Projects
Immunomodulatory functions of ITAM- and ITIM-coupled receptors (C-type lectins/CTLs and carcinoembryonic antigen-related cell adhesion molecules/CEACAMs) for C. albicans -induced immune responses
Modelling interactions between the host and fungal pathogens by combining metabolic pathway analysis and evolutionary game theory
Interaction networks of signalling molecules and pathways between the pathogenic fungi Aspergillus fumigatus and Candida albicans and their human host
Predictive modelling of host-fungal pathogen interactions by reconstruction of gene regulatory networks
Image data analysis and agent-based modelling of the spatio-temporal interaction between immune cells and human-pathogenic fungi
Molecular mycology, fungal/host interactions, pathogenicity mechanisms of Candida albicans
Regulation of Candida albicans virulence traits by protein kinases
Intrinsic modulation of neutrophil antifungal activity against Candida albicans
Mechanisms of adhesion and modulation of human immune cells by Candida albicans
Gastrointestinal colonisation and mechanisms of translocation of Candida albicans through gut mucosa
Role of secreted Candida albicans proteins in immune evasion and pathogenicity
Ionic regulation of Th17-mediated immune responses to Candida infection
Integrated database for experimental data
Within the Collaborative Research Center / Transregio 124 “Pathogenic fungi and their human host: Networks of Interaction – FungiNet”, the INF project is responsible to analyse and share OMICS data. Databases help to foster the collaboration within FungiNet as an important point of the Collaborative Research Center. Therefore, we set-up two databases:
a) SEEK is a web-based platform to find, share and exchange unstructured data and knowledge, such as
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Central Tasks
In project Z2 a sophisticated proteome analysis platform will be provided based on 2D-gel electrophoresis (2D-GE), MALDI-TOF and LC-MS/MS techniques to specific A and Cprojects.
