Investigations
This repository contains the data of the study "Aspergillus fumigatus versus Genus Aspergillus: Conservation, adaptive evolution and specific virulence genes"
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S Bruns, M S, D Albrecht, S S, N Remme, C Hertweck, A A. Brakhage, O K, F-M C. Müller. Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin. Proteomics. 2010 Sep;10(17):3097-107.
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O Kniemeyer, F Lessing, O Scheibner, C Hertweck, A A Brakhage. Optimisation of a 2-D gel electrophoresis protocol for the human-pathogenic fungus Aspergillus fumigatus. Curr Genet. 2006 Mar;49(3):178-89. Epub 2005 Dec 17
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C Baldin, V Valiante, T Krüger, L Schafferer, H Haas, O Kniemeyer, A A Brakhage. Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation.
Proteomics. 2015 Jul;15(13):2230-43. doi: 10.1002/pmic.201400584. Epub 2015 May 26.
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Wartenberg D, Vödisch M, Kniemeyer O, Albrecht-Eckardt D, Scherlach K, Winkler R, Weide M, Brakhage AA. Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans-The role of a putative dehydrin. J Proteomics. 2012 May 23.
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P Hortschansky, M Eisendle, Q Al-Abdallah, A D Schmidt, S Bergmann, M Thön, O Kniemeyer, B Abt, B Seeber, E R Werner, M Kato, A A Brakhage and H Haas. Interaction of HapX with the CCAAT-binding complex-a novel mechanism of gene regulation by iron. EMBO J. 2007 Jul 11;26(13):3157-68. Epub 2007 Jun 14
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R Jain, V Valiante, N Remme, T Docimo, T Heinekamp, C Hertweck, J Gershenzon, H Haas, A A Brakhage. The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Mol Microbiol. 2011 October; 82(1): 39–53.
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M Vödisch, K Scherlach, R Winkler, C Hertweck, H-P Braun, M Roth,H Haas, E R Werner, A A Brakhage,O Kniemeyer. Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. J. Proteome Res., 2011, 10 (5), 2508–2524
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F Lessing,O Kniemeyer, I Wozniok, J Loeffler, O Kurzai, A A Brakhage. The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model. Eukaryot Cell. 2007 Dec;6(12):2290-302. Epub 2007 Oct 5
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Kroll K, Shekhova E, Mattern DJ, Thywissen A, Jacobsen ID, Strassburger M, Heinekamp T, Shelest E, Brakhage AA, Kniemeyer O. The hypoxia-induced dehydrogenase HorA is required for coenzyme Q10 biosynthesis, azole sensitivity and virulence of Aspergillus fumigatus.
Mol Microbiol 2016 Mar 17. doi: 10.1111/mmi.13377
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M Vödisch, D Albrecht, F Leßing, A D Schmidt, R Winkler, R Guthke, A A Brakhage, OKniemeyer. Two-dimensional proteome reference maps for the human-pathogenic filamentous fungus Aspergillus fumigatus. Proteomics. 2009 Mar;9(5):1407-1415. View
J Teutschbein, D Albrecht, M Pötsch, R Guthke, V Aimanianda, C Clavaud, JP Latge, A A Brakhage, O Kniemeyer. Proteome Profiling and Functional Classification of Intracellular Proteins from Conidia of the Human-Pathogenic Mold Aspergillus fumigatus. J Proteome
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Teutschbein J, Simon S, Lother J, Springer J, Hortschansky P, Morton CO, Löffler J, Einsele H, Conneally E, Rogers TR, Guthke R, Brakhage AA, Kniemeyer O. Proteomic profiling of serological responses to Aspergillus fumigatus antigens in patients with invasive aspergillosis. J Proteome Res 2016 Mar 24
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A Gehrke,T Heinekamp, I Jacobsen, A Brakhage. Heptahelical receptors GprC and GprD of Aspergillus fumigatus are essential regulators of colony growth, hyphal morphogenesis and virulence. Appl Environ Microbiol. 2010
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Dirk Wartenberg, Katrin Lapp, Ilse D. Jacobsen, Hans-Martin Dahse, Olaf Kniemeyer, Thorsten Heinekamp, Axel A. Brakhage
Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knoell-Institute (HKI), Jena, Germany. Secretome analysis of Aspergillus fumigatus reveals Asp-hemolysin as a major secreted protein. Int J Med Microbiol. 2011, Nov;301(7):602-11
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This service and research topic deals with the spatially resolved field of proteomics which allows targetet and untargeted host-pathogen interaction studies.
Please get into contact with Franziska Hoffmann and Ferdinand von Eggeling if you are interested in spatial proteomics.
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D Albrecht, R Guthke, A A Brakhage, O Kniemeyer. Integrative analysis of the heat shock response in Aspergillus fumigatus. BMC Genomics. 2010 Jan 15;11:32.
Find corresponding transcriptomic data at ArrayExpress: E-MEXP-332
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