Abstract (Expand)

Invasive fungal infections are associated with high mortality rates and are mostly caused by the opportunistic fungi Aspergillus fumigatus and Candida albicans. Immune responses against these fungi are ...

Authors: Andreas Dix, Jörg Linde, Hermann Einsele, Oliver Kurzai, Jürgen Löffler, Czakai K.,Leonhardt I.,Bonin M.

Date Published: 28th Jun 2016

Journal: Sci Rep

Abstract (Expand)

As part of the innate immune system, natural killer (NK) cells are directly involved in the response to fungal infections. Perforin has been identified as the major effector molecule acting against ...

Authors: Dragana Slavkovic Lukic, Jürgen Löffler, Daniela Albrecht-Eckardt, Michael Weber, Stefanie Allert, Oliver Kurzai, Kerstin Hünniger, Voigt J.,Bouzani M.,Martin R.

Date Published: 19th May 2016

Journal: Front Microbiol

Abstract (Expand)

Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate or modulate host immune responses. ...

Authors: Toni Förster, Lydia Kasper, Oliver Kurzai, Bernhard Hube, Moyes D. L.,Wilson D.,Richardson J. P.,Mogavero S.,Tang S. X.,Wernecke J.,Hofs S.,Gratacap R. L.,Robbins J.,Runglall M.,Murciano C.,Blagojevic M.,Thavaraj S.,Hebecker B.,Vizcay G.,Iancu S. I.,Kichik N.,Hader A.,Luo T.,Kruger T.,Kniemeyer O.,Cota E.,Bader O.,Wheeler R. T.,Gutsmann T.,Naglik J. R.

Date Published: 30th Mar 2016

Journal: Nature

Abstract (Expand)

Intestinal epithelial cells (IEC) form a tight barrier to the gut lumen. Paracellular permeability of the intestinal barrier is regulated by tight junction proteins and can be modulated by microorganisms ...

Authors: Sylvie Schulze, Daniela Albrecht-Eckardt, Kerstin Hünniger, Jörg Linde, Reinhard Guthke, Oliver Kurzai, Bohringer M.,Pohlers S.,Piegsa J.,Weber M.,Martin R.

Date Published: 12th Jan 2016

Journal: Cell Microbiol

Abstract (Expand)

Opportunistic fungal pathogens can cause bloodstream infection and severe sepsis upon entering the blood stream of the host. The early immune response in human blood comprises the elimination of pathogens ...

Authors: Sandra Timme, Kerstin Hünniger, Oliver Kurzai, Marc Thilo Figge, Lehnert T.,Pollmacher J.

Date Published: 19th Jun 2015

Journal: Front Microbiol

Abstract (Expand)

Candida albicans and Candida glabrata account for the majority of candidiasis cases worldwide. Although both species are in the same genus, they differ in key virulence attributes. Within this work, ...

Authors: Kerstin Hünniger, Michael Bauer, Ilse Jacobsen, Marc Thilo Figge, Oliver Kurzai, Duggan S.,Essig F.,Mokhtari Z.,Lehnert T.,Brandes S.,Hader A.,Martin R.

Date Published: 5th May 2015

Journal: Cell Microbiol

Abstract (Expand)

Farnesol, produced by the polymorphic fungus Candida albicans, is the first quorum-sensing molecule discovered in eukaryotes. Its main function is control of C. albicans filamentation, a process closely ...

Authors: Kerstin Hünniger, Oliver Kurzai, Leonhardt I.,Spielberg S.,Weber M.,Albrecht-Eckardt D.,Blass M.,Claus R.,Barz D.,Scherlach K.,Hertweck C.,Loffler J.

Date Published: 19th Mar 2015

Journal: MBio

Abstract (Expand)

Candida albicans is a major cause of bloodstream infection which may present as sepsis and septic shock - major causes of morbidity and mortality world-wide. After invasion of the pathogen, innate ...

Authors: Kerstin Hünniger, Oliver Kurzai, Duggan S.,Leonhardt I.

Date Published: 18th Mar 2015

Journal: Virulence

Abstract (Expand)

Sepsis is a clinical syndrome that can be caused by bacteria or fungi. Early knowledge on the nature of the causative agent is a prerequisite for targeted anti-microbial therapy. Besides currently used ...

Authors: Andreas Dix, Kerstin Hünniger, Reinhard Guthke, Oliver Kurzai, Jörg Linde, Weber M.

Date Published: 11th Mar 2015

Journal: Front Microbiol

Abstract (Expand)

Candida glabrata is the second most common pathogenic Candida species and has emerged as a leading cause of nosocomial fungal infections. Its reduced susceptibility to antifungal drugs and its close ...

