Publications

Abstract (Expand)

Aspergillus fumigatus is the predominant airborne pathogenic fungus causing invasive aspergillosis in immunocompromised patients. During infection A. fumigatus has to adapt to oxygen-limiting conditions ...

Authors: Ilse Jacobsen, Ekaterina Shelest, Axel Brakhage, Olaf Kniemeyer, Kroll K.,Shekhova E.,Mattern D. J.,Thywissen A.,Strassburger M.,Heinekamp T.

Date Published: 19th Mar 2016

Journal: Mol Microbiol

Abstract (Expand)

Aspergillus fumigatus is the species that most commonly causes the opportunistic infection invasive aspergillosis (IA) in patients being treated for hematological malignancies. Little is known about ...

Authors: Jürgen Löffler, Hermann Einsele, Reinhard Guthke, Axel Brakhage, Olaf Kniemeyer, Teutschbein J.,Simon S.,Lother J.,Springer J.,Hortschansky P.,Morton C. O.,Conneally E.,Rogers T. R.

Date Published: 15th Mar 2016

Journal: J Proteome Res

Abstract (Expand)

Here, we report the draft genome sequence of Aspergillus calidoustus (strain SF006504). The functional annotation of A. calidoustus predicts a relatively large number of secondary metabolite gene ...

Authors: Jörg Linde, Reinhard Guthke, Axel Brakhage, Vito Valiante, Horn F.,Mattern D. J.,Walther G.,Scherlach K.,Martin K.,Petzke L.

Date Published: 12th Mar 2016

Journal: Genome Announc

Abstract (Expand)

Mitogen activated protein kinases (MAPKs) are highly conserved in eukaryotic organisms. In pathogenic fungi, their activities were assigned to different physiological functions including drug adaptation ...

Authors: Reinhard Guthke, Axel Brakhage, Jörg Linde, Altwasser R.,Baldin C.,Weber J.,Kniemeyer O.,Valiante V.

Date Published: 10th Sep 2015

Journal: PLoS One

Abstract (Expand)

The genus Penicillium belongs to the phylum Ascomycota and includes a variety of fungal species important for food and drug production. We report the draft genome sequence of Penicillium brasilianum ...

Authors: Jörg Linde, Reinhard Guthke, Axel Brakhage, Horn F.,Mattern D. J.,Walther G.,Valiante V.

Date Published: 5th Sep 2015

Journal: Genome Announc

Abstract (Expand)

Studying the pathobiology of the fungus Aspergillus fumigatus has gained a lot of attention in recent years. This is due to the fact that this fungus is a human pathogen that can cause severe diseases, ...

Authors: Hanno Schoeler, Axel Brakhage, Marc Thilo Figge, Kraibooj K.,Svensson C. M.

Date Published: 9th Jun 2015

Journal: Front Microbiol

Abstract (Expand)

Fungal infections have increased dramatically in the last 2 decades, and fighting infectious diseases requires innovative approaches such as the combination of two drugs acting on different targets or ...

Authors: Vito Valiante, Olaf Kniemeyer, Axel Brakhage, Monteiro M. C.,Martin J.,Altwasser R.,El Aouad N.,Gonzalez I.,Mellado E.,Palomo S.,de Pedro N.,Perez-Victoria I.,Tormo J. R.,Vicente F.,Reyes F.,Genilloud O.

Date Published: 8th Jun 2015

Journal: Antimicrob Agents Chemother

Abstract (Expand)

The Tor (target of rapamycin) kinase is one of the major regulatory nodes in eukaryotes. Here, we analyzed the Tor kinase in Aspergillus fumigatus, which is the most important airborne fungal pathogen ...

Authors: Axel Brakhage, Baldin C.,Valiante V.,Kruger T.,Schafferer L.,Haas H.,Kniemeyer O.

Date Published: 26th May 2015

Journal: Proteomics

Abstract (Expand)

Verticillium hemipterigenum (anamorph Torrubiella hemipterigena) is an entomopathogenic fungus and produces a broad range of secondary metabolites. Here, we present the draft genome sequence of the ...

Authors: Axel Brakhage, Reinhard Guthke, Jörg Linde, Horn F.,Habel A.,Scharf D. H.,Dworschak J.,Hertweck C.

Date Published: 24th Jan 2015

Journal: Genome Announc

Abstract (Expand)

Aspergillus fumigatus is a saprotrophic filamentous fungus and also the most prevalent airborne fungal pathogen of humans. Depending on the host's immune status, the variety of diseases caused by ...

Authors: Iordana Shopova, Axel Brakhage, Heinekamp T.,Schmidt H.,Lapp K.,Pahtz V.,Koster-Eiserfunke N.,Kruger T.,Kniemeyer O.

Date Published: 18th Nov 2014

Journal: Semin Immunopathol

Abstract (Expand)

Aspergillus fumigatus is a saprophytic mold that can cause life-threatening infections in immunocompromised patients. In the lung, inhaled conidia are confronted with immune effector cells that attack ...

Authors: Axel Brakhage, Lapp K.,Vodisch M.,Kroll K.,Strassburger M.,Kniemeyer O.,Heinekamp T.

Date Published: 11th Sep 2014

Journal: Front Microbiol

Abstract (Expand)

Streptomyces iranensis HM 35 has been shown to exhibit 72.7% DNA-DNA similarity to the important drug rapamycin (sirolimus)-producing Streptomyces rapamycinicus NRRL5491. Here, we report the genome ...

Authors: Reinhard Guthke, Axel Brakhage, Jörg Linde, Horn F.,Schroeckh V.,Netzker T.

Date Published: 19th Jul 2014

Journal: Genome Announc

Abstract (Expand)

The human pathogenic fungus Aspergillus fumigatus normally lives as a soil saprophyte. Its environment includes poorly oxygenated substrates that also occur during tissue invasive growth of the fungus ...

Authors: Jörg Linde, Reinhard Guthke, Olaf Kniemeyer, Axel Brakhage, Hillmann F.,Beckmann N.,Cyrulies M.,Strassburger M.,Heinekamp T.,Haas H.

Date Published: 7th Jul 2014

Journal: Mol Microbiol

Abstract:

Not specified

Authors: Axel Brakhage, Scharf D. H.,Heinekamp T.

Date Published: 30th Jan 2014

Journal: PLoS Pathog

Abstract (Expand)

BACKGROUND: In System Biology, iterations of wet-lab experiments followed by modelling approaches and model-inspired experiments describe a cyclic workflow. This approach is especially useful for the ...

Authors: Jörg Linde, Axel Brakhage, Reinhard Guthke, Hortschansky P.,Fazius E.,Haas H.

Date Published: 19th Jan 2012

Journal: BMC Syst Biol

Abstract (Expand)

Aspergillus fumigatus is a common airborne fungal pathogen of humans and a significant source of mortality in immunocompromised individuals. Here, we provide the most extensive cell wall proteome ...

Authors: Thorsten Heinekamp, Thomas Krüger, Esther Weiß, Kerstin Hünniger, Jürgen Löffler, Oliver Kurzai, Hermann Einsele, Olaf Kniemeyer, Axel Brakhage, Voltersen V.,Blango M. G.,Herrmann S.,Schmidt F.,Strassburger M.,Bacher P.,Lother J.,Liu H.,Hortschansky P.,Scheffold A.,Krappmann S.,Nietzsche S.,Filler S. G.,Reichard U.

Date Published: No date defined

Journal: MBio

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