Abstract (Expand)

In systems biology, researchers aim to understand complex biological systems as a whole, which is often achieved by mathematical modelling and the analyses of high-throughput data. In this review, we ...

Authors: Andreas Dix, Reinhard Guthke, Jörg Linde, Vlaic S.

Date Published: 27th Apr 2016

Journal: Clin Microbiol Infect

Abstract (Expand)

In the emerging field of systems biology of fungal infection, one of the central roles belongs to the modeling of gene regulatory networks (GRNs). Utilizing omics-data, GRNs can be predicted by ...

Authors: Reinhard Guthke, Theresia Conrad, Ekaterina Shelest, Jörg Linde, Gerber S.,Vlaic S.,Durmus S.,Cakir T.,Sevilgen F. E.

Date Published: 22nd Apr 2016

Journal: Front Microbiol

Abstract (Expand)

Invasive aspergillosis (IA) is a devastating opportunistic infection and its treatment constitutes a considerable burden for the health care system. Immunocompromised patients are at an increased risk ...

Authors: Andreas Dix, Reinhard Guthke, Hermann Einsele, Jörg Linde, Jürgen Löffler, Czakai K.,Springer J.,Fliesser M.,Bonin M.,Schmitt A. L.

Date Published: 21st Mar 2016

Journal: Front Microbiol

Abstract (Expand)

Recent and rapidly evolving progress on high-throughput measurement techniques and computational performance has led to the emergence of new disciplines, such as systems medicine and translational ...

Authors: Theresia Conrad, Reinhard Guthke, Jörg Linde, Schleicher J.,Gustafsson M.,Cedersund G.

Date Published: 10th Feb 2016

Journal: Brief Funct Genomics


Not specified

Authors: Reinhard Guthke, Durmus S.,Cakir T.

Date Published: 4th Feb 2016

Journal: Front Microbiol

Abstract (Expand)

Fungal infections have increased dramatically in the last 2 decades, and fighting infectious diseases requires innovative approaches such as the combination of two drugs acting on different targets or ...

Authors: Vito Valiante, Olaf Kniemeyer, Axel Brakhage, Monteiro M. C.,Martin J.,Altwasser R.,El Aouad N.,Gonzalez I.,Mellado E.,Palomo S.,de Pedro N.,Perez-Victoria I.,Tormo J. R.,Vicente F.,Reyes F.,Genilloud O.

Date Published: 8th Jun 2015

Journal: Antimicrob Agents Chemother

Abstract (Expand)

Gene regulatory network inference is a systems biology approach which predicts interactions between genes with the help of high-throughput data. In this review, we present current and updated network ...

Authors: Jörg Linde, Sylvie Schulze, Reinhard Guthke, Henkel S. G.

Date Published: 2nd Mar 2015

Journal: EXCLI J

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