hube, Ramachandra S.,Brunke S.

Date Published: 20th Mar 2014

Journal: PLoS One

Abstract (Expand)

Human fungal pathogens are distributed throughout their kingdom, suggesting that pathogenic potential evolved independently. Candida albicans is the most virulent member of the CUG clade of yeasts and ...

Authors: Ilse Jacobsen, Bernhard Hube, Wilson D.,Mayer F. L.,Miramon P.,Citiulo F.,Slesiona S.

Date Published: 7th Mar 2014

Journal: Eukaryot Cell

Abstract (Expand)

Candida albicans is the most common opportunistic fungal pathogen of the human mucosal flora, frequently causing infections. The fungus is responsible for invasive infections in immunocompromised ...

Authors: Bernhard Hube, Mech F.,Wilson D.,Lehnert T.,Thilo Figge M.

Date Published: 20th Nov 2013

Journal: Cytometry A

Abstract (Expand)

BACKGROUND: Natural killer (NK) cells are innate lymphocytes with potent cytotoxic activity. Whereas activity of NK cells has been demonstrated against the fungal pathogens Aspergillus fumigatus and ...

Authors: Kerstin Hünniger, Ilse Jacobsen, Bernhard Hube, Jürgen Löffler, Oliver Kurzai, Voigt J.,Bouzani M.,Barz D.

Date Published: 25th Oct 2013

Journal: J Infect Dis

Abstract (Expand)

The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the ...

Authors: Bernhard Hube, Wilson D.,Hebecker B.,Moyes D. L.,Miramon P.,Jablonowski N.,Wisgott S.,Allert S.,Naglik J. R.

Date Published: 29th Jul 2013

Journal: Antimicrob Agents Chemother


Not specified

Authors: Ilse Jacobsen, Barbara Schaarschmidt, Bernhard Hube, Michael Bauer, Otto G. P.,Ludewig K.

Date Published: 12th Jun 2013

Journal: Crit Care

Abstract (Expand)

Systemic infections of humans with the fungal pathogen Candida albicans are associated with a high mortality rate. Currently, efficient treatment of these infections is hampered by the relatively low ...

Authors: Bernhard Hube, Mayer F. L.,Wilson D.

Date Published: 22nd Mar 2013

Journal: PLoS One

Abstract (Expand)

Although morphological plasticity is a central virulence trait of Candida albicans, the number of filament-associated genes and the interplay of mechanisms regulating their expression remain unknown. ...

Authors: Daniela Albrecht-Eckardt, Bernhard Hube, Kerstin Hünniger, Oliver Kurzai, Martin R.,Brunke S.

Date Published: 14th Mar 2013

Journal: PLoS One

Abstract (Expand)

The amino acid cysteine has long been known to be toxic at elevated levels for bacteria, fungi, and humans. However, mechanisms of cysteine tolerance in microbes remain largely obscure. Here we show ...

Authors: Ilse Jacobsen, Bernhard Hube, Hennicke F.,Grumbt M.,Lermann U.,Ueberschaar N.,Palige K.,Bottcher B.,Staib C.,Morschhauser J.,Monod M.,Hertweck C.,Staib P.

Date Published: 15th Feb 2013

Journal: Eukaryot Cell

Abstract (Expand)

The ability to adapt to diverse micro-environmental challenges encountered within a host is of pivotal importance to the opportunistic fungal pathogen Candida albicans. We have quantified C. albicans ...

Authors: Jörg Linde, Bernhard Hube, Reinhard Guthke, Tierney L.,Muller S.,Brunke S.,Molina J. C.,Schock U.,Kuchler K.

Date Published: 12th Mar 2012

Journal: Front Microbiol

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