In this model we condider a B cell and its surrounding area and simulate movement and binding of receptors and ligands. The receptors can either be membrane bound (B cell receptors) or soluble (antibodies). Furthermore, receptors can either have a simple spherical shape or a more realistic Y-shape. This allows comparison of the binding dynamics with regard to the dimensionality of motion (membrane-bound vs. soluble), morphology and the binding valency.
Creator: Teresa Lehnert
Contributor: Sandra Timme
Model type: Agent based modelling
Model format: Not specified
Environment: Not specified
Organism: Not specified
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
Authors: Teresa Lehnert, Marc Thilo Figge
Date Published: 19th Dec 2017
Journal: Front Immunol
PubMed ID: 29250071
Citation: Front Immunol. 2017 Nov 30;8:1692. doi: 10.3389/fimmu.2017.01692. eCollection 2017.