People

The following bullet points characterise my scientific interests and research:

• Metabolic physiology of fungi during host infection
• Biochemical characterisation of metabolic pathways (enzyme purification and characterisation)
• Development of infection models
• Generation of fungal reporter strains
• In vivo imaging of the infection process
• Secondary metabolites from Aspergillus terreus (gene regulation, product formation, biological activity)

Bioprocess data analysis (data mining) Transcriptomics and proteomics data analysis and modelling Gene Regulatory Network inference (Reverse engineering) Decision making support systems in diagnostics, therapy and biotechnology

I study the analysis of high-throughput transcriptom and genome data.

For transcritom data (RNA-Seq, microarrays), I perform preprocessing and statistics to identify differentially expressed genes, as well as their functional analysis. My main focus is the analysis of transcriptom data from human fungal pathogens in infection related conditions (f.e. nutrient limitation) as well as during the interaction with the host (dual RNA-seq). Experimental data is used to set up mathematical models for ...