Authors: Jörg Linde, Patricia Sieber, Konstantin Riege, Manja Marz, Reinhard Guthke, Oliver Kurzai, Duggan S.,Weber M.,Horn F.,Hellwig D.,Martin R.

Date Published: 13th Jan 2015

Journal: Nucleic Acids Res

Abstract (Expand)

Polymorphonuclear neutrophilic granulocytes (PMN) as cellular components of innate immunity play a crucial role in the defense against systemic Candida albicans infection. To analyze stimuli that are ...

Authors: Kerstin Hünniger, Marc Thilo Figge, Oliver Kurzai, Bieber K.,Martin R.,Lehnert T.,Loffler J.,Guo R. F.,Riedemann N. C.

Date Published: 24th Dec 2014

Journal: J Immunol

Abstract (Expand)

Following antifungal treatment, Candida albicans, and other human pathogenic fungi can undergo microevolution, which leads to the emergence of drug resistance. However, the capacity for microevolutionary ...

Authors: Jörg Linde, Ilse Jacobsen, Thomas Wolf, Reinhard Guthke, Oliver Kurzai, Bernhard Hube, Wartenberg A.,Martin R.,Schreiner M.,Horn F.,Jenull S.,Kuchler K.,Forche A.,d'Enfert C.,Brunke S.

Date Published: 4th Dec 2014

Journal: PLoS Genet

Abstract (Expand)

Time-lapse microscopy is an important technique to study the dynamics of various biological processes. The labor-intensive manual analysis of microscopy videos is increasingly replaced by automated ...

Authors: Kerstin Hünniger, Oliver Kurzai, Marc Thilo Figge, Brandes S.,Mokhtari Z.,Essig F.

Date Published: 8th Nov 2014

Journal: Med Image Anal

Abstract (Expand)

OBJECTIVES: Candida albicans is an important fungal pathogen that can cause life-threatening disseminated infections. To determine the efficacy of therapy in murine models, a determination of renal ...

Authors: Ilse Jacobsen, Oliver Kurzai, Bernhard Hube, Matthias Brock, Luttich A.

Date Published: 20th Jun 2014

Journal: J Antimicrob Chemother

Abstract (Expand)

Little is known regarding the role of NK cells during primary and secondary disseminated Candida albicans infection. We assessed the role of NK cells for host defense against candidiasis in immunocompetent, ...

Authors: Ilse Jacobsen, Bernhard Hube, Oliver Kurzai, Quintin J.,Voigt J.,van der Voort R.,Verschueren I.,Giamarellos-Bourboulis E. J.,van der Meer J. W.,Joosten L. A.,Netea M. G.

Date Published: 27th May 2014

Journal: Eur J Immunol

Abstract (Expand)

Candida albicans bloodstream infection is increasingly frequent and can result in disseminated candidiasis associated with high mortality rates. To analyze the innate immune response against C. albicans, ...

Authors: Kerstin Hünniger, Marc Thilo Figge, Oliver Kurzai, Lehnert T.,Bieber K.,Martin R.

Date Published: 20th Feb 2014

Journal: PLoS Comput Biol

Abstract (Expand)

BACKGROUND: Natural killer (NK) cells are innate lymphocytes with potent cytotoxic activity. Whereas activity of NK cells has been demonstrated against the fungal pathogens Aspergillus fumigatus and ...

Authors: Kerstin Hünniger, Ilse Jacobsen, Bernhard Hube, Jürgen Löffler, Oliver Kurzai, Voigt J.,Bouzani M.,Barz D.

Date Published: 25th Oct 2013

Journal: J Infect Dis

Abstract (Expand)

Although morphological plasticity is a central virulence trait of Candida albicans, the number of filament-associated genes and the interplay of mechanisms regulating their expression remain unknown. ...

Authors: Daniela Albrecht-Eckardt, Bernhard Hube, Kerstin Hünniger, Oliver Kurzai, Martin R.,Brunke S.

Date Published: 14th Mar 2013

Journal: PLoS One

Abstract (Expand)

Aspergillus fumigatus is a common airborne fungal pathogen of humans and a significant source of mortality in immunocompromised individuals. Here, we provide the most extensive cell wall proteome ...

Authors: Thorsten Heinekamp, Thomas Krüger, Esther Weiß, Kerstin Hünniger, Jürgen Löffler, Oliver Kurzai, Hermann Einsele, Olaf Kniemeyer, Axel Brakhage, Voltersen V.,Blango M. G.,Herrmann S.,Schmidt F.,Strassburger M.,Bacher P.,Lother J.,Liu H.,Hortschansky P.,Scheffold A.,Krappmann S.,Nietzsche S.,Filler S. G.,Reichard U.

Date Published: No date defined

Journal: MBio

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