Publications

Abstract (Expand)

Mushrooms, such as Schizophyllum commune, have a specific odor. Whether this is linked to mating, prerequisite for mushroom formation, or also found in monokaryotic, unmated strains, was investigated ...

Authors: Olaf Kniemeyer, Jörg Linde, Freihorst D.,Brunsch M.,Wirth S.,Krause K.,Kunert M.,Boland W.,Kothe E.

Date Published: 7th Sep 2016

Journal: Fungal Genet Biol

Abstract (Expand)

Humans are continuously exposed to airborne spores of the saprophytic fungus Aspergillus fumigatus. However, in healthy individuals pulmonary host defense mechanisms efficiently eliminate the fungus. ...

Authors: Natarajaswamy Kalleda, Hermann Einsele, Matthias Brock, Katrin Heinze, Andreas Beilhack, Amich J.,Arslan B.,Poreddy S.,Mattenheimer K.,Mokhtari Z.

Date Published: 13th Jul 2016

Journal: Front Microbiol

Abstract (Expand)

Invasive fungal infections are associated with high mortality rates and are mostly caused by the opportunistic fungi Aspergillus fumigatus and Candida albicans. Immune responses against these fungi are ...

Authors: Andreas Dix, Jörg Linde, Hermann Einsele, Oliver Kurzai, Jürgen Löffler, Czakai K.,Leonhardt I.,Bonin M.

Date Published: 28th Jun 2016

Journal: Sci Rep

Abstract (Expand)

As part of the innate immune system, natural killer (NK) cells are directly involved in the response to fungal infections. Perforin has been identified as the major effector molecule acting against ...

Authors: Dragana Slavkovic Lukic, Jürgen Löffler, Daniela Albrecht-Eckardt, Michael Weber, Stefanie Allert, Oliver Kurzai, Kerstin Hünniger, Voigt J.,Bouzani M.,Martin R.

Date Published: 19th May 2016

Journal: Front Microbiol

Abstract (Expand)

The human restricted pathogen Moraxella catarrhalis is an important causal agent for exacerbations in chronic obstructive lung disease (COPD) in adults. In such patients, increased numbers of granulocytes ...

Authors: Tobias Müller, Tilman Klassert, Hortense Slevogt, Heinrich A.,Heyl K. A.,Klaile E.,Wiessner A.,Fischer K.,Schumann R. R.,Seifert U.,Riesbeck K.,Moter A.,Singer B. B.,Bachmann S.

Date Published: 3rd Apr 2016

Journal: Cell Microbiol

Abstract (Expand)

Invasive aspergillosis (IA) is a devastating opportunistic infection and its treatment constitutes a considerable burden for the health care system. Immunocompromised patients are at an increased risk ...

Authors: Andreas Dix, Reinhard Guthke, Hermann Einsele, Jörg Linde, Jürgen Löffler, Czakai K.,Springer J.,Fliesser M.,Bonin M.,Schmitt A. L.

Date Published: 21st Mar 2016

Journal: Front Microbiol

Abstract (Expand)

Mitogen activated protein kinases (MAPKs) are highly conserved in eukaryotic organisms. In pathogenic fungi, their activities were assigned to different physiological functions including drug adaptation ...

Authors: Reinhard Guthke, Axel Brakhage, Jörg Linde, Altwasser R.,Baldin C.,Weber J.,Kniemeyer O.,Valiante V.

Date Published: 10th Sep 2015

Journal: PLoS One

Abstract (Expand)

The genus Penicillium belongs to the phylum Ascomycota and includes a variety of fungal species important for food and drug production. We report the draft genome sequence of Penicillium brasilianum ...

Authors: Jörg Linde, Reinhard Guthke, Axel Brakhage, Horn F.,Mattern D. J.,Walther G.,Valiante V.

Date Published: 5th Sep 2015

Journal: Genome Announc

Abstract (Expand)

BACKGROUND: Invasive aspergillosis is started after germination of Aspergillus fumigatus conidia that are inhaled by susceptible individuals. Fungal hyphae can grow in the lung through the epithelial ...

Author: Irmer H.,Tarazona S.,Sasse C.,Olbermann P.,Loeffler J.,Krappmann S.,Conesa A.,Braus G. H.

Date Published: 28th Aug 2015

Journal: BMC Genomics

Abstract (Expand)

Studying the pathobiology of the fungus Aspergillus fumigatus has gained a lot of attention in recent years. This is due to the fact that this fungus is a human pathogen that can cause severe diseases, ...

Authors: Hanno Schoeler, Axel Brakhage, Marc Thilo Figge, Kraibooj K.,Svensson C. M.

Date Published: 9th Jun 2015

Journal: Front Microbiol

Abstract (Expand)

Fungal infections have increased dramatically in the last 2 decades, and fighting infectious diseases requires innovative approaches such as the combination of two drugs acting on different targets or ...

Authors: Vito Valiante, Olaf Kniemeyer, Axel Brakhage, Monteiro M. C.,Martin J.,Altwasser R.,El Aouad N.,Gonzalez I.,Mellado E.,Palomo S.,de Pedro N.,Perez-Victoria I.,Tormo J. R.,Vicente F.,Reyes F.,Genilloud O.

Date Published: 8th Jun 2015

Journal: Antimicrob Agents Chemother

Abstract (Expand)

The Tor (target of rapamycin) kinase is one of the major regulatory nodes in eukaryotes. Here, we analyzed the Tor kinase in Aspergillus fumigatus, which is the most important airborne fungal pathogen ...

Authors: Axel Brakhage, Baldin C.,Valiante V.,Kruger T.,Schafferer L.,Haas H.,Kniemeyer O.

