Publications

Abstract (Expand)

Aspergillus fumigatus is the predominant airborne pathogenic fungus causing invasive aspergillosis in immunocompromised patients. During infection A. fumigatus has to adapt to oxygen-limiting conditions ...

Authors: Ilse Jacobsen, Ekaterina Shelest, Axel Brakhage, Olaf Kniemeyer, Kroll K.,Shekhova E.,Mattern D. J.,Thywissen A.,Strassburger M.,Heinekamp T.

Date Published: 19th Mar 2016

Journal: Mol Microbiol

Abstract (Expand)

Candida albicans and Candida glabrata account for the majority of candidiasis cases worldwide. Although both species are in the same genus, they differ in key virulence attributes. Within this work, ...

Authors: Kerstin Hünniger, Michael Bauer, Ilse Jacobsen, Marc Thilo Figge, Oliver Kurzai, Duggan S.,Essig F.,Mokhtari Z.,Lehnert T.,Brandes S.,Hader A.,Martin R.

Date Published: 5th May 2015

Journal: Cell Microbiol

Abstract (Expand)

Only few Candida species, e.g., Candida albicans, Candida glabrata, Candida dubliniensis, and Candida parapsilosis, are successful colonizers of a human host. Under certain circumstances these species ...

Authors: Bernhard Hube, Ilse Jacobsen, Polke M.

Date Published: 24th Feb 2015

Journal: Adv Appl Microbiol

Abstract (Expand)

Following antifungal treatment, Candida albicans, and other human pathogenic fungi can undergo microevolution, which leads to the emergence of drug resistance. However, the capacity for microevolutionary ...

Authors: Jörg Linde, Ilse Jacobsen, Thomas Wolf, Reinhard Guthke, Oliver Kurzai, Bernhard Hube, Wartenberg A.,Martin R.,Schreiner M.,Horn F.,Jenull S.,Kuchler K.,Forche A.,d'Enfert C.,Brunke S.

Date Published: 4th Dec 2014

Journal: PLoS Genet

Abstract (Expand)

OBJECTIVES: Candida albicans is an important fungal pathogen that can cause life-threatening disseminated infections. To determine the efficacy of therapy in murine models, a determination of renal ...

Authors: Ilse Jacobsen, Oliver Kurzai, Bernhard Hube, Matthias Brock, Luttich A.

Date Published: 20th Jun 2014

Journal: J Antimicrob Chemother

Abstract (Expand)

Little is known regarding the role of NK cells during primary and secondary disseminated Candida albicans infection. We assessed the role of NK cells for host defense against candidiasis in immunocompetent, ...

Authors: Ilse Jacobsen, Bernhard Hube, Oliver Kurzai, Quintin J.,Voigt J.,van der Voort R.,Verschueren I.,Giamarellos-Bourboulis E. J.,van der Meer J. W.,Joosten L. A.,Netea M. G.

Date Published: 27th May 2014

Journal: Eur J Immunol

Abstract (Expand)

Oral candidiasis remains one of the most common forms of Candida infections and occurs if the balance between host, Candida and microbiota is disturbed, e.g., by broad spectrum antibiotics or ...

Authors: Bernhard Hube, Ilse Jacobsen, Hebecker B.,Naglik J. R.

Date Published: 7th May 2014

Journal: Expert Rev Anti Infect Ther

Abstract (Expand)

Human fungal pathogens are distributed throughout their kingdom, suggesting that pathogenic potential evolved independently. Candida albicans is the most virulent member of the CUG clade of yeasts and ...

Authors: Ilse Jacobsen, Bernhard Hube, Wilson D.,Mayer F. L.,Miramon P.,Citiulo F.,Slesiona S.

Date Published: 7th Mar 2014

Journal: Eukaryot Cell

Abstract (Expand)

BACKGROUND: Natural killer (NK) cells are innate lymphocytes with potent cytotoxic activity. Whereas activity of NK cells has been demonstrated against the fungal pathogens Aspergillus fumigatus and ...

Authors: Kerstin Hünniger, Ilse Jacobsen, Bernhard Hube, Jürgen Löffler, Oliver Kurzai, Voigt J.,Bouzani M.,Barz D.

Date Published: 25th Oct 2013

Journal: J Infect Dis

Abstract:

Not specified

Authors: Ilse Jacobsen, Barbara Schaarschmidt, Bernhard Hube, Michael Bauer, Otto G. P.,Ludewig K.

Date Published: 12th Jun 2013

Journal: Crit Care

Abstract (Expand)

The amino acid cysteine has long been known to be toxic at elevated levels for bacteria, fungi, and humans. However, mechanisms of cysteine tolerance in microbes remain largely obscure. Here we show ...

Authors: Ilse Jacobsen, Bernhard Hube, Hennicke F.,Grumbt M.,Lermann U.,Ueberschaar N.,Palige K.,Bottcher B.,Staib C.,Morschhauser J.,Monod M.,Hertweck C.,Staib P.

Date Published: 15th Feb 2013

Journal: Eukaryot Cell

Abstract (Expand)

Candida albicans is a common cause of life-threatening fungal bloodstream infections. In the murine model of systemic candidiasis, the kidney is the primary target organ while the fungal load declines ...

Authors: Michael Bauer, Jörg Linde, Ilse Jacobsen, Hebecker B.,Vlaic S.,Conrad T.,Brunke S.,Kapitan M.,Hube B.

Date Published: No date defined

Journal: Sci Rep

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