Date Published: 26th May 2015

Journal: Proteomics

Abstract (Expand)

Sepsis is a clinical syndrome that can be caused by bacteria or fungi. Early knowledge on the nature of the causative agent is a prerequisite for targeted anti-microbial therapy. Besides currently used ...

Authors: Andreas Dix, Kerstin Hünniger, Reinhard Guthke, Oliver Kurzai, Jörg Linde, Weber M.

Date Published: 11th Mar 2015

Journal: Front Microbiol

Abstract (Expand)

Verticillium hemipterigenum (anamorph Torrubiella hemipterigena) is an entomopathogenic fungus and produces a broad range of secondary metabolites. Here, we present the draft genome sequence of the ...

Authors: Axel Brakhage, Reinhard Guthke, Jörg Linde, Horn F.,Habel A.,Scharf D. H.,Dworschak J.,Hertweck C.

Date Published: 24th Jan 2015

Journal: Genome Announc

Abstract (Expand)

Aspergillus fumigatus is a saprotrophic filamentous fungus and also the most prevalent airborne fungal pathogen of humans. Depending on the host's immune status, the variety of diseases caused by ...

Authors: Iordana Shopova, Axel Brakhage, Heinekamp T.,Schmidt H.,Lapp K.,Pahtz V.,Koster-Eiserfunke N.,Kruger T.,Kniemeyer O.

Date Published: 18th Nov 2014

Journal: Semin Immunopathol

Abstract (Expand)

Aspergillus fumigatus is a saprophytic mold that can cause life-threatening infections in immunocompromised patients. In the lung, inhaled conidia are confronted with immune effector cells that attack ...

Authors: Axel Brakhage, Lapp K.,Vodisch M.,Kroll K.,Strassburger M.,Kniemeyer O.,Heinekamp T.

Date Published: 11th Sep 2014

Journal: Front Microbiol

Abstract (Expand)

Beyond its well-documented role in reproduction, embryogenesis and maintenance of body tissues, vitamin A has attracted considerable attention due to its immunomodulatory effects on both the innate and ...

Authors: Tilman Klassert, Hortense Slevogt, Hanisch A.,Brauer J.,Klaile E.,Heyl K. A.,Mansour M. K.,Tam J. M.,Vyas J. M.

Date Published: 17th Aug 2014

Journal: Med Microbiol Immunol

Abstract (Expand)

Streptomyces iranensis HM 35 has been shown to exhibit 72.7% DNA-DNA similarity to the important drug rapamycin (sirolimus)-producing Streptomyces rapamycinicus NRRL5491. Here, we report the genome ...

Authors: Reinhard Guthke, Axel Brakhage, Jörg Linde, Horn F.,Schroeckh V.,Netzker T.

Date Published: 19th Jul 2014

Journal: Genome Announc

Abstract (Expand)

The human pathogenic fungus Aspergillus fumigatus normally lives as a soil saprophyte. Its environment includes poorly oxygenated substrates that also occur during tissue invasive growth of the fungus ...

Authors: Jörg Linde, Reinhard Guthke, Olaf Kniemeyer, Axel Brakhage, Hillmann F.,Beckmann N.,Cyrulies M.,Strassburger M.,Heinekamp T.,Haas H.

Date Published: 7th Jul 2014

Journal: Mol Microbiol

Abstract (Expand)

Unlike induced Foxp3(+) regulatory T cells (Foxp3(+) iTreg) that have been shown to play an essential role in the development of protective immunity to the ubiquitous mold Aspergillus fumigatus, ...

Authors: Tanja Bedke, Max Topp, Iannitti R. G.,De Luca A.,Giovannini G.,Fallarino F.,Berges C.,Latge J. P.,Einsele H.,Romani L.

Date Published: 13th May 2014

Journal: Immunol Cell Biol

Abstract:

Not specified

Authors: Axel Brakhage, Scharf D. H.,Heinekamp T.

Date Published: 30th Jan 2014

Journal: PLoS Pathog

Abstract (Expand)

BACKGROUND: Natural killer (NK) cells are innate lymphocytes with potent cytotoxic activity. Whereas activity of NK cells has been demonstrated against the fungal pathogens Aspergillus fumigatus and ...

Authors: Kerstin Hünniger, Ilse Jacobsen, Bernhard Hube, Jürgen Löffler, Oliver Kurzai, Voigt J.,Bouzani M.,Barz D.

Date Published: 25th Oct 2013

Journal: J Infect Dis

Abstract (Expand)

Fungi produce a multitude of low-molecular-mass compounds known as secondary metabolites, which have roles in a range of cellular processes such as transcription, development and intercellular ...

Author: Brakhage Axel A

Date Published: 26th Nov 2012

Journal: Nat. Rev. Microbiol.

Abstract:

ABSTRACT:

Author: Müller Sebastian,Baldin Clara,Groth Marco,Guthke Reinhard,Kniemeyer Olaf,Brakhage Axel A,Valiante Vito

Date Published: 2nd Oct 2012

Journal: BMC Genomics

Abstract (Expand)

BACKGROUND: In System Biology, iterations of wet-lab experiments followed by modelling approaches and model-inspired experiments describe a cyclic workflow. This approach is especially useful for the ...

Authors: Jörg Linde, Axel Brakhage, Reinhard Guthke, Hortschansky P.,Fazius E.,Haas H.

Date Published: 19th Jan 2012

Journal: BMC Syst Biol

Abstract (Expand)

Non-invasive imaging techniques in microbial disease models have delivered valuable insights in the intimate pathogen-host interplay during infection. Here we describe evaluation and validation of a ...

Author: Donat Stefanie,Hasenberg Mike,Schäfer Tina,Ohlsen Knut,Gunzer Matthias,Einsele Hermann,Löffler Jürgen,Beilhack Andreas,Krappmann Sven

Date Published: 2012

Journal: Virulence